Anti inflammatory drugs

Question 1

NSAIDS

Answer 1

Non-selective COX enzyme inhibitors = aspirin, ibuprofen, naproxen

Selective COX enzyme inhibitors ( coxibs ) - valdecoxib, celecoxib

Question 2

Similarities between cyclooxygenase 1 and 2

Answer 2

• two of the enzymes which are responsible for prostaglandins synthesis
• both COXs can produce prostaglandins that promote inflammation, pain and fever

Question 3

Differences between cyclooxygenase 1 and 2 inhibition

Answer 3

• COX 1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining
  COX 2 = a major player in inflammatory reactions

Question 4

Nonselective NSAIDS CLASSIFICATION

Answer 4

• Salicylates ( salicylic acid derivates ) = aspirin ; diflunisal
• Acetic acid derivatives = diclofenac
• Propionic acid derivatives = Ibuprofen ; naproxen