Anti-Inflammatories, DMARDs Flashcards
is acetaminophen an anti-inflammatory ?
no
max dose acetaminophen daily
4 g daily
caution with giving acetaminophen to…
patients with liver disease, and (lesser) kidney disease
side effects of opiates
drowsiness
constipation
types of neuroactive drugs used for rheumatic pain
antidepressants
anti-epileptics
action of neuroactive drugs in treating pain
moderate activity of neurologic pain pathways, especially useful for neuro pain (fibromyalgia)
action of phospholipase C
membrane –> arachidonic acid
action of COX
arachidonic acid –> prostaglandin H2
action of lipoxygenase
arachidonic acid –> leukotriene A4
high doses of PGE’s do what to pain
directly induce pain
low doses of PGE’s do what to pain
sensitize tissues to respond to other stimuli (bradykinin)
how to PGE’s mediate body temperature
via interaction with the posterior hypothalamus
how do PGE’s relieve menstrual pain
direct relief of smooth muscle contraction
which is the “rheumatologist’s aspirin?”
Aspirin III- antiinflammatory.
COX1, 2, and signal transduction
toxicities of NSAIDs: GI
dyspepsia, gastritis, ulceration, bleeding
