Anti-IL5

Question 1

Mepolizumab (Nucala)

Answer 1

Auto-injector & injection

6-Adults

Adverse Effect: headache, injection site reaction, arthralgias, herpes zoster
infection

Counseling: in clinic or at home injection, add on for asthma treatment with
eosinophilic phenotype

Decreased eosinophils and reduced exacerbations by 40-50%

Question 2

Reslizumab (Cinqair)

Answer 2

Solution

18-Adults

Adverse Effect: injection site reaction, myalgias, increased creatinine
phosphokinase

Counseling: add on for asthma treatment with eosinophilic phenotype

Question 3

Benralizumab (Fasenra)

Answer 3

Auto-injector & syringe

Adults

Adverse Effect: injection site reaction, antibody development, headache,
pharyngitis, fever

Counseling: in clinic or at home injection, add on for asthma treatment with
eosinophilic phenotype

ACTS ON IL-5 RECEPTORS

Inhibits differentiation and maturation of eosinophils in bone marrow