Anti-Fungal Drugs Flashcards
Name four classes of anti-fungal drugs
Polyenes
Azoles
Allylamines
Echinocandins
What is the function of polyenes?
bind to ergosterol in fungal cell wall, giving increased permeability
What are polyenes active against?
- yeast
- filamentous fungi
How can polyenes cause toxicity?
bind with other sterols in the body e.g. cholesterol
Name two examples of azoles
Amphotericin B
Nystatin
What is amphotericin B used for?
- IV treatment of serious systemic fungal infection
- can cause renal/hepatic/cardiac toxicity
What is nystatin used for?
- topical treatment of skin infections/candidiasis
What is the function of azoles?
inhibit ergosterol synthesis
Name two divisions of azoles
Imidazoles
Triazoles
(older/newer)
Name three examples of azoles
Fluconazole
Itraconazole
Voriconazole
What is fluconazole used for?
- oral and parenteral treatment of yeast infection
What is the difference between fluconazole and polyenes?
Fluconazole has no action against filamentous fungi species (e.g. aspergillus)
What are the contraindications if fluconazole use?
- no toxicity
- can be resisted by some candida species (e.g. albicans/glabrata)
What is itraconazole used against?
filamentous fungi infection
What is voriconazole used for?
aspergillosis treatment
