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Pharmacology Antibiotics > Anti Fungal > Flashcards

Anti Fungal Flashcards

1
Q

Drugs that target nucleic acid synthesis and cell division

A
  • griseofulvin

- 5-flucytosine

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2
Q

drugs that target the cell membrane by disruption and binding to ergosterol

A
  • amphotericin B

- nystatin

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3
Q

drugs that target the cell membrane by inhibition of ergosterol biosynthesis via C14-alpha demethlyase inhibitors

A
  • azoles
  • -ketoconazole (clotrinazole, miconazole)
  • -fluconazole
  • -itraconazole
  • -voriconazole
  • -posaconazole
  • -efinaconazole
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4
Q

drugs that target the cell membrane by inhibition of ergosterol biosynthesis via squalene epoxidase inhibitors

A

allylamines (benzylamines, terbinafine, naftifine)

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5
Q

drugs that target cell wall synthesis via B-glucan synthase inhibitors

A

caspofungin (anidulafungin, micafungin)

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6
Q

drugs that target protein synthesis via leucyl-tRNA synthetase inhibitor

A

tavaborole

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7
Q

mechanism: mitosis inhibitor that binds to tublin

A

griseofulvin

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8
Q

mechanism: DNA/RNA synthesis inhibitor

A

5-flucytosine

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9
Q

should be taken with a fatty meal

A

griseofulvin

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10
Q

drugs that can be taken by IV only

A
  • amphotericin B

- caspofungin

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11
Q

limited clinical use due to narrow spectrum, resistance, and side effects

A

5-flucytosine

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12
Q

can only be taken orally

A

posaconazole

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13
Q

not metabolized

A

amphoterocin B

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14
Q

active against only fungi and mycoplasma

A

amphoterocin B

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15
Q

good for synergism with triazoles

A

amphoterocin B

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16
Q

best choice for systemic infections (candidosis, histoplasmosis, coccidohicosis)

A

amphoterocin B

17
Q

like amphoterocin B but poorly absorbed with slight metabolism

A

nystatin

18
Q

which are more selective: triazoles or imidazoles?

A

triazoles

19
Q

only imidazole

A

ketoconazole

20
Q

what antifungals are effective against candidosis?

A
  • amphoterocin B
  • ketoconazole
  • fluconazole
  • caspofungin
21
Q

has a broader spectrum than ketoconazole

A

itraconazole

22
Q

must be a low pH in the stomach to be absorbed, doesn’t cross BBB

A

itraconazole

23
Q

what drugs treat invasive aspergillosis

A
  • voriconazole
  • posaconazole
  • caspofungin
24
Q

side effects include visual hallucinations

A

voriconazole

25
Q

drugs used to treat nail and skin infections

A
  • griseofulvin
  • allylamines
  • tavoborole (topical for onchomycosis)

Pharmacology Antibiotics (3 decks)

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