Anti Fungal

Question 1

Drugs that target nucleic acid synthesis and cell division

Answer 1

• griseofulvin

- 5-flucytosine

Question 2

drugs that target the cell membrane by disruption and binding to ergosterol

Answer 2

• amphotericin B

- nystatin

Question 3

drugs that target the cell membrane by inhibition of ergosterol biosynthesis via C14-alpha demethlyase inhibitors

Answer 3

• azoles
• -ketoconazole (clotrinazole, miconazole)
• -fluconazole
• -itraconazole
• -voriconazole
• -posaconazole
• -efinaconazole

Question 4

drugs that target the cell membrane by inhibition of ergosterol biosynthesis via squalene epoxidase inhibitors

Answer 4

allylamines (benzylamines, terbinafine, naftifine)

Question 5

drugs that target cell wall synthesis via B-glucan synthase inhibitors

Answer 5

caspofungin (anidulafungin, micafungin)

Question 6

drugs that target protein synthesis via leucyl-tRNA synthetase inhibitor

Answer 6

tavaborole

Question 7

mechanism: mitosis inhibitor that binds to tublin

Answer 7

griseofulvin

Question 8

mechanism: DNA/RNA synthesis inhibitor

Answer 8

5-flucytosine

Question 9

should be taken with a fatty meal

Answer 9

griseofulvin

Question 10

drugs that can be taken by IV only

Answer 10

• amphotericin B

- caspofungin

Question 11

limited clinical use due to narrow spectrum, resistance, and side effects

Answer 11

5-flucytosine

Question 12

can only be taken orally

Answer 12

posaconazole

Question 13

not metabolized

Answer 13

amphoterocin B

Question 14

active against only fungi and mycoplasma

Answer 14

amphoterocin B

Question 15

good for synergism with triazoles

Answer 15

amphoterocin B

Question 16

best choice for systemic infections (candidosis, histoplasmosis, coccidohicosis)

Answer 16

amphoterocin B

Question 17

like amphoterocin B but poorly absorbed with slight metabolism

Answer 17

nystatin

Question 18

which are more selective: triazoles or imidazoles?

Answer 18

triazoles

Question 19

only imidazole

Answer 19

ketoconazole

Question 20

what antifungals are effective against candidosis?

Answer 20

• amphoterocin B
• ketoconazole
• fluconazole
• caspofungin

Question 21

has a broader spectrum than ketoconazole

Answer 21

itraconazole

Question 22

must be a low pH in the stomach to be absorbed, doesn’t cross BBB

Answer 22

itraconazole

Question 23

what drugs treat invasive aspergillosis

Answer 23

• voriconazole
• posaconazole
• caspofungin

Question 24

side effects include visual hallucinations

Answer 24

voriconazole

Question 25

drugs used to treat nail and skin infections

Answer 25

• griseofulvin
• allylamines
• tavoborole (topical for onchomycosis)