Anti-epileptic Flashcards
What are the phases of tonic-clonic generalized seizure?
1/ Flexion phase
2/Extension phase
3/Tremor phase
4/clinic phase.
Mouth held partly open, upward eye movement, involvement the extremities and being unconscious.
This describe which phase of the TONIC-CLONIC SEIZURE:
Extension
Flexion
Clonic
Tremor
Flexion.
Having tremors or shaking describe which phase of the TONIC-CLONIC SEIZURE: Flexion Extension Clonic Tremor
Tremor.
Extended back and neck and being apneic(cannot breathe),having contraction in the thoracic and abdominal muscle, this describe which phase of TONIC-CLONIC SEIZURE: Flexion Extension Clonic Tremor
Extension.
Having rhythmic jerks describe which phase of TONIC-CLONIC SEIZURES: EXTENSION FLEXION CLONIC TREMOR
Clonic.
Being APNEIC describe which phase of of the TONIC-CLONIC SEIZURE:
Extension
What is the situation the patient being on after the seizure?
Postictal.
Classification of epileptic seizures are?
1/ focal/particular seizure
2/Generalized seizure.
3/status epilepticus.
What is the name of the seizure class that lasts more that 20 minutes and the patient does not regain her/his consciousness between the two episodes of seizure where it’s life-threatening and needed an immediate medical treatment called what?.
STATUS EPILEPTICUS.
Plasma clearance of the anti-seizure drugs is relatively low T OR F??
T because the are mainly cleared by the the hepatic metabolism.
A prodrug when it is getting metabolized it becomes similar in actions to CARBAMAZEPINE but it has less induce metabolizing enzymes on other drugs , what is the name of the drug??
OXCARBAZEPINE
The CARBAMAZEPINE IS THE DRUG IF CHOICE TO TREAT BOTH THE PARTIAL SEIZURE AND GENERALIZED TONIC-CLONIC SEIZURE UNTIL NOW ,T OR F?
F,Because the newer agents displace it from this role.
What are the non-epileptic indications or use of CARBAMAZEPINE??
1/Trigeminal neurolagaia
2/Neuropathic pain
3/Bipolar depression
4/Manic-depressive illness.
Phenytoin is effective against many forms of partial seizure and generalized seizure also the Absence seizure T OR F?
F it int against absence seizure.
That drug is owned because of side effects and unpredictable pharmacokinetics behaviors it’s usage is declining,what is the drug?
Phenytoin because it’s kinetics are that it nonlinear kinetic which needs monitoring usually and Alison Narrow therapeutic index which means it reaches the toxicity faster.
Phenytoin is excreted directly to the urine after it metabolized in the liver T OR F?
F because phenytoin is first excreted in the bile then in the urine.
Which of the following drugs that inhabit the metabolism of PHENYTOIN? CIMETIDINE ISONIAZID A AND B RIFAMPIN
Both A AND B
Which of the following drugs induce the metabolism of PHENYTOIN? PHENOBARBITAL CIMETIDINE ISONIAZID NONE OF THE ABOVE
PHENOBARBITAL AND ALSO RIFAMPIN
PHENYTOIN induces the hepatic metabolism by enhancing CYP450 and decreasing the effects of other drugs what are these affected drugs?.
CARBAMAZEPINE
CLONAZEPINE
LAMOTRIGINE
BECAUSE ALL ARE METABOLIZED BY THIS ENZYMES SO THEIR METABOLITES WILL BE PRODUCED AND THE MAIN DRUG IS GONE AND THERE WILL BE NO EFFECTS.
SUCRALFATE makes a surface in the gastric so reducing the absorption of which drug?? CARBAMAZEPINE PHENYTOIN LAMOTRIGINE CIMETIDINE
Phenytoin
T OR F
If giving the carbamazepine and phenytoin together their effects will be reduced !
True because they both enhance the CYP450 and already metabolized by Tipton and gives their metabolites so no more effects are present.
An epileptic that is able to treat the ABSCNCE SEIZURE: PHENYTOIN VALPROIC ACID CARBAMAZEPINE CIMETIDINE
Vlaproic acid
Non-epileptic indications of VALPROIC ACID?
1/Manic episodes
2/Bipolar disorders
3/prophylaxis of migraine headache
Which of these inhibit the metabolism of phenobarbital and increase its level in blood?
VALPROIC ACID
