Anti Emetics

Question 1

Other name for promethazine?

Answer 1

Phenergan

Question 2

Black box warning for phenergan?

Answer 2

IV administration can cause severe tissue necrosis and should be avoided if possible. IV infusions should be stopped immediately if patient complains of pain.
IM injection is preferred route.

Question 3

What is MOA of phenergan? Common side effect?

Answer 3

Promethazine is an antihistamine first generation with side effect of sedation.

Question 4

Promethazine should be used with caution in which patients and why?

Answer 4

Phenergan has anticholinergic and antidopamine effects.

Anticholinergic properties are problematic for gastric ulcer, constipation, bowel obstruction, urinary retention, BPH

Anti dopamine effects can cause extrapyramidal, akathisia, dystonia effects