Anti-depressants 2 Flashcards
SNRIs do NOT have affect upon
Alpha-1 adrenergic, cholinergic, dopaminergic, or histaminergic receptors
(less side effects, but unique side effects)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/840/483/a_image_thumb.jpeg?1630879418)
Unique side effects of SNRI
Pseudocholinergic effects by stimulating NE or receptors in the SNS
(decrease parasympathetic tone)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/840/597/a_image_thumb.jpeg?1630879391)
Duloxetine inhibits _____ (enzyme)
CYP2D6
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/840/664/a_image_thumb.jpeg?1630879446)
SNRI adverse effects (class effects) (5)
- Nausea, dizziness, diaphoresis
- Blood pressure increase
- Headaches
- Sexual dysfunction
- Hyponatremia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/840/756/a_image_thumb.jpeg?1630879249)
In addition to treating depression Duloxetine also treats _____(4)
- Generalized anxiety disorder
- Diabetic peripheral neuropathic pain
- Fibromyalgia
- Chronic musculoskeletal pain
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/847/763/a_image_thumb.jpeg?1630879468)
In addition to treating depression, Milnacipran also treats ______
Fibromyalgia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/847/717/a_image_thumb.jpeg?1630879505)
Venlafaxine side effects
sexual dysfunction
(Most likely SNRI to cause this)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/840/856/a_image_thumb.jpeg?1630879362)
Two types of Tricyclic antidepressants
Tertiary or secondary amines
(tertiary has the methyl group)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/841/001/a_image_thumb.png?1630520358)
Tertiary amines effects (2)
- Highly anticholinergic
- Strong serotonin and norepinephrine reuptake inhibitor
(if this becomes too much, try the secondary Amine TCA)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/841/282/a_image_thumb.png?1630520408)
Secondary amine effects (3)
- less anticholinergic
- More potent
- More selective norepinephrine reuptake inhibitor
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/841/326/a_image_thumb.png?1630520451)
Tricyclic antidepressant MOA
Serotonin and norepinephrine reuptake inhibitor
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/841/365/a_image_thumb.png?1630520480)
TCAs block: (4)
- Blockade of muscarinic M1, H1, alpha-adrenergic 1 receptors
- fast Na Channel in cardiac cells
(they bind to everyhing!)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/841/403/a_image_thumb.jpeg?1630880307)
Which Tri cyclic antidepressants have the best overall tolerability (2)?
- Notriptlyin
- Desipramine
All cyclic antidepressants are potentially _____ toxic
cardio
________ may treat childhood enuresis (bed-wetting)
Imipramine
What are the three C’s of Tri cyclic antidepressants poisoning
- Convulsion
- Cardiac arrest
- Coma
Two types of monoamine oxidase inhibitors
- Hydrazine
- Non hydrazine
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/841/662/a_image_thumb.png?1630520985)
Monoamine oxidase is responsible for _____(2)
Breakdown of Serotonin and norepinephrine
The blockade of monoamine oxidase a in the gastrointestinal tract is responsible for the ______ reaction associated w/MOAIs
“cheese reaction” = hypertensive crisis
(A patient taking MOAIs and just foods containing the sympathomimetics tyramine)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/354/841/941/a_image_thumb.png?1630521092)
MOAIs are metabolized by ______ (process).
acetylation
MOAIs can also be effective in treating ______.
resistant depression
MOAIs have potent ____ effects
hypotensive (leading to dizziness)→risk in treating elderly
(also causes urinary hesitancy, headache and myoclonic jerks)