Anti depressants

Question 1

Major Depression Clinical features

Answer 1

2nd most common psychiatric disorder where the risk of suicide is high

• 2x more in women
• losss of pleasure
• illness

Question 2

major depression pathogenesis

Answer 2

monoamine- deficiency hypothesis

Question 3

Drugs for depression

Answer 3

SSRIs (selective serotonin reuptake inhibitors
- fluoxetine

2. SNRI (serotonin/norepinephrine Reuptake inhibitors)
   - venlafaxine
3. atypical antidepressants
   - bupropion
4. MAOIs (monoamine oxidase iinhibitors
   - phenelzine

Question 4

SSRI drug

Answer 4

fluoxetine

Question 5

fluxetine mech of action

Answer 5

A) normal cnditions: seotonin rapidly taken back into nerve
- termination of effect

B) with drug, upatake of setonin is blocked
- accumulation in synaptic space
- intensifying transmission

Question 6

Fluoxetine Therapeutic Uses

Answer 6

• major depression
• bipolar, ocd, bulimia nervosa

unlabed
- ptsd, adhd

Question 7

fluoxetine adverse effects

Answer 7

1) sexual dysfunction

2) serotonin syndrome

3) neonatal effects

4) bleeding disorders

Question 8

fluoxetine drug interactions

Answer 8

MAOIs and SSRIs are contraindicated

drugs that increase bleeding

Question 9

SNRI drug

Answer 9

venlafaxine

Question 10

therapeutic uses venlafaxine

Answer 10

similar to ssris

Question 11

mechanism of venlafaxine

Answer 11

increases serotonin and norepinephrine by clocking ruptake into post synamtic neuron

Question 12

valafaxine adverse effects

Answer 12

• anorexia
• hypertension
  -sexual disfunction
  -sustained mydriasis (dilation of pupil)

Question 13

Atypical antidepressant

Answer 13

bupropion

Question 14

bupropion mechanism of action

Answer 14

not clear. .. likely block reuptake of dopamine and nrephinephrine

Question 15

buprpion indications

Answer 15

1) major depression
2) SAD

Question 16

wellbutrin pharacokinetics

Answer 16

• PO
  -immediate-release tablets/ plasma peak in two hours
  -half-life 8-24 hours

Question 17

bupropion adverse effects

Answer 17

constipation
gi
insomnia

unique: blurred vision, tachycardia hallucinations, delusions

seizures

Question 18

bupropion drug interaction

Answer 18

avoid drugs that inhibit P450 enzymes
- can elevate bupropion levels

avoid MAOIs
- increased bupropion toxicity

Question 19

MAOIs drug

Answer 19

phenelzine

Question 20

mechanism of phenelzine

Answer 20

Monoamine oxidase (MOA) fxn
- remove norepinephrine, setonin and dpamine from the brain

A) drug free conditions much of NE and serotonin undergoes reuptake becomes inactivated by MAO

B) MAOIs inhibit MAO action
- increasing NE and serotonin inside neuron for further secretion

Question 21

Phenelzine adverse effects

Answer 21

hypertensive crises from dietary tyramine