Anti-cancer drugs SE pt2

Question 1

Erlotinib SE

Answer 1

Rash (looks like acne)**
Diarrhea
Anorexia and fatigue
Dyspnea
nail disorder
N/v

Question 2

Cetuximab SE

Answer 2

Acneiform rash
pruritus
nail changes
diarrhea
infusion related reactions

Question 3

Trastuzumab & Pertuzumab SE

Answer 3

Fever and chills
cardio toxicity

Question 4

Vemurafenib & Dabrafenib SE

Answer 4

non-melanoma skin cancers/ pre-cancerous lesions
photosensitivity
QT prolongation
Headache, fever
arthralgia

Question 5

Trametinib & Cobimetinib SE

Answer 5

cutaneous rash
acneiform dermatitis
diarrhea
photosensitivity
bleeding (Cobimetinib)

Question 6

Palbociclib SE

Answer 6

Neutropenia and infections
mucositis, diarrhea
fatigue, nausea
headache
anemia, thrombocytopenia

Question 7

bevacizumab SE

Answer 7

Hypertension
GI Perforation
thromboembolic events
hemmorage
proteinuria
delayed wound healing

Question 8

Nivolumab and Pembrolizumab SE

Answer 8

Immune-mediated
fatigue
dyspnea
musculoskeletal pain
decreased appetite
cough
nausea
constipation

Question 9

ipilimumab

Answer 9

immune related
- skin
- GI tract
- hepatitis
- hypophysitis
-hypo/hyperthyroidism

Question 10

tamoxifen SE

Answer 10

hot flashes
vaginal discharge
amenorrhea

Question 11

Goserelin, triptorelin, Leuprolide SE

Answer 11

hot flashes
night sweats
amenorrhea
decreased libido
reduced bone density
osteoporosis

Question 12

Fulvestrant SE

Answer 12

Injection site reaction
nausea
asthenia
pain
hot flashes
arthralgia
HA

Question 13

Anastrozole and letrozole ADR

Answer 13

estrogen depletion

Question 14

tamoxifen has more

Answer 14

hot flashes
vaginal bleeding/ dischage
endometrial cancer
VTE

Question 15

Anastrozole and letrozole has more

Answer 15

Arthragias
vaginal dryness
sexual dysfunction
loss of bone mineral density

Question 16

enzalutamide SE

Answer 16

fatigue
back pain
hot flashes
constipation
arthtagia
decreases appetite
diarrhea
hypertension
seizures

Question 17

Apalutamide

Answer 17

fatigue
hypertension
rash
nausea
hot flashes
weight loss
arthralgia
falls
decreases appetite
diarrhea
facture
peripheral edema
hypothyroidism
increased qt intervals
seizures

Question 18

DAroltamide

Answer 18

fatigue
pain in extremities
rash
ischemia heart disease
heart failure
urinary retention
pneumonia
hematuria
no seizures

Question 19

EGFR Inhibitors

Answer 19

Tyrosine kinase inhibitor
- erlotinib

Receptor blocker
- cetuximab

Question 20

HER2/Neu receptors

Answer 20

-Trastuzumab
-pertuzmab

-lapatinab

Question 21

RAF/BRAF inhibitors

Answer 21

-vemurafenib
-dabrafenib

Question 22

MEK Inhibitors

Answer 22

• Trametinib
• Cobimetinib

Question 23

Cycline- dependent kinase 4/6 inhibitors

Answer 23

palociclib

Question 24

VEGF inhibitor

Answer 24

bevacizumab

Question 25

PD-1 inhibitor

Answer 25

• nivolumab (fully human)
• Pembriolizumab (humanized)

Question 26

CTLA-4 inhibitor

Answer 26

Ipilimumab (fully human)

Question 27

SERMs

Answer 27

• Tamoxifen (prodrug)
• endoxifen

Question 28

GnRH analog/LHRH agonist

Answer 28

• goserelin
  -triptorelin
• leuprolide

Question 29

SERDs

Answer 29

Fulvestrant

Question 30

Aromatase inhibitors

Answer 30

exemestane (irreversible)

Anastrozole
Letrozole

Question 31

Anti-androgens

Answer 31

• enzalutamide
• apalutamide
• darolutamide

Question 32

CYP17A1 inhibitor

Answer 32

Abiraterone