anti-cancer drugs SE

Question 1

alkylating agent and platinum analogs

Answer 1

Myelosuppression
N/V/D
Alopecia
Mucositis
Infertility
Secondary malignancies
teratogenicity

Question 2

unique SE of cyclosphamide and ifosfamide

Answer 2

Hemmorhagic cystitis
- caused by acrolein
- prevented my mesna

Question 3

alkylating agent- Dacarbazine SE

Answer 3

Severe nausea and vomiting (highly emetogenic)

Question 4

alkylating agent- bendamustine

Answer 4

fever
rash
infusion related reaction

Question 5

which platinum analog causes the most myelosuppression

Answer 5

carboplatin

Question 6

which platinum analog causes the most nephrotoxicity

Answer 6

cisplatin

Question 7

which platinum analog causes the least myelosuppression ?

Answer 7

cisplatin (anemia)

Question 8

which platinum analog causes the least nephrotoxicity?

Answer 8

oxaliplatin

Question 9

which platinum analog causes the most peripheral neuropathy

Answer 9

cisplatin
oxaliplatin (chronic)

Question 10

which platinum analog causes the least peripheral neuropathy

Answer 10

carboplatin

Question 11

which platinum analog causes the most ototoxicity

Answer 11

cisplatin

Question 12

which platinum analog causes no ototoxicity

Answer 12

oxaliplatin

Question 13

which platinum analog causes no ?

Answer 13

cisplatin and carboplatin

Question 14

which platinum analog causes the most cold sensitivity or pharyngeal irritation?

Answer 14

oxaliplatin (acute)

Question 15

which platinum analog causes the most nausea and vomiting

Answer 15

cisplatin

Question 16

which platinum analog causes the least vomiting and nausea

Answer 16

carboplatin and oxaliplatin

Question 17

which platinum analog causes the most hypersensitivity

Answer 17

all equally

Question 18

cisplatin SE

Answer 18

nephrotoxicity
peripheral neuropathy
ototoxicity
N/V

Question 19

oxaliplatin SE

Answer 19

peripheral neuropathy
cold sensation
pharyngeal irritation

Question 20

how does cisplatin affect electrolytes

Answer 20

hypokalemia
hypomagnesium

Question 21

most common side effect of antimetabolites

Answer 21

myelosuppression
diarrhea*
mucositis*
alopecia
infertility

Question 22

antimetabolite- methotrexate SE

Answer 22

Liver toxicity *
mucositis
diarrhea
myelosuppression

prolonged in pts with third patient spacing

Question 23

antimetabolite- pemetrexed SE

Answer 23

skin rash (give dexamethasone )
had-foot syndrome
myelosupp
n/v/d
mucositis

Question 24

pyrimidine- 5-fu IV bolus SE

Answer 24

myelosuppression

Question 25

pyrimidine- 5-fu IV continuous SE

Answer 25

diarrhea hand foot syndrome

Question 26

capecitabine SE

Answer 26

diarrhea hand foot syndrome similar to continuous infusion 5-fu

Question 27

cytarabine SE

Answer 27

N/V/D Myelosuppression Mucositis

Question 28

Cytarabine high dose "HiDAC" SE

Answer 28

Cerebellar syndrome -dysarthria, nystagmus, ataxia -neuro checks before each dose Chemical conjunctivitis - prophylaxis steroid drops are used during HiDAC administration

Question 29

Gemcitabine (pyrimidine) SE

Answer 29

Flu like sx* N/V/D Myelosuppression Mucositis

Question 30

Fludarabine (purine) SE

Answer 30

myelosuppression immunosuppression

Question 31

anthracycline SE

Answer 31

extravasation/ vesicant red discoloration of tears, urine, sweat radiation recall cardio toxicity***

Question 32

vinka alkaloids SE

Answer 32

myelosupression peripheral neuropathy extravasation/vesicant

Question 33

which vinka alkaloid had the most myelosuppression

Answer 33

vinblastine

Question 34

which vinka alkaloid had the most peripheral neuropathy

Answer 34

vincristine

Question 35

Specific vincristine SE

Answer 35

motor neuropathy constipation foot drop

Question 36

paclitaxil toxicities

Answer 36

peripheral neuropathy hypersensitivity

Question 37

docetaxel toxicities

Answer 37

more myelosuppression fluid retention

Question 38

irinotecan toxicities

Answer 38

severe diarrhea myelosuppression N/V flushing, mucositis, increased LFTs, alopecia

Question 39

etoposide toxicities

Answer 39

infusion related reaction myelosuppression NVD mucositis peripheral neuropathy secondary leukemia***