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oncology > anti-cancer drugs SE > Flashcards

anti-cancer drugs SE Flashcards

1
Q

alkylating agent and platinum analogs

A

Myelosuppression
N/V/D
Alopecia
Mucositis
Infertility
Secondary malignancies
teratogenicity

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2
Q

unique SE of cyclosphamide and ifosfamide

A

Hemmorhagic cystitis
- caused by acrolein
- prevented my mesna

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3
Q

alkylating agent- Dacarbazine SE

A

Severe nausea and vomiting (highly emetogenic)

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4
Q

alkylating agent- bendamustine

A

fever
rash
infusion related reaction

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5
Q

which platinum analog causes the most myelosuppression

A

carboplatin

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6
Q

which platinum analog causes the most nephrotoxicity

A

cisplatin

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7
Q

which platinum analog causes the least myelosuppression ?

A

cisplatin (anemia)

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8
Q

which platinum analog causes the least nephrotoxicity?

A

oxaliplatin

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9
Q

which platinum analog causes the most peripheral neuropathy

A

cisplatin
oxaliplatin (chronic)

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10
Q

which platinum analog causes the least peripheral neuropathy

A

carboplatin

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11
Q

which platinum analog causes the most ototoxicity

A

cisplatin

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12
Q

which platinum analog causes no ototoxicity

A

oxaliplatin

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13
Q

which platinum analog causes no ?

A

cisplatin and carboplatin

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14
Q

which platinum analog causes the most cold sensitivity or pharyngeal irritation?

A

oxaliplatin (acute)

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15
Q

which platinum analog causes the most nausea and vomiting

A

cisplatin

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16
Q

which platinum analog causes the least vomiting and nausea

A

carboplatin and oxaliplatin

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17
Q

which platinum analog causes the most hypersensitivity

A

all equally

18
Q

cisplatin SE

A

nephrotoxicity
peripheral neuropathy
ototoxicity
N/V

19
Q

oxaliplatin SE

A

peripheral neuropathy
cold sensation
pharyngeal irritation

20
Q

how does cisplatin affect electrolytes

A

hypokalemia
hypomagnesium

21
Q

most common side effect of antimetabolites

A

myelosuppression
diarrhea*
mucositis*
alopecia
infertility

22
Q

antimetabolite- methotrexate SE

A

Liver toxicity *
mucositis
diarrhea
myelosuppression

prolonged in pts with third patient spacing

23
Q

antimetabolite- pemetrexed SE

A

skin rash (give dexamethasone )
had-foot syndrome
myelosupp
n/v/d
mucositis

24
Q

pyrimidine- 5-fu IV bolus SE

A

myelosuppression

25
Q

pyrimidine- 5-fu IV continuous SE

A

diarrhea
hand foot syndrome

26
Q

capecitabine SE

A

diarrhea
hand foot syndrome

similar to continuous infusion 5-fu

27
Q

cytarabine SE

A

N/V/D
Myelosuppression
Mucositis

28
Q

Cytarabine high dose “HiDAC” SE

A

Cerebellar syndrome
-dysarthria, nystagmus, ataxia
-neuro checks before each dose

Chemical conjunctivitis
- prophylaxis steroid drops are used during HiDAC administration

29
Q

Gemcitabine (pyrimidine) SE

A

Flu like sx*
N/V/D
Myelosuppression
Mucositis

30
Q

Fludarabine (purine) SE

A

myelosuppression
immunosuppression

31
Q

anthracycline SE

A

extravasation/ vesicant
red discoloration of tears, urine, sweat
radiation recall
cardio toxicity***

32
Q

vinka alkaloids SE

A

myelosupression
peripheral neuropathy
extravasation/vesicant

33
Q

which vinka alkaloid had the most myelosuppression

A

vinblastine

34
Q

which vinka alkaloid had the most peripheral neuropathy

A

vincristine

35
Q

Specific vincristine SE

A

motor neuropathy
constipation
foot drop

36
Q

paclitaxil toxicities

A

peripheral neuropathy
hypersensitivity

37
Q

docetaxel toxicities

A

more myelosuppression
fluid retention

38
Q

irinotecan toxicities

A

severe diarrhea
myelosuppression
N/V
flushing, mucositis, increased LFTs, alopecia

39
Q

etoposide toxicities

A

infusion related reaction
myelosuppression
NVD
mucositis
peripheral neuropathy
secondary leukemia***

40
Q
A

oncology (2 decks)

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