Anti-cancer 2

Question 1

Cyclophosphamide

Answer 1

Orally or intravenously
Lymphoma, leukemia, breast cancer +IMS to treat a
Hemorrhagic cystitis

Question 2

Cisplatin

Answer 2

Slow iv infusion 
Most efficacious against testicular cancer also used for lung and bladder cancer 
- skin lesion 
- N/V
nephrotoxicity and burning on urination 
Low myelotoxicity

Question 3

Carboplatin

Answer 3

Less N/C and nephrotoxicity

Higher myelotoxicity

Question 4

Methotrexate

Answer 4

Oral or IV or IM
breast, ALL 
Immunosuppressant to treat RT + SLE
N/V, diarrhea, BM suppression 
CI pregnancy

Question 5

5- fluorouracil

Answer 5

IV in combo w MTx
Colorectal cancer, breast, and others
BM depression and neurotoxicity

Question 6

6-Mercaptopurine

Answer 6

AML
IMS to treat Crohn’s disease and ulcerative colitis
Oral mucositis and diarrhea

Question 7

Vincristine

Answer 7

IV in combo w prednisone remission in children w leukemia
+ neurotoxicity
-BM depression
CI fatal if administered intrathecally

Question 8

Bin last one

Answer 8

IV in combo w cisplastin to treat lung cancer
+ BM depression
- neurotoxicity
CI fatal intrathecally

Question 9

Paclitaxel

Answer 9

IV infusion
For metastatic ovarian, breast, lung and neck cancer
Also as anti proliferative agent to prevent re stenosis in CA stents
Hypersensitivity

Question 10

Bleomycin

Answer 10

IV IM S.C
Hodgkin’s lymphoma and testicular cancer + bladder
Server skin hyper keratosis and pulmonary toxicity
Less IMS = and w cytotoxic drugs

Question 11

Doxorubicin

Answer 11

Breast, pancreas, bladder and prostate cancer
Hodge Kim’s and non Hodgkin’s lymphoma
Acute toxicity: N and red urine
Delay toxicity: cardio toxicity CHF (leg swelling and orthopnea)