Anti-anxiety Drugs

Question 1

altaprazolam

Answer 1

benzodiazepine; short elimination half-life; rebound anxiety; peak conc. 1-2hr; tx panic and GAD; aka Xanax

Question 2

chlordiazepoxide

Answer 2

benzodiazepine; less lipophilic- slower onset and redistribution; long elimination half-life; tx alcohol w/d

Question 3

clonazepam

Answer 3

benzodiazepine; less lipophilic- slower onset and redistribution; intermediate elimination half-life; tx panic and middle insomnia; or single dose acute anxiety

Question 4

diazepam

Answer 4

benzodiazepine; highly lipophilic- faster onset and redistribution; SHORT CLINICAL EFFECTS

Question 5

lorazepam

Answer 5

benzodiazepine; less lipophilic- slower onset and redistribution; intermediate elimination half-life; NOT METABOLIZED BY LIVER; tx panic, GAD, agitation

Question 6

temazepam

Answer 6

benzodiazepine; sleep aid for middle insomnia

Question 7

buspirone

Answer 7

partial 5-HT1A agonist; tx GAD only

Question 8

diphenhydramine

Answer 8

block histamine system for wakefulness; use as sleep aid

Question 9

zolpidem

Answer 9

benzo-like structure, higher affinity for GABA alpha1; controlled release

Question 10

zaleplon

Answer 10

benzo-like structure, higher affinity for GABA alpha1; NO HANGOVER; check for hepatic insufficiency; tx short-term insomnia

Question 11

eszopliclone

Answer 11

benzo-like structure, higher affinity for GABA alpha1; abuse potential; CYP3A4 inducer (beware ketaconazole)

Question 12

ramelteon

Answer 12

benzo-like structure, higher affinity for GABA alpha1; sleep aid; no abuse potential