Anti- Adrenergic Flashcards
List the adrenoreceptors at each organ/tissue
- iris
- ciliary body
- salivary glands
- lungs
- heart
- blood vessels
- in skeletal muscle
- in viscera - liver
- fat
- GIT
- GI sphincter
- bladder
- seminal tract
- uterus
Biosynthesis of catecholamines
Tyrosine – (tyrosinase)– DOPA – (dopa decarboxylase) – dopamine – (dopamine beta hydroxylase)– NA– (PNMT) – adrenaline
Biosynthesis of catecholamines
Tyrosine – (tyrosine hydroxylase)– DOPA – (dopa decarboxylase) – dopamine – (dopamine beta hydroxylase)– NA– (PNMT) – adrenaline
Name the 2 types of sympathomimetics
Direct vs indirect
Name indirect sympathomimetics
- MOAI moclobemide: inhibit degradation of NA/A
- TCA: block uptake-1 so increase NA/A in synaptic cleft
- Ephedrine & pseudoephrine: via uptake 1 into neuron & compete w NA/A for vesicular storage
Name indirect sympathomimetics
- MAOI moclobemide: inhibit degradation of NA/A
- TCA: block uptake-1 so increase NA/A in synaptic cleft
- Ephedrine & pseudoephrine: via uptake 1 into neuron & compete w NA/A for vesicular storage
how is endogenous catecholamine broken down?
- MAO
- mitochondria surface** of nerve term + liver + intestine
- NA– mainly MAO A
- dopamine – mainly MAO B - COMT
- found in all tissues
- breaks down most catechol & its by prdt
Name direct sympathomimetics, receptors, uses, major adverse effects
- NA
- A
- Dopamine
- oxymetazolime
- phenylephrine
- brimoidine
- isoprenaline
- dobutamine
- salbutamol/terbutaline
- mirabegron
Anti adrenergics/ sympatholytic drugs function to…
block NA/A action
2 classes of sympatholytic
direct & indrect
2 classes of sympatholytic
direct & indirect
Why beta 1 antagonist may be prefered eg atelenolol over propanolol?
1.
2.
3.
