Anti-adrenergic

Question 1

Alpha blocker ph action

Answer 1

1. BV: vasodilation, decrease TPR
2. B.P: decrease blood pressure
3. Postural hypertension
4. Eyes: miosis
5. Urigental: delayed ejaculation, micturition
6. Mis: nasal stuffiness

Question 2

Alpha blocker clinical uses:

Answer 2

1. Pheochromocytoma: post operative and chronic management; phenoxybenzamine, phentolamine

2.hypertension emergency:
Labetolol

3. Mild to mod. Hypertension:
   Prazosin
   Terazosin
   Trimazosin
4. Toxaemias of pregnancy:
   Labetolol
5. Raynauds phenomenon:-
   Prazosin + phenoxybenzomin
6. Urinary obstruction:
   Alfuzosin, prazosin
7. Erectile dysfunction:
   Yohimbine

Question 3

Beta blocker ph actions

Answer 3

CVS:
Decrease HR
Force of contraction
Excitability

BV: increase TPR

B.P: decrease B.P
Decrease renin release

Respiratory tract:
Increase airway constriction
Bronchoconstriction
Broncho spasm

Eye: decrease i/o pressure

Metabolic:
Decrease Glycogenolysis and glucagon secretion

Question 4

Beta blockers clinical indications

Answer 4

1. Hypertension:-
   Labetolol
2. IHD (angina pectoris)
   Decrease work load
3. Cardiac arrhythemias:
   Both ventricular & supra ventricular
4. Myocardial infarction:
   Prevent complications and reinfarction
   Prolong survival
5. Thyroid storm:-
   Propranolol is effective
6. Glaucoma:
   Timolol tropically
   Betaxolol
7. Aortic aneurysm
8. To decrease portal vein pressure
   In cirrhosis of liver
9. Heart failure:
   Metoprolol, carvedilol
10. Neurological conditions
    • migraine : timolol, atenolol
    • benign essential tremor
    • anxiety state
    • alcohol withdrawal symptoms

Question 5

Beta blocker adverse eff

Answer 5

1. Bradycardia
2. Bronchoconstriction
3. Worsening of hypoglycaemia
4. Salt and water retention
5. CNS: sedation, nightmare, depression