Anterior Pituitary Hormones - Park Flashcards
What hormone does the hypothalamus release in the thyroid track
TRH
What hormone does the anterior pituitary release in the thyroid track
TSH
What hormone does the hypothalamus release in the growth factor track
GHRH ( up regulates)
SST (down regulates)
What hormone does the anterior pituitary release in the growth factor track
GH
Growth Hormone Structure
protein hormone with 2 disulfide bonde
similar to prolactin
recombinant of rhGH
cleared by liver
Growth Hormone effects on body
anabolic on muscle - increasing lean muscle mass
catabolic in lipid cells - decrease weight
reduced insulin sensitivity > IGF-1 has some insulin activity
IGF1
insulin like growth factor 1
production increase mediates GH
mecasermin
treats IGF-1 deficiency
forms a complex with binding proteins
risk: hypoglycemia
GH antagonists
used to treat tumors on pituitary gland that cause acromegaly and gigantism
GH receptor antagonists
Somatostatin analogs
Somatostatin Analogs
Block GH release from the hypothalamus
Analogs used since somatostatin is cleared too rapidly
GH receptor Antagonist
pegvisomant
mutant form of GH with a high half life
octreotide
long activing, very potent GH inhibitor,
less potent insulin inhibitor
Gonadotropins
LH, FSH, hCG
shared alpha but distinct beta chain
menotropin
FSH + LH
urofollitropin
FSH only
LH is removed in purification
lutropin
rare
LH recombinant
helps with follicular development in infertile women
When to use gonadotropins
when clomiphene fails in infertility treatment
Closely monitor
Protocol for gonadotropin use
FSH - during follicular phase to prevent LH surge
hCG - act as LH to prompt ovulation
Progresterone - luteal phase
Male infertility
use LH and FSH
hCG 8 - 12 weeks
Ovarian hyperstimulation syndrome
caused by gonadotropin use
vascular hyperpermeability
GnRH analogs
“relins”
need pulsatile secretion to stimulate LH and FSH production
hypogonadism can occur if not pulsatile
less chance of multiple pregnancies
GnRH antagonists
“relix”
treat hyperstimulation and prostate cancer
Prolactin
lactation hormone
inhibited by dopamine
overproduction leads to inhibited GnRH release and low dopamine > decreased libido and infertility
