Anterior Pituitary Hormones - Park

Question 1

What hormone does the hypothalamus release in the thyroid track

Answer 1

TRH

Question 2

What hormone does the anterior pituitary release in the thyroid track

Answer 2

TSH

Question 3

What hormone does the hypothalamus release in the growth factor track

Answer 3

GHRH ( up regulates)

SST (down regulates)

Question 4

What hormone does the anterior pituitary release in the growth factor track

Answer 4

GH

Question 5

Growth Hormone Structure

Answer 5

protein hormone with 2 disulfide bonde
similar to prolactin
recombinant of rhGH
cleared by liver

Question 6

Growth Hormone effects on body

Answer 6

anabolic on muscle - increasing lean muscle mass
catabolic in lipid cells - decrease weight
reduced insulin sensitivity > IGF-1 has some insulin activity

Question 7

IGF1

Answer 7

insulin like growth factor 1

production increase mediates GH

Question 8

mecasermin

Answer 8

treats IGF-1 deficiency
forms a complex with binding proteins
risk: hypoglycemia

Question 9

GH antagonists

Answer 9

used to treat tumors on pituitary gland that cause acromegaly and gigantism
GH receptor antagonists
Somatostatin analogs

Question 10

Somatostatin Analogs

Answer 10

Block GH release from the hypothalamus

Analogs used since somatostatin is cleared too rapidly

Question 11

GH receptor Antagonist

Answer 11

pegvisomant

mutant form of GH with a high half life

Question 12

octreotide

Answer 12

long activing, very potent GH inhibitor,

less potent insulin inhibitor

Question 13

Gonadotropins

Answer 13

LH, FSH, hCG

shared alpha but distinct beta chain

Question 14

menotropin

Answer 14

FSH + LH

Question 15

urofollitropin

Answer 15

FSH only

LH is removed in purification

Question 16

lutropin

Answer 16

rare
LH recombinant
helps with follicular development in infertile women

Question 17

When to use gonadotropins

Answer 17

when clomiphene fails in infertility treatment

Closely monitor

Question 18

Protocol for gonadotropin use

Answer 18

FSH - during follicular phase to prevent LH surge
hCG - act as LH to prompt ovulation
Progresterone - luteal phase

Question 19

Male infertility

Answer 19

use LH and FSH

hCG 8 - 12 weeks

Question 20

Ovarian hyperstimulation syndrome

Answer 20

caused by gonadotropin use

vascular hyperpermeability

Question 21

GnRH analogs

Answer 21

“relins”
need pulsatile secretion to stimulate LH and FSH production
hypogonadism can occur if not pulsatile
less chance of multiple pregnancies

Question 22

GnRH antagonists

Answer 22

“relix”

treat hyperstimulation and prostate cancer

Question 23

Prolactin

Answer 23

lactation hormone
inhibited by dopamine
overproduction leads to inhibited GnRH release and low dopamine > decreased libido and infertility