Antenatal Care and Screening Flashcards

1
Q

Characteristics of morning sickness if pregnancy

A
  • Reasons unclear
  • Affects 80-85% women
  • Worse in conditions where HCG is higher e.g. twins, molar pregnancy
  • Can progress to hyperemesis gravidarium
  • Usually much better by week 16
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2
Q

What are the normal physiological cardiac out-put changes in pregnancy

A
  • CO increases by 30-50%
  • CO=SV x HR, HR increases from 70-90bpm
  • Palpitations common
  • At term, blood flow to uterus must exceed 1L/min
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3
Q

What are the normal physiological BP changes in pregnancy

A
  • Drops in the second trimester
  • Expansion of the uteroplacental circulation
  • A fall in systemic vascular resistance
  • Reduction in blood viscosity
  • Reduction in sensitivity to angiotensin
  • BP return to normal in 3rd trimester
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4
Q

What are the normal physiological changes to the urinary system in pregnancy

A
  • Bladder capacity reduced in 3rd trimester because of pressure
  • Increased urine output
    • Renal plasma flow increases 25-30%
    • Glomerular filtration rate increases by 50%
    • Serum urea and creatinine decrease - partly due to increased GFR and partly due to dilutional effect on increased plasma
  • UTI
    • Increase in urinary stasis
    • Hydronephrosis physiological in 3rd trimester and makes pyelonephritis common
    • Associated with preterm labour so needs treated
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5
Q

Normal physiological respiratory changes in pregnancy

A
  • Progesterone acts centrally - reduced CO2
    • Increased tidal volume
    • Increased respiratory
    • Increased plasma pH
  • O2 consumption increased by 20%
  • Plasma PO2 unchanged
  • Hyperaemia of resp mucous membranes
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6
Q

Normal physiological GI changes in pregnancy

A
  • Oesophageal peristalsis reduced
  • Gastric emptying slows
  • Cardiac sphincter relaxes
  • GI motility reduced due to
    • Increased progesterone
    • Decreased motilin
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7
Q

Who gets prepregnancy counselling

A
  • Ideally all women
  • Vital for women with previous health or pregnancy problems
  • In Scotland 1/3rd pregnancies unplanned
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8
Q

Primary care pre-pregnancy counselling

A
  • General health measures
    • Improve diet
    • Optimise BMI
    • Reduce alcohol consumption
  • Smoking cessation advice
  • Folic acid - 400mcg
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9
Q

What problems does obesity have in pregnancy

A
  • Higher rate of poorer outcomes
  • Affects function of uterus
  • Routine measurements difficult
  • Venous thromboembolic events more common
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10
Q

What problems does alcohol have in pregnancy

A
  • Foetal abnormalities
  • Foetal alcohol syndrome
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11
Q

What problems does age have in pregnancy

A
  • Teenagers more socially deprived, smoke more, book late, do not receive proper antenatal care
  • Older women (>40) have a higher chance of pre-existing medical conditions, develop more complications (gestational diabetes, hypertension etc.) an have dramatic increase in chances of chromosomal disorders
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12
Q

What problems does parity have in pregnancy

A
  • Pre-eclampsia is predominantly a condition of mull parity, occurring in the first pregnancy
  • Gran multiparity (4 or more) predisposes women to post-partum haemorrhage
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13
Q

What problems does occupation have in pregnancy

A
  • May put themselves or foetus at risk
  • Busy jobs with inadequate periods of rest, exposure to substances
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14
Q

What problems does substance misuse have in pregnancy

A
  • Mother may not see antenatal care
  • Heroin, methadone and benzodiazepine are addictive to the foetus and cause withdrawal syndrome at birth
  • Cocaine is associated with abruption resulting foetal death
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15
Q

Hoe does prepregnancy counselling help those with pre-existing medical conditions

A
  • Optimise maternal health
  • Psychiatric health important
  • Stop/change unsuitable drugs
  • Advise regarding complications associated with maternal medical problems
  • Occasional advise against pregnancy
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16
Q

Common previous maternal pregnancy problems

A
  • Counsel regarding risk of recurrence
    • C-section - after 2 customary to deliver this way
    • DVT
    • Pre-eclampsia
17
Q

Actions to reduce recurrence of previous maternal pregnancy problems

A
  • Thromboprophylaxis
  • Low dose aspirin
18
Q

Common previous foetal pregnancy problems

A
  • Counsel regarding risk of recurrence
    • Pre-term delivery
    • Intrauterine growth restriction
    • Foetal abnormality
19
Q

Action to reduce recurrence of previous foetal pregnancy problems

A
  • Treatment of infections
  • High dose of folic acid
  • Low dose aspirin
20
Q

What are the aims of antenatal examination

A
  • Mother
    • Problems - pre-existing or developing illness
    • ‘Minor’ problems such as anaemia
  • Foetus
    • Small gestational age
    • Foetal abnormality
  • Social
    • Support
    • Domestic violence
    • Psychiatric illness
21
Q

What is done in the antenatal examination

A
  • Routine enquiry - feeling well, foetal movements (20 wks)
  • Blood pressure - detect hypertension
  • Urinalysis - diabetes, UTI
  • Abdominal palpation
  • Foetal heartbeat
22
Q

What is done on abdominal palpation in antenatal examination

A
  • Assess symphyseal fundus
  • Height (SFH)
  • Estimate size
  • Estimate liquor volume
  • Asses lie
  • Determine presentation
    • If breech after 36 weeks offer external cephalic version
23
Q

What is antenatal screening

A
  • Offered to all women but not compulsory
  • Appropriate counselling prior important
  • Allows conditions to be detected and treated
24
Q

What infection screening is done in antenatal screening

A
  • Hep B - can provide passive and active immunisation for baby
  • Syphilis - treat with penicillin
  • HIV - maternal treatment and careful planning reduces transmission
  • MSSU - UTI
  • Rubella - up to 16 weeks, mental handicap, blindness deafness and heart defects
25
Q

Anaemia and isoimmunisation antenatal screening

A
  • Iron deficiency anaemia - common
    • bloods at 28/40 weeks
    • Iron tablets
  • Isoimmunisation
    • Rhesus disease - foetal anaemia can occur (can lead to foetal death)
    • Anti-c, anti-kell
26
Q

What can be screened for on first US scan

A
  • Ensure viable
  • Multiple pregnancy
  • Identify abnormalities incompatible for life
  • Down’s syndrome screening
27
Q

What is looked for on a detailed anomaly US scan

A
  • Systematic structural review of baby
  • Not possible to identify all problems
  • can identify problems that need intrauterine or postnatal treatment
28
Q

What is Down’s syndrome

A
  • Chromosomal abnormality
  • Characterised by 3 copies of chromosome 21
  • Overall risk - 1 in 700
29
Q

What is considered risk is considered high for Down’s syndrome

A
  • 1 in 150
  • Further testing offered
30
Q

How does risk for Down’s syndrome increase with age

A
  • Increases with age
  • 1 in 1667 - 20 years
  • 1 in 30 45 years
31
Q

What are the testing options offered for Down’s syndrome

A
  • Chorionic villus sampling (CVS) - 10-14 weeks, 1-2% risk
  • Amniocentesis - 15 weeks, 1% risk
  • Non-invasive prenatal testing
    • Maternal blood testing, detects foetal cell-free DNA
    • Can look for trisomies
    • Not offered on NHS
    • If high risk, invasive testing still recommended
32
Q

How is Down’s syndrome screened for in the first trimester

A
  • 10-40 weels
  • Maternal risk factors
  • Serum B-hCG
  • Pregnancy-associated protein A (PAPP-A)
  • Foetal nuchal translucency (NT) measurement
  • Detection rate = 90%, invasive rate = 5%
33
Q

How is the nuchal translucency measured

A
  • Taken between crown rump lengths of 45-84mm
  • Increases with gestation
  • Incidence of abnormalities related to size (not appearance)
34
Q

Screening for neural tube defect

A
  • Not routinely offered
  • Personal/family history - take 5mg folic acid
  • First trimester - detect anencephaly, spina bifida
  • Second trimester - biochemical screening
    • If unable to NT measurement
    • Maternal serum tested for alpha fetoprotein - <2 high
35
Q

What is the purpose of second trimester screening

A
  • Detecting foetal abnormality
  • Good screening test for structural abnormalities but poor for chromosomal