Ans9 Flashcards
Phenoxybenzamine
α-Adrenergic blocking agents
nonselective, noncompetitive blocker
prevents vasoconstriction
unsuccessful in maintaining lowered
blood pressure in hypertension
Phenoxybenzamine treat
treatment of sweating and hypertension associated with pheochromocytoma
Raynaud disease
frostbite
Phenoxybenzamine Adverse effects
postural hypotension, nasal stuffiness, nausea, and
vomiting
inhibit ejaculation
cardiac arrhythmias and anginal pain
reflex tachycardia
Yohimbine
selective competitive α2-blocker
increase sympathetic
treatment of erectile
dysfunction not recommended
Prazosin, terazosin, and doxazosin
selective competitive blockers of
the α1b receptor
treatment of hypertension
Tamsulosin and alfuzosin and silodosin
treatment of benign prostatic hyperplasia
(BPH).
decreases tone in the smooth muscle of
the bladder neck and prostate and improves urine flow.
more selective for α1A receptors in the prostate and
bladder
Adverse effects α1-Blockers
dizziness lack of energy, nasal congestion, headache,
drowsiness, and orthostatic hypotension
floppy iris syndrome
Phentolamine
competitive block of α1 and α2
4 hours after a single injection
diagnosis and short-term management of
pheochromocytoma
prevent dermal necrosis