Ans Receptors Flashcards
M1
Nerve endings; Gq - increase IP3 and DAG
M2
Heart; Gi - decrease cAMP and activates potassium channels
M3
Smooth muscle, gands, endothelium; Gq - increase IP3 and DAG
Nn
ANS ganglia; deplarizes through sodium potassium channel
Nm
Neurmuscular end plate; depolarizes through sodium postassium channel
Alpha1
smooth muscle, gands; Gq - increase IP3 and DAG; increase calcium - causes contraction or secretion
Alpha2
nerve endings; Gi - decrease cAMP; decreases transmitter release
Beta1
cardiac muscle, juxtaglomerular apparatus; Gs - increase cAMP increase heart rate and force, increases renin release
Beta2
smooth muscle, liver, heart; Gs - increases cAMP; relax smooth muscle. Increase glycogenolysis, increases heart rate and force
Beta3
Adipose cells; Gs - increase cAMP; increase lipolysis
Dopamine1
Smooth muscle; Gs - increase cAMP; relax renal vascular smooth muscle
Alpha 1 targets
mydriasis (contracts radial muscle); contracts splanchnic and skeletal muscle vessels; contracts GI and genitourinary sphincters; contracts uterus; causes ejaculation; contracts pilomotor smooth muscle; increases apocrine secretion; gluconeogenesis ang glycogenolysis
Beta1 targets
relaxes ciliary muscles; accelerates SA node; accelerates ectopic pacemakers; increases contractility; stimulates renin release
Beta2 targets
relaxes ciliary muscles; accelerates SA node; accelerates ectopic pacemakers; increases contractility; relaxes skeletal muscle vessels; relaxes GI smooth muscle; relaxes bronciolar smooth muscle; relaxes bladder wall; relaxes uterus; gluconeogenesis; glycogenolysis
M1 targets
activates myenteric plexus; erection