ANS Pharmacology I: Drug Action at Autonomic Receptors Flashcards
botulinum toxin
Acts on cholinergic nerve terminal
Enzymes that cleave cholinergic nerve terminal proteins and block ACh release
treats muscle spasm, smooth wrinkles, and reduce excessive sweating
edrophonium
acts on AChE
Readily reversible inhibitor of AChE-
used in reversal of neuromuscular block by nondepolarizing drugs; diagnosis of myasthenia gravis
pyridostigmine
- acts on AChE-
Quarternary ammonium carbamate ester AChE inhibitor
treatment of myasthenia gravis
acetylcholine
acts on nAChR
cholinergic agonist (muscarinic/nicotinic)
used in cataract (and certain other eye) surgery
succinylcholine
acts on nAChR
partial nicotinic agonist
depolarizing neuromuscular blocker- N-M relaxation
tubocurarine chloride (d-tubocurarine)
acts on nAChR
competitive agonist at skeletal muscle nictotinic receptors
N-M relaxation
dantrolene
Ryanodine receptor agonist; blocks Ca2+ release
counteracts succinylcholine-induced malignant hyperthermia
treats malignant hyperthermia
acetylcholine
muscarinic receptor agonist- cholinergic agonist (both muscarinic and nicotinic)-
used in cataract (and other eye surgery)
cevimeline
M3-selective muscarinic agonist
treats Sjoegren’s syndrome
methacholine
Non-selective muscarinic agonist
Diagnosis of airway hyperreactivity
atropine
non-selective muscarinic receptor antagonist
treats: mydriatic, cycloplegic; reversal of vagal bradycardia; antidote for cholinesterase inhibitor toxicity
darifenacin
M3 selective muscarinic receptor antagonist
treats incontinence; overactive bladder
ephedrine
acts on adrenergic nerve terminal- mixed acting sympathomimetic (causes NE release from terminals and is an adrenergic receptor agonist)
treats hypotension; bronchospasm; nasal decongestant
methyldopa (alpha-methyldopa)
acts on adrenergic nerve terminal converted to methylnorepinephrine in CNS, which acts like alpha2 agonist
treats hypertension
albuterol
beta 2 selective adrenergic agonist
prompt treatment for acute bronchospasm
clonidine
adrenergic agonist at alpha 2 selective receptors in the CNS, this results in decreased sympathetic outflow-
treats hypertension
dobutamine
beta 1 selective adrenergic agonists
treats: increase cardiac output in acute heart failure
dopamine
adrenergic agonist- dopamine agonist (also alpha beta agonist)
treats shock, especially with renal shutdown;
sometimes used in heart failure
epinephrine
adrenergic agonist
treats anaphylaxis; emergency treatment of cardiac arrest
isoproterenol
non-selective beta-adrenergic agonist
treats acute asthma; emergency treatment of cardiac arrest
- midodrine
alpha 1 selective adrenergic agonist
treats chronic orthostatic hypertension
phenylephrine
alpha adrenergic agonist
treats: decongestant, mydriatic, neurogenic hypotensionn, test of baroreflex
carvedilol
adrenergic antagonist at the alpha 1 and beta receptors
treats hypertension; heart failure
metoprolol
adrenergic antagonist at beta 1 selective antagonist
treats hypertension; heart failure
phentolamine
alpha adrenergic antagonist
treats pheochromocytoma, antidote to overdose of adrenergic agonist
prazosin
alpha 1 selective adrenergic antagonist
treats hypertension, benign prostatic hyperplasia
propranolol
non-selective beta adrenergic receptor antagonist
treats angina, arrhythmias (treatment and prophylaxis), hypertension, tremor, anxiety, migraine
