ANS & NT Flashcards
division of ANS
symph- prepare for heightened activity parasymph- stimulates abdominal activity
somatic & ANS
efferent division differ in: neural efferent pathway effector organs organ response neurotransmitter
peripheral neuron
1. lower motor
location of cell body- motor nucleus in anterior gray horn of spinal cord or brainstem nucleus
NT released- ACh
effect= always excitatory
- preganglionic
location of cell bodies- motor nucleus in lateral gray horn or brainstem nucleus
NT released- ACh
effect- excitatory
3.postganglionic
location- peripheral ganglion
NT released- Ach or NA
effect= excitatory or inhibitory
symph & parasymph NS comparison
similarities: serve same organs
involve pre and post ganglionic neuron
pre neuron release ACh
presence of ganglia
differences:
location of pre cell bodies and axon exit point
length of axons
location of ganglia
parasymph
pre neuron arise from opposite ends of CNS - brain stem exit via cranial nerves -sacral region exit via spinal nerves pre axon-long post axon-short post NT=ACh
symph
pre fibres arise within spinal cord T1-L2
- cell bodies in motor nuclei of lateral gray horn
-axons exit spinal cord via spinal nerves
pre axon- short
post axon-long
post NT= NA
NT receptors
ACh bind to cholinergic 2 subtypes: nicotinic & muscarinic NA bind to adrenergic 2 subtypes: a & b
cholinergic receptors
nicotinic= exit
muscarinic=exit/ inhib
adrenergic receptors
beta 1 (heart)=exit beta 2 (heart, liver, skeletal muscle) inhib alpha 1 (symp target)= exit
postynpathic potentials
EPSP
- NT binds receptors on postsynaptic membrane
- opens gated ion channels
- graded depolarisation
- postsynaptic cell excited membrane potential closer to threshold
- AP more likely to occur
- increased target activity
IPSP
- NT binds receptors on postsynaptic membrane
- opens gated ion channels
- graded hyperpolarisation
- postsynaptic cell inhibited membrane potential further to threshold
- AP less likely to occur
- decreased target activity
agonist
drug that mimic the action of NT
antagonist
drug that bind to receptor and block the action of the NT