ANS drugs Flashcards
Norepinephrine: Therapeutic class?
Vasopressor/vasoconstrictor
Norepinephrine: How does it work?
Stimulates peripheral alpha-1 adrenoceptors, causing VASO AND VENOconstriction
Some weak stimulation of beta-1 receptors in the heart increasing HR and contractility
Norepinephrine oral fraction?
100%
Norepinephrine mode of administration?
IV only
Norepinephrine is metabolized by which organ? How is it excreted?
metabolized by COMT and MAO in the liver. Metabolites are excreted in the urine.
What is the half life of norepinephrein?
1-2 minutes. Can cross placenta but not blood brain barrier
Epinephrine: Therapeutic class?
Vasopressor, cardiac stimulant, bronchodilator, anaphylactic treatment, adjunct to local anesthetics
How does epinephrine work (pharmacodynamics)?
Stimualtes peripheral alpha 1 adrenoreceptors, Beta-1 receptors (HR and contractility) and Beta 2 receptors (bronchodilation)
What are the routes of administration of Epinephrine?
IV, intramuscular (IM), subcutaneous (SC) and inhalation, and ophthalmic topical.
How is epinephrine metabolized?
Metabolized by COMT and then excreted by the urine
What are the toxic effects of epinephrine?
excessive vasoconstriction, HTN, hemorrhagic stroke, angina, arrhythmias
What are the drug interactions of epinephrine?
Risk of excessive hypertension in patients taking propranolol
What should you monitor with epinephrine?
BP, HR, rhythm, infusion site, evidence of extravasation
