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Pharmacology > ANS > Flashcards

ANS Flashcards

1
Q

Anesthesia cart drugs 19

A

Atropine, glyco, scopolamine, ipratropium, ephedrine, epi, norepi, dopamine, dobutamine, isoproterenol, neosynephrine, albuterol, prazosin, phentolamine, propranolol, metoprolol, atenolol, esmolol, labetolol

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2
Q

Neuron myelination: preganglionic, postganglionic

A

Pre myelinated, post unmyelinated

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3
Q

SNS

Where preganglionic neuron cell bodies are located

A

T1-L2/3 spinal cord, intermediolateral horn grey matter

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4
Q

SNS where postganglionic neuron cell bodies are

A 
Paravertebral chains on either side of spinal column 
Paravertebral ganglia (celiac, superior, inferior, mesenteric in abd)
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5
Q

SNS pre/postganglionic neuron length

A

Short pre

Long post

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6
Q

PSNS

Pre ganglionic neuron location

A

Cranial- medullary- CN 3, 7, 9, 10

Sacral- spinal cord- S2-4

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7
Q

PSNS post ganglionic neuron cell body location

A

Target organs. Ganglia in head and neck (ciliary ganglia)

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8
Q

PSNS neuron cell length pre/post ganglionic

A

Long pre, short post

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9
Q

SNS vs PSNS action to eye

A

SNS- dilation

PSNS- constriction

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10
Q

SNS vs PSNS salivary glands

A

SNS- decreased bf and secretions, dries

PSNS- secretions made

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11
Q

Lacrimal gland pns

A

Able to cry

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12
Q

SNS

Vessels in head and neck

A

Constrict in skin, no constriction to brain

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13
Q

SNS

Heart

A

Stronger contraction, faster rate, higher 02 demand. Blood return to heart increased via constriction in legs/skin/sphlancnic beds

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14
Q

PNS

Heart

A

Some innervation, SA node rate decreased from vagus

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15
Q

SNS vs PNS

Lungs

A

Bronchodilation B2 receptors.

Bronchoconstriction

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16
Q

SNS adrenal medulla

A

B2 receptors, epi released from here

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17
Q

SNS

Liver

A

Increase glucose release, glycogenolysis, lipolusis, insulin increases (to uptake glucose by muscle)

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18
Q

SNS
GI tract
Vessels everywhere

A

Sphincters contracted

Depends where. B2- dilation. A1- constriction.

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19
Q

PNS

GI

A

Motile, inc gastric acid secretion and pancreatic enzymes

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20
Q

PNS

Bladder

A

Detrusor gains tone, sphincter loses tone, able to void

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21
Q

Organs innervated by both systems: 3

A

Gi, cardiac muscle, bladder

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22
Q

Only innervated by sns: 2

Only innervated by PSNS: 2

A

SNS: sweat glands, blood vessels (muscarinic receptors tho)
PSNS: ciliary eye muscle, bronchial smooth muscle (B2 receptors tho)

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23
Q

Receptors can be present in a tissue and not be ____. If this is case, receptor can only respond when what

A

Innervated. Drug or hormone is circulating in the blood.

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24
Q

SNS

__ response with ___ innervation. 3 stim

A

Amplification, diffuse. Postural changes, exercise, emergency response

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25
Q

PSNS

__ and ___ __ responses

A

Discrete, narrowly targeted

26
Q

Both systems exhibit __ __ at rest. Heart rate: __ predominance, blood vessels: ___ tone

A

Baseline tone
Vagal
SNS

27
Q

Somatic efferent muscle
Receptor
What works here

A

ACh nicotinic on skel muscle

Muscle relaxers

28
Q

SNS
Receptors in blood vessels
Never releases what, always what

A

ACh nicotinic to norepi in vessel

Never epi, always norepi

29
Q

SNS

Sweat gland receptors

A

ACh nicotinic on a ACh muscarinic on gland.

30
Q

SNS

Adrenal medulla receptor

A

ACh nicotinic

31
Q

PNS receptors

A

ACh (nicotinic) on an ACh (muscarinic) in location

32
Q

PSNS cholinergic receptors:

A

Nicotinic ACh: Nm, Nn

Muscarinic ACh: M1-5

33
Q

PSNS Adrenergic receptors

A

A1, A2

B1, B2, B3

34
Q

3 Overall anomalies in pns

A

Adrenal medulla, sweat glands, blood vessels

35
Q

How adrenal medulla is an anomaly

A

Acts like ganglia but releases ne and epi as hormones. 20% NE, 80% epi

36
Q

How sweat glands are an anomaly

A

Innervated anatomically by SNS. Post ganglionic nerve releases Ach on a muscarinic Ach receptor. Sympathetic cholinergic fiber

37
Q

How blood vessels are an anomaly

A

No PSNS innervation but there are muscarinic ach receptors present. They activate w/NO and dilate if Ach circulating

38
Q

M1 (Ach)
Receptor
Signal

A

Gaq

Excitatory CNS, modulatory ganglia

39
Q

M1 (Ach)

2nd messengers

A

PLC activated
IP3 and DAG
PKC and inc Ca
Decreased K conductance

40
Q

M1
What NT
Physiologic response

A

Acetylcholine

Inc CNS activity, modulation at ganglia

41
Q

M2 (Ach)
Receptor
Signal

A

Gai

Inhibitory cardiac

42
Q

M2 (Ach)

2nd messenger

A

Inhibit Adenylate cyclase
Decrease cAMP
Increase K conductance

43
Q

M2
NT
Physio response

A

Ach

Decreased cAMP slows HR and decreases contractility

44
Q

M3 (Ach)
Receptor
Signal

A

Gaq

Excitatory smooth muscle and glands

45
Q

M3 Ach

2nd messengers

A

PLC activated
IP3 and DAG
PKC and inc Ca

46
Q

M3
NT
Physio response

A

Ach

Smooth muscle contraction

47
Q

Nn (Ach)
Receptor
Signal

A

Ligand gated ion channel

Excitatory ganglia CNS

48
Q

Nn (Ach)

2nd messengers

A

Increased K and Na permeability

49
Q

Nn
NT
Physio response

A

Ach

Depolarization

50
Q

Nm (ACH)
Receptor
Signal

A

Ligand gated ion channel

Excitatory NMJ

51
Q

Nm (Ach)

2nd messengers

A

Increased Na and k permeability

52
Q

Nm
NT
Physio response

A

ACH

Depolarization

53
Q

A1 (epi/NE)
Receptor
Signal

A

Gaq

Excitatory blood vessels

54
Q

A1 (epi/NE)

2nd messengers

A

PLC activated
IP3 and DAG
PKC and inc Ca

55
Q

A1
NT
Physio response

A

NE, epi

Smooth muscle vasoconstriction

56
Q

A2 (NE, epi)
Receptor
Signal

A

Gai

Inhibitory blood vessels pre-synaptic CNS, post synaptic

57
Q

A2 (NE, epi)

2nd messengers

A

Inhibit Adenylate cyclase
Decrease cAMP
Increase K conductance

58
Q

A2
NTs
Physio response

A

NE, epi

Decreased CAMP leads to Increased smooth muscle contraction, hyperpolarization inc K

59
Q

B1, 2, 3 (epi, norepi)
Receptor
Signal

A

Gas

Excitatory or inhibitory depending on cAMP

60
Q

B1, 2, 3

2nd messengers

A

Activate Adenylate cyclase

Increase cAMP

61
Q

B1, 2, 3
NTs
Physio response

A

NE, Epi

Increased cAMP relaxes smooth muscle, stim cardiac contractility, increases rate

Pharmacology (19 decks)

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