ANS Flashcards
Anesthesia cart drugs 19
Atropine, glyco, scopolamine, ipratropium, ephedrine, epi, norepi, dopamine, dobutamine, isoproterenol, neosynephrine, albuterol, prazosin, phentolamine, propranolol, metoprolol, atenolol, esmolol, labetolol
Neuron myelination: preganglionic, postganglionic
Pre myelinated, post unmyelinated
SNS
Where preganglionic neuron cell bodies are located
T1-L2/3 spinal cord, intermediolateral horn grey matter
SNS where postganglionic neuron cell bodies are
Paravertebral chains on either side of spinal column Paravertebral ganglia (celiac, superior, inferior, mesenteric in abd)
SNS pre/postganglionic neuron length
Short pre
Long post
PSNS
Pre ganglionic neuron location
Cranial- medullary- CN 3, 7, 9, 10
Sacral- spinal cord- S2-4
PSNS post ganglionic neuron cell body location
Target organs. Ganglia in head and neck (ciliary ganglia)
PSNS neuron cell length pre/post ganglionic
Long pre, short post
SNS vs PSNS action to eye
SNS- dilation
PSNS- constriction
SNS vs PSNS salivary glands
SNS- decreased bf and secretions, dries
PSNS- secretions made
Lacrimal gland pns
Able to cry
SNS
Vessels in head and neck
Constrict in skin, no constriction to brain
SNS
Heart
Stronger contraction, faster rate, higher 02 demand. Blood return to heart increased via constriction in legs/skin/sphlancnic beds
PNS
Heart
Some innervation, SA node rate decreased from vagus
SNS vs PNS
Lungs
Bronchodilation B2 receptors.
Bronchoconstriction
SNS adrenal medulla
B2 receptors, epi released from here
SNS
Liver
Increase glucose release, glycogenolysis, lipolusis, insulin increases (to uptake glucose by muscle)
SNS
GI tract
Vessels everywhere
Sphincters contracted
Depends where. B2- dilation. A1- constriction.
PNS
GI
Motile, inc gastric acid secretion and pancreatic enzymes
PNS
Bladder
Detrusor gains tone, sphincter loses tone, able to void
Organs innervated by both systems: 3
Gi, cardiac muscle, bladder
Only innervated by sns: 2
Only innervated by PSNS: 2
SNS: sweat glands, blood vessels (muscarinic receptors tho)
PSNS: ciliary eye muscle, bronchial smooth muscle (B2 receptors tho)
Receptors can be present in a tissue and not be ____. If this is case, receptor can only respond when what
Innervated. Drug or hormone is circulating in the blood.
SNS
__ response with ___ innervation. 3 stim
Amplification, diffuse. Postural changes, exercise, emergency response
PSNS
__ and ___ __ responses
Discrete, narrowly targeted
Both systems exhibit __ __ at rest. Heart rate: __ predominance, blood vessels: ___ tone
Baseline tone
Vagal
SNS
Somatic efferent muscle
Receptor
What works here
ACh nicotinic on skel muscle
Muscle relaxers
SNS
Receptors in blood vessels
Never releases what, always what
ACh nicotinic to norepi in vessel
Never epi, always norepi
SNS
Sweat gland receptors
ACh nicotinic on a ACh muscarinic on gland.
SNS
Adrenal medulla receptor
ACh nicotinic
PNS receptors
ACh (nicotinic) on an ACh (muscarinic) in location
PSNS cholinergic receptors:
Nicotinic ACh: Nm, Nn
Muscarinic ACh: M1-5
PSNS Adrenergic receptors
A1, A2
B1, B2, B3
3 Overall anomalies in pns
Adrenal medulla, sweat glands, blood vessels
How adrenal medulla is an anomaly
Acts like ganglia but releases ne and epi as hormones. 20% NE, 80% epi
How sweat glands are an anomaly
Innervated anatomically by SNS. Post ganglionic nerve releases Ach on a muscarinic Ach receptor. Sympathetic cholinergic fiber
How blood vessels are an anomaly
No PSNS innervation but there are muscarinic ach receptors present. They activate w/NO and dilate if Ach circulating
M1 (Ach)
Receptor
Signal
Gaq
Excitatory CNS, modulatory ganglia
M1 (Ach)
2nd messengers
PLC activated
IP3 and DAG
PKC and inc Ca
Decreased K conductance
M1
What NT
Physiologic response
Acetylcholine
Inc CNS activity, modulation at ganglia
M2 (Ach)
Receptor
Signal
Gai
Inhibitory cardiac
M2 (Ach)
2nd messenger
Inhibit Adenylate cyclase
Decrease cAMP
Increase K conductance
M2
NT
Physio response
Ach
Decreased cAMP slows HR and decreases contractility
M3 (Ach)
Receptor
Signal
Gaq
Excitatory smooth muscle and glands
M3 Ach
2nd messengers
PLC activated
IP3 and DAG
PKC and inc Ca
M3
NT
Physio response
Ach
Smooth muscle contraction
Nn (Ach)
Receptor
Signal
Ligand gated ion channel
Excitatory ganglia CNS
Nn (Ach)
2nd messengers
Increased K and Na permeability
Nn
NT
Physio response
Ach
Depolarization
Nm (ACH)
Receptor
Signal
Ligand gated ion channel
Excitatory NMJ
Nm (Ach)
2nd messengers
Increased Na and k permeability
Nm
NT
Physio response
ACH
Depolarization
A1 (epi/NE)
Receptor
Signal
Gaq
Excitatory blood vessels
A1 (epi/NE)
2nd messengers
PLC activated
IP3 and DAG
PKC and inc Ca
A1
NT
Physio response
NE, epi
Smooth muscle vasoconstriction
A2 (NE, epi)
Receptor
Signal
Gai
Inhibitory blood vessels pre-synaptic CNS, post synaptic
A2 (NE, epi)
2nd messengers
Inhibit Adenylate cyclase
Decrease cAMP
Increase K conductance
A2
NTs
Physio response
NE, epi
Decreased CAMP leads to Increased smooth muscle contraction, hyperpolarization inc K
B1, 2, 3 (epi, norepi)
Receptor
Signal
Gas
Excitatory or inhibitory depending on cAMP
B1, 2, 3
2nd messengers
Activate Adenylate cyclase
Increase cAMP
B1, 2, 3
NTs
Physio response
NE, Epi
Increased cAMP relaxes smooth muscle, stim cardiac contractility, increases rate