ANS Flashcards
M1, 3, 5 : Result of ligand Binding
Gq + PLC
Formation of IP3( increaes intracellular calcium) and DAG (increases PKC)
M2,4: Result of Ligand Binding
Gi
Opening of Potassium channels and inhibition of adenylyl cyclase
M1 location
CNS NEURONS, sympathetic postganglionic neurons, some presynaptic sites;
Gastric parietal cells
M2 receptor locations
myocardium, smooth muschle, some presynaptic sites; CNS neurons
M3 receptor sites
Exocrine glands, vessels (sm. muscle and endothelium); CNS neurons
Pupillary sphincter muscle contraction (miosis) and ciliary contraction (accomodation)
M4 receptor sites
CNS neurons; possibly vagal nerve endings
M5 receptor locations
Vascular endothelium, especially cerebral vessels; CNS neurons
Nn locations
Autonomic System
Postganglionic neurons, some presynaptic cholinergic terminals
Adrenal gland (Chromaffin cell)
Nm locations
Somatic System
skeletal muscle neuromuscular end plates
Alpha receptors (1&2) locations
Vascular smooth muscle, presynaptic nerve terminals and platelets and in the brain
Beta receptor locations (1-3)
most types of smooth muscle, cardiac muscle, some presynaptic nerve terminals and in the brain
alpha 1 Receptor ligand binding effect
Gq activates PLC leading to increased DAG and IP3/Ca
alpha2 Receptor ligand binding effect
Gi inhibits AC leading to decreased cAMP
Gi activates K+ channel leading to hyperpolarization
Beta 1-3 receptor ligand binding effect
Gs activates AC and increases cAMP. Beta 2 activates Gi under some conditions
alpha 1 location
Postsynaptic effector cells, especially smooth muscles
Effector Organs: Arterioles in skin, mucosa, viscera, kidney (Resistance Vessels)
Veins, Uterus and Spleen
