ANS Flashcards
neurotransmitters of ANS
norepinephrine
acetylcholine
norepinephrine receptors
alpha and beta
acetylcholine receptors
muscarinic and nicotinic
alpha-1 effects on what tissue and with what action
-vascular smooth muscle- contraction
-pupillary dilator muscles-contraction (dilate
pupil)
-pilomotor smooth muscle-erects hair
-prostate-contraction
-heart-increase force of contraction
(increase HR)
alpha 2
tissue-effects
-platelets-aggregation
-adrenergic and cholinergic nerve terminals-
inhibition of transmitter release
-some vascular smooth muscle-contraction
-fat cells-inhibition of lipolysis
Beta-1
tissue-effects
-heart-increases force and rate of
contraction (increase HR)
Beta-2
tissue-effects
-respiratory, uterine, and vascular smooth
muscle-promotes smooth muscle
relaxation
-skeletal muscle-promotes potassium
uptake
-liver-activates glycogenolysis (increases BS)
Alpha-1 Agonists medications
-midodrine
-naphazoline
midodrine indication
orthostatic hypotension
naphazoline indication
reduce redness in eyes
Alpha-1 adverse effects
supine htn, piloerection (goosebumps)
Alpha-2 agonist medication
clonidine, guanfacine, methyldopa
clonidine indications
htn, add/adhd in children, opioid withdrawal symptoms
guanfacine indications
htn, add/adhd in children
methyldopa indication
htn
Alpha-2 agonists adverse effects
-drowsiness, fatigue, dizziness
-orthostatic hypotension
-rebound htn if d/c abruptly
Alpha-1 Antagonist indications
htn, bph
Alpha-1 Antagonists medications
-doxazosin, terazosin, prazosin- less selevtive- htn
-tamsulosin, alfuzosin, silodosin-more selective-bph
Alpha-1 Antagonist adverse effects
orthostatic hypotension, fluid retention, dizziness, headache, fatigue
Beta-2 Agonist medications
albuterol, levalbuterol, salmeterol, formoterol
