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Pharmacology > Ans > Flashcards

Ans Flashcards

1
Q

Selective M1 antagonist

A

Pirenzepine & telenzepine

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2
Q

Selective M2 antagonist

A

Methoctramine & Tripitramine

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3
Q

Selective M2 agonist

A

Methacholine

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4
Q

Selective M3 agonist

A

Bethanechol

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5
Q

M3 antagonist

A

Darifenacin & solefenacin

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6
Q

Nm receptor agonist

A

PTMA

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7
Q

Nm receptor antagonist

A

Tubocurarine

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8
Q

Nn receptor agonist

A

DMPP

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9
Q

Nn receptor antagonist

A

Hexamethonium

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10
Q

Pilocarpine used as

A
  1. Rx open angle glaucoma (3rd choice)
  2. Miotic to counteract midriatic used for refraction test
  3. Break irido-lens & irido-corneal adhesions
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11
Q

AntiChe in Alzheimer’s

A

Rivastigmine, donepezil, galantamine

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12
Q

First line drugs in myasthenia gravis

A

Neostigmine, physostigmine

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13
Q

Myasthenia crisis is managed by

A

Tracheal intubation & mechanical ventilation

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14
Q

Edrophonium use

A

Diagnosis of myasthenia gravis

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15
Q

Varenicline is

A

a4b2 subtype Nicotine receptor agonist

Used in smoking cessation

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16
Q

Contraction of dilator pupillae

A

Adrenergic agonists (Active mydriasis )

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17
Q

Relaxation of dilator pupilae

A

Adrenergic blockers (passive miosis )

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18
Q

Uses of AntiChesterases

A

1 Miotic 2. Myasthenia gravis 3. Post-op paralytic ileus/ urinary retention 4. Postop decurarization 5. Alzheimer’s 6. Belladona poisoning 6. Drug overdose ( TCA, antihistamines)

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19
Q

Opp poisoning Rx

A
  1. Atropine 2. Pralidoxime 3.wash skin, lavage, patent airway,BP,hydration, convulsions
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20
Q

Antich esterases used in Alzheimer’s

A

Rivastigmine,Donepezile, Galantomine

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21
Q

Rx myasthenia gravis

A
  1. Neo/ pyridostigmine
  2. Thymectomy
  3. Glucocorticoid
  4. Immunosuppressant
  5. Plasmapheresis
22
Q

Muscarinic side effects

A 
S salivation
L lacrimation
U urinary incontinence 
D diarrhoea
G hi distress
E emetics
Bradycardia 
Miosis
23
Q

Atropine poisoning Rx

A

Gastric lavage with tannic acid
Keep in dark quite room
Rest Rx mostly symptomatic
Or neostigmine (but cns effects aren’t antagonized)
Or physostigmine (but s/e hypotension arrhythmia)

24
Q

Smoking cessation Rx

A
  1. Nicotine patch or chewing gum
  2. Varenicline (partial NR agonist)
  3. Buproprion (antidepressant)
25
Q

Action of b1 on kidney

A

Renin release

26
Q

a1 agonist

A

Phenylephrine

27
Q

a2 agonist

A

Clonidine

28
Q

a1 antagonist

A

Prazosin

29
Q

a2 antagonist

A

Yohimbine, Rauwolscine

30
Q

b1 agonist

A

Dobutamine

31
Q

b2 agonist

A

Salbutamol , terbutaline

32
Q

B1 antagonist

A

Metoprolol, atenolol

33
Q

B2 antagonist

A

Propranolol (non selective)

34
Q

B3 agonist

A

Mirabegron

35
Q

A2 action on platelet

A

Aggregation

36
Q

A2 on insulin release

A

Decreases insulin release

37
Q

B2 on insulin release

A

Stimulates insulin release

38
Q

S/E of nasal decongestant like naphazoline

A 
Initial stinging sensation,
Anosmia 
Impaired muco-ciliary function 
Atrophic rhinitis
Systemic s/e like cns depression, HTN
39
Q

Orally active alpha adrenergics

A

Ephedrine & Mephenteramine (resistant to mao)

40
Q

Rx amphetamine toxicity

A

Chlorpromazine

41
Q

Persistent/postural hypotension Rx

A

Adequate hydration, electrolyte balance & elastic stockings

42
Q

Non selective b blockers+ a blocking property

A

Labetelol & carvedilol

43
Q

Membrane stabilising property in

A

Propranolol, acebutolol & oxprenolol

44
Q

A/E of b blockers

A

Cns: nightmares, forgetfulness, lack of drive
CVS: bradycardia,hypotension, heart block
RS: ppt asthma bronchoconstriction
Metabolic: masking of symptoms of hypoglycaemia,dyslipidemia
BV: reduced exercise capacity, tiredness, worsening of pvd, Erectile dysfunction

45
Q

Acute glaucoma Rx

A
  1. Mannitol 20% or glycerol(10%)
  2. Acetazolamide (0.5G)
  3. Pilocarpine (1-4% every 10 minutes)
  4. Timolol 0.5%
  5. Apraclonidine/ Latanoprost may be added
46
Q

K+ blocking b blocker

A

Sotalol

47
Q

B blockers with shortest duration of action

A

Esmolol

48
Q

Intrinsic sympathomimetic activity in which b blockers

A

Pindolol, Acebutolol, Celiprolol

49
Q

Which b blockers have ccb activity

A

Carvedilol and betaxolol

50
Q

B blockers with NO release property

A

Celiprolol and nebivolol

Pharmacology (6 decks)

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