ANS 1,2,3

Question 1

Right Vagus primarily innervates?

Left Vagus primarily innervates?

Answer 1

R - SA Node

L - AV Node

Question 2

70% of blood in veins

Answer 2

regulation of venous capacity is an important determinant of the distribution of systemic blood volume

Question 3

Venous capacity

Answer 3

important regulator of cardiac output

Question 4

ACtivation of alpha receptors causes SM____ while activation of Beta receptors cause SM _____

Answer 4

COntraction
dilation
GUT as Exception

Question 5

SNS Adrenergic receptors have ___ transmembrane proteins.

So do ?

Answer 5

7

Muscarinic - PNS

Question 6

Potency of E and NE at B1 and B2

Answer 6

E is more potents than NE at B1

E in MUCH more potent that NE at B2

Question 7

SNS B1 effects:

Answer 7

SM - vasodialation ( phosphorylation of Ca-MLCK- inactivation)
Liver - glycogen breakdown
Heart - increase contractility (phosphorylation of Ca channels)

Question 8

SNS B2 effects:

Answer 8

??

Question 9

SNS alpha2 effects: ??

Answer 9

SM - vasoconstriction (dephosphorylate MLCK - inc. active-MLCK - contraction)
Auto-Inhibitory Feedback mechanism??
- NE release cause less NE release
- decrease in Ca2+ influx

Question 10

SNS alpha1 effects:

Answer 10

SM - vasoconstriction (inc Ca2+, inc active MLCK

Question 11

PNS M1 effects:

Answer 11

SM - vasodialtion
Inc Ca2+
Bladder - contraction

Question 12

PNS M2 effects:

Answer 12

Heart - Open K= Channels

Question 13

PNS M3 effects

Answer 13

Inc Ca2+

GI - contraction, inc secretion

Question 14

PNS M4 effects:

Answer 14

Dec. cAMP

Question 15

PNS M5 effects:

Answer 15

Inc Ca2+

Question 16

G protein

Answer 16

heterotrimeric

alpha, beta and gamma subunits

Question 17

Cholera toxin

Answer 17

alpha subunit G-protein
When toxin is bound to subunit, subunit cannot dissociate from adenyly cylase and the cyclase is chronically activated. pathologically elevates cAMP. Cl- and Na+ efflux. Water movement into intestinal lumen follows osmotically = diarrhea

Question 18

Cholinergic receptors - catagories, location, neurotransmmitter

Answer 18

nicotinic and muscarinic
membrane bound
ACh

Question 19

muscarinic receptor - number patterns

Answer 19

odd number - inc Ca2+

even number - dec cAMP

Question 20

How does open K+ channels slow heart rate????

Answer 20

..