anomolly

Question 1

Answer 1

alder

recessive; decreased lipid degradation; prominent dark staining granules in 1 or more cell lines; seen in Hunter’s or Hurler’s syndrome (inborn errors of metabolism

Question 2

Answer 2

Chediak-Higashi Syndrome – giant peroxidase positive lysosomal granules in cells; mucocutaneous hemorrhage from thrombocytopenia

Question 3

Answer 3

May-Hegglin Anomaly – rare autosomal dominant; patient is at risk for infections and mucocutaneous hemorrhage; large Döhle-like bodies; often includes thrombocytophenia; most patients are asymptomatic; may cause bleeding episodes

Question 4

Answer 4

Necrobiosis – dying neutrophil; only report if seen in large numbers, few are normal

Question 5

Answer 5

Nuclear Extrusion Anomaly – “drumsticks” or Barr bodies; may be inactivated X chromosome in women; increased numbers may be result of genetic defect

Question 6

Answer 6

Pelger-Huёt – hyposegmentation; autosomal dominant: bi-lobed or “pince-nez”; homozygous: no segmentation; check pt’s chart for history of disease; reporting as left shift could cause overtreatment; may have pseudo-Pelger-Huёt cells during/after chemo

Question 7

Answer 7

Twinning Anomaly – mirror image of nucleus (axial symmetry); acquired in malignancies and chemotherapy; very rare