animals models for drug development 3 Flashcards
what does brain imagine indicate for OCD
increased oribtofrontal cortex , bg, thalamus
what is the OCD circuit named
the alexander circuit
what does quinpirole do
induces compulsive checking
how does quinpirole acr
dopamine D2/D3/D4 agonist
which rats are used in quinpirole induced compulsive checking
long evans
what has a poor responder rate in QNP compulsive checking
paroxetine
what works for OCD checking
clomipramien
what is habituation
repeared exposurte to startle stimulis resulting in less response
what is PPI
attenuation of the startle stimulus
how does schizophrenia affect PPI
deficient
what is apomorphine
disrupts PPI in rodents
what is MCAO
middle cerebral artery occlusion
what drug has neuroprotective effects in mice with permanent focal brain ischemia
edaravone
what is the animal model for MS
experimental autoimmune encephalomyetis EAE
what is the cre-lox system
gene manipulation strategy that is more precise than global knockout
how do you flank the gene of interest in the cre mouse
adding loxP sites to either side
what cuts the lox P sites
cre recombinase
what drives the cre recombinase
AdVil promoter
where is AdVil expressed in
sensoty neurons of DRG
how do optogenetics work
light sensrtive algae protein inserted into DNA in neurons
what is ChR2
channel rhodopsin blue light excitayory
