animals models for drug development 3

Question 1

what does brain imagine indicate for OCD

Answer 1

increased oribtofrontal cortex , bg, thalamus

Question 2

what is the OCD circuit named

Answer 2

the alexander circuit

Question 3

what does quinpirole do

Answer 3

induces compulsive checking

Question 4

how does quinpirole acr

Answer 4

dopamine D2/D3/D4 agonist

Question 5

which rats are used in quinpirole induced compulsive checking

Answer 5

long evans

Question 6

what has a poor responder rate in QNP compulsive checking

Answer 6

paroxetine

Question 7

what works for OCD checking

Answer 7

clomipramien

Question 8

what is habituation

Answer 8

repeared exposurte to startle stimulis resulting in less response

Question 9

what is PPI

Answer 9

attenuation of the startle stimulus

Question 10

how does schizophrenia affect PPI

Answer 10

deficient

Question 11

what is apomorphine

Answer 11

disrupts PPI in rodents

Question 12

what is MCAO

Answer 12

middle cerebral artery occlusion

Question 13

what drug has neuroprotective effects in mice with permanent focal brain ischemia

Answer 13

edaravone

Question 14

what is the animal model for MS

Answer 14

experimental autoimmune encephalomyetis EAE

Question 15

what is the cre-lox system

Answer 15

gene manipulation strategy that is more precise than global knockout

Question 16

how do you flank the gene of interest in the cre mouse

Answer 16

adding loxP sites to either side

Question 17

what cuts the lox P sites

Answer 17

cre recombinase

Question 18

what drives the cre recombinase

Answer 18

AdVil promoter

Question 19

where is AdVil expressed in

Answer 19

sensoty neurons of DRG

Question 20

how do optogenetics work

Answer 20

light sensrtive algae protein inserted into DNA in neurons

Question 21

what is ChR2

Answer 21

channel rhodopsin blue light excitayory