animals models for drug development 2

Question 1

what 2 types of drugs restore/ reverse behaviours in young monkeys separated from their mothers

Answer 1

tricyclic antidepressants and ECS

Question 2

what neuroleptic is ineffective at treating young monkey behaviours

Answer 2

chlorpromazine

Question 3

what drugs show function in the Porsolt forced swim test

Answer 3

antidepressants and Buspirone

Question 4

what is the occasional antidepressant exception in the Porsolt forced swim test

Answer 4

SSRIs

Question 5

which drug increases swimming in mice in the Porsolt forced swim test

Answer 5

fluoxetine (prozac)

Question 6

which drug increases climbing in mice in the prosolt forced swim test

Answer 6

reboxetine

Question 7

what kind of drug is flueoxetine

Answer 7

SSRI

Question 8

what kind of drug is reboxetine

Answer 8

NRI

Question 9

what is the tail suspension test used to measure

Answer 9

antidepressants

Question 10

what kind of model is the elevated plus maze for

Answer 10

anxiety

Question 11

where would mice rather spend time

Answer 11

closed arms

Question 12

what is lorarepam

Answer 12

benzodiazepine (anti-anxiety)

Question 13

what is yohimbine

Answer 13

alpha 2 adrenergic antagonist (increases anxiety)

Question 14

what kind of test in the vogel conflict test useful for

Answer 14

anxiety

Question 15

how does the vogel conflict test work

Answer 15

punish water drinkinh

Question 16

what is the defensive burying test useful for

Answer 16

defensive burying

Question 17

what is the Y-maze test useful for

Answer 17

learning and cognition

Question 18

what lesions is the Y-maze test sensitive to

Answer 18

hippocampal lesions

Question 19

what is the morris water maze test useful for

Answer 19

learning and cognition

Question 20

what lesions will not impair morris water maze performance

Answer 20

cortical

Question 21

what drugs are known to affect learning and memory in humans

Answer 21

scopolamine and benzodiazepines

Question 22

what drugs may help with morris water maze performance

Answer 22

cholinesterase inhbiithots

Question 23

what are the two cholineesterase inhibitors of interest

Answer 23

donezipil and rivastigmine

Question 24

why do cholinesterases assist with memory

Answer 24

prevent breakdown of ACh

Question 25

what is memantine

Answer 25

regulates glutamate activity, imporives memory `

Question 26

what is the radial arm maze test

Answer 26

8 arms with 4 blocked`

Question 27

what is a working error in the radial arm maze test

Answer 27

re-entry of an arm that has been baited

Question 28

what is a reference memory error

Answer 28

entry that has been baited in training but not in test

Question 29

what is the social interaction test useful for

Answer 29

learning andf cognition

Question 30

what does CRF do

Answer 30

anxiogeninc