animals models for drug development 2 Flashcards
what 2 types of drugs restore/ reverse behaviours in young monkeys separated from their mothers
tricyclic antidepressants and ECS
what neuroleptic is ineffective at treating young monkey behaviours
chlorpromazine
what drugs show function in the Porsolt forced swim test
antidepressants and Buspirone
what is the occasional antidepressant exception in the Porsolt forced swim test
SSRIs
which drug increases swimming in mice in the Porsolt forced swim test
fluoxetine (prozac)
which drug increases climbing in mice in the prosolt forced swim test
reboxetine
what kind of drug is flueoxetine
SSRI
what kind of drug is reboxetine
NRI
what is the tail suspension test used to measure
antidepressants
what kind of model is the elevated plus maze for
anxiety
where would mice rather spend time
closed arms
what is lorarepam
benzodiazepine (anti-anxiety)
what is yohimbine
alpha 2 adrenergic antagonist (increases anxiety)
what kind of test in the vogel conflict test useful for
anxiety
how does the vogel conflict test work
punish water drinkinh
what is the defensive burying test useful for
defensive burying
what is the Y-maze test useful for
learning and cognition
what lesions is the Y-maze test sensitive to
hippocampal lesions
what is the morris water maze test useful for
learning and cognition
what lesions will not impair morris water maze performance
cortical
what drugs are known to affect learning and memory in humans
scopolamine and benzodiazepines
what drugs may help with morris water maze performance
cholinesterase inhbiithots
what are the two cholineesterase inhibitors of interest
donezipil and rivastigmine
why do cholinesterases assist with memory
prevent breakdown of ACh
what is memantine
regulates glutamate activity, imporives memory `
what is the radial arm maze test
8 arms with 4 blocked`
what is a working error in the radial arm maze test
re-entry of an arm that has been baited
what is a reference memory error
entry that has been baited in training but not in test
what is the social interaction test useful for
learning andf cognition
what does CRF do
anxiogeninc
