Angiotensin II Recptor Blockers

Question 1

Angiotensin II Receptor Blockers Drug Names

Answer 1

Candesartan 
Irbesartan
Losartan 
Olmesartan 
Telmisartan 
Valsartan 

“-startan”

Question 2

Angiotensin II Receptor Blockers Therapeutic Actions

Answer 2

• Angiotensin II receptor agonist
• Blocks angiotensin II from binding with on the receptors on the vascular smooth muscle and in the adrenal cortex
- Prevents vasoconstriction
- Prevents release of aldosterone (sodium and water excreted)

Question 3

Angiotensin II Receptor Blockers Indications

Answer 3

• HTN
• CHF
• Diabetic nephropathy

Question 4

Angiotensin II Receptor Blockers Contraindications and Cautions

Answer 4

Contraindication:
• Allergy
• Pregnancy- black box warning

Caution:
• Hepatic dysfunction
• Renal dysfunction
• Hypovolemia (liquid portion of blood is too low)

Question 5

Angiotensin II Receptor Blockers DDI

Answer 5

• Other drugs affecting RAAS

* NSAIDs

Question 6

Angiotensin II Receptor Blockers Adverse Effects

Answer 6

• CNS: HA, dizziness, syncope, weakness
• CV: hypotension
• GI complaints
• Skin: rash
• Hyperkalemia
• Renal damage

Question 7

Angiotensin II Receptor Blockers:

Assessment

Answer 7

Hx: allergy, contra/cautions, pregnancy, liver impairment
Physical: vital signs, weight, cardiac respiratory, abdominal, skin (baseline)
Labs: renal functions, electrolytes, pregnancy test, liver function

Question 8

Angiotensin II Receptor Blockers:

Diagnosis

Answer 8

• Ineffective tissue perfusion
• Impaired skin integrity
• Acute pain
• Deficient knowledge

Question 9

Angiotensin II Receptor Blockers:

Implications

Answer 9

• Encourage lifestyle changes
• Can take with or without food, if GI effects give with food
• Use of barrier contraceptives
• Monitor the patient carefully in any situation that might lead to a drop in fluid volume
• Provide throughout patient teaching

Question 10

Angiotensin II Receptor Blockers: Evaluation

Answer 10

Response to the drug (weight, electrolytes, blood pressure, EKG)

Adverse effects (hypotension, fatigue, dry cough, hyperkalemia, reflex tachycardia)

Effectiveness of comfort measures Compliance with the regimen

Effectiveness of the teaching plan