Angiotensin II Receptor Blockers (ARBs) Flashcards
1
Q
Commonly used drugs
A
Candesartan
Losartan
Irbesartan
-sartan
2
Q
What are they used for?
A
HTN (addition/instead of ACEi)
Use if ACEi causes cough
Post-MI
Diabetic nephropathy
3
Q
How do they work?
A
Selectively inhibit angiotensin II at AT1 receptor site
Binding of angiotensin at AT1 receptor causes vasoconstriction, release of aldosterone, other harmful CV effects
Therefore, ARBs cause vasodilation and blockage of aldosterone release = decrease BP
4
Q
Contraindications
A
Aliskrien
Aortic/mitral stenosis
Elderly
Hypertrophic cardiomyopathy
Renal artery stenosis
5
Q
Interactions
A
ACEi - risk of AKI, hyperkalaemia Aliskrien Ciclosporin Diuretics K+ sparing diuretics Lithium
6
Q
Side effects
A
Dizziness
Headache
Fatigue
Check kidney function
