Angiogenesis Quiz Flashcards

1
Q

Fill in the gaps:

Blood vessel growth is induced by production of __1__, discovered by Napoleone Ferrara in 1989, which is the same protein a VPF discovered by __2__’s group.

A

1: VEGF
2: Hal Dvorak’s

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2
Q

Fill in the gaps:

VEGF acts on __1__ to induce increased intracellular __2__, release of __3__, __4__ withdrawal, and endothelial __5__.

A

1: VEGFR2
2: calcium
3: proteases
4: pericyte
5: migration

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3
Q

Hypoxia increases VEGF protein by….

A

Increasing VEGF mRNA expression

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4
Q

Place the processes in the right order:

Sprout fusion
increased intracellular calcium
hypoxia
VEGF production
matrix metalloproteinase production
increased vascular permeability
VEGFR2 activation
sprouting
migration
proliferation
A
  1. Hypoxia
  2. VEGF production
  3. VEGFR2 activation
  4. Increased intracellular calcium
  5. Increased vascular permeability
  6. Matrix metalloproteinase production
  7. Sprouting
  8. Migration
  9. Proliferation
  10. Sprout fusion
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5
Q

Which of the following statements are true?

A) Ramucirumab is an antibody to VEGFR
B) Anti-VEGF antibodies are more effective when combined with chemotherapy than by themselves
C) Bevacizumab is a monoclonal antibody to VEGF-A
D) VEGF inhibitors are equally ineffective in all cancers
E) Pazopanib is a VEGFR tyrosine kinase inhibitor

A

A, B, C, and E are all true

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