Angiogenesis Quiz Flashcards
Fill in the gaps:
Blood vessel growth is induced by production of __1__, discovered by Napoleone Ferrara in 1989, which is the same protein a VPF discovered by __2__’s group.
1: VEGF
2: Hal Dvorak’s
Fill in the gaps:
VEGF acts on __1__ to induce increased intracellular __2__, release of __3__, __4__ withdrawal, and endothelial __5__.
1: VEGFR2
2: calcium
3: proteases
4: pericyte
5: migration
Hypoxia increases VEGF protein by….
Increasing VEGF mRNA expression
Place the processes in the right order:
Sprout fusion increased intracellular calcium hypoxia VEGF production matrix metalloproteinase production increased vascular permeability VEGFR2 activation sprouting migration proliferation
- Hypoxia
- VEGF production
- VEGFR2 activation
- Increased intracellular calcium
- Increased vascular permeability
- Matrix metalloproteinase production
- Sprouting
- Migration
- Proliferation
- Sprout fusion
Which of the following statements are true?
A) Ramucirumab is an antibody to VEGFR
B) Anti-VEGF antibodies are more effective when combined with chemotherapy than by themselves
C) Bevacizumab is a monoclonal antibody to VEGF-A
D) VEGF inhibitors are equally ineffective in all cancers
E) Pazopanib is a VEGFR tyrosine kinase inhibitor
A, B, C, and E are all true