angiogenesis 2

Question 1

The angiogenic factors in a tissue reflects … (cancer related)

Answer 1

the aggressiveness with which tumor cells spread

Question 2

Simple words , how does ANTIangionic therapy treat cancer?

Answer 2

Limit their blood supply to shrink the tumours and prevent it from growing

Question 3

what are the 5 classes of angiogenic antagonists in trials?

Answer 3

inhibitors of proteases (inhibit the synthesis of MMP);

Inhibitors of endothelial cell migration and proliferation; VEGR signalling

Inhibitors of angiogenic growth factors; VEGF,EGFR & HER2

Inhibitors of matrix proteins on the endothelial cell surface such as integrins, copper;

inhibitors with unique mechanisms (thalidomide and lenalidomide

Question 4

what are the two type of anti-VEGF signalling?

Answer 4

monoclonal antibodies (targets specific GF aka VEGF)

small molecule tyrosine kinase inhibitors (TKIs) ( targets multiple Gf and soecifically the receptor)

Question 5

What are the important FDA approved anti-angiogenic drugs?

Answer 5

Bevaciz-umab(cervical/ovarian cancer)
ramucri-uamb (gastro-oesophageal cancer, colon rectal)
sorafeinb (thyroid cancer)
sunitinib( pancreatic cancer)

Question 6

Vascular Endothelial Growth Factor (VEGF) Binds to the VEGF Receptor (VEGFR), a Receptor Tyrosine Kinase, Leading to Receptor Dimerization and Subsequent Auto Phosphorylation of the Receptor Complex

what does dimerisation mean?

Answer 6

he chemical reaction that joins two molecular subunits, resulting in the formation of a single dimer.