Anesthesia

Question 1

How is pharmokinetics defined? What are the factors that influence pharmokinetics?

Answer 1

It describes what the body does to a drug. Absorption, distribution, metabolism and excretion are the factors that influences the pharmokinetics of a drug

Question 2

Termination of a drug’s effects occurs by?

Answer 2

Metabolism, excretion, redistribution (distribution?)

Question 3

Define absorption

Answer 3

the rate at which a drug leaves its site of administration

Question 4

the rate at which a drug leaves its site of administration describes what process of pharmokinetics?

Answer 4

Absorption

Question 5

What are factors that affect absorption?

Answer 5

Liquids/crystalloids > solids/colloids
High lipid solubility favors easy passage of drugs through membranes
High surface area, local blood supply, heat/vasodilation increases absorption
Cold/vasoconstriction decreases drug absorption
pH
pKa of drug
Degree of ionization vs non-ionization of drug
Protein binding
Molecular weight

Question 6

Define distribution

Answer 6

the transfer of a drug from one location to another

Question 7

The transfer of a drug from one location to another describes what process of pharmokinetics?

Answer 7

Distribution