Anemias Flashcards
Pancytopenia
Decrease in all blood cell types. “Pan” meaning many, “cyto” meaning cell, “penia”meaning decreased
What do you think the value for MCV will be in a macrocytic normochromic type of anemia?
MCV>100
Microspherocyte
Smaller than normal RBC that is hyperchromic. Stains more densely and no central pallor
Hypersegmented neutrophil
Segmented neutrophils that has a nucleus with five or more lobes
Parietal cell
A large so on the margin of the gastric glands of the stomach secretes hydrochloric acid and intrinsic factor
Ileum
The lower 3/5 of the small intestine
What is anemia
The result of either decreased RBC production or increase decreased RBC destruction
Classify three types of anemia
Macrocytic/Normochromic
Microcytic/hypochromic
Normocytic/normochromic
What is Thalassemia?
A genetically transmitted type of hemolytic anemia caused by a decrease rate of synthesis of one of the polypeptide chains of hgb
What is anemia
A increase in RBC destruction or loss
What is Hgb S
Hemoglobinpathy that has amino acid substitution of VALINE for glutamic acid in the 6th position of the beta chain.
Characteristics of Sickle Cell
Moderate poik, sickle cell, target cells, Howell jolly bodies, polychromasia, few nRBC’s
Characteristics of Hgb H global chain
4 betas
Sickle cell anemia is represented by what types of hgb?
SS
What type of anemia is sickle cell?
Normocytic/normochromic
What type of anemia is Aplastic anemic?
Normocytic/ normochromic
Treatment for folate deficiency?
Folic acid
What type of anemia is Megaloblastic Anemia?
Macrocytic/normochromic
What are the types of Megaloblastic anemia?
Vitb12 deficiency and folate deficiency
Causes of vib12 deficiency
Pernicious anemia
Gastrectomy
Diphyllobothrium latum
Dietary deficiency
What is pernicious anemia?
Lack of vitb12 absorption due to the lack of intrinsic factor .
What is intrinsic factor?
Transport protein which is produced by gastric parietal cells
Causes of folate deficiency
Poor diet , increased need(I.e. Pregnancy), chronic hemolysis, non Megaloblastic anemia
Parietal cell
A large cell on the margin of gastric glands of the stomach that secretes hydrochloric acid
