Anemia Feripriva Flashcards

1
Q

MCV - femtolitru (fl) volumul mediu cirpuscular al gl rosii valoare la nastere, 3luni-2 luni 5 ani ;adult

A

valoare la nastere 120fl
3luni-2 ani 80-85
5 ani 85
;adult 90

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2
Q

GR gl rosii(10 la a 6/mm3)

A

valoare la nastere, 5.5
3luni-2 ani 3.5-4.5
5 ani 4.5-5
;adult 5

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3
Q

Hg(g%)

A

valoare la nastere 18
3luni-2 ani 11-12
5 ani 13
;adult 15

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4
Q

G A (/mm3)

A

valoare la nastere, 10-25.000
3luni-2 ani 10.000
5 ani 8000
;adult 8000

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5
Q

PMN%

A

valoare la nastere, 60
3luni-2 ani 30
5 ani 45
;adult 60

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6
Q

Eozinofile%

A

valoare la nastere,
3luni-2 ani
5 ani —- toate 2-3
;adult

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7
Q

Bazofile%

A

valoare la nastere,
3luni-2 ani
5 ani -toate <0.5
;adult

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8
Q

Limfocite%

A

valoare la nastere, 30
3luni-2 ani 60
5 ani 45
;adult 30-35

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9
Q

Monocite%

A

valoare la nastere, 8
3luni-2 ani 6
5 ani 5
;adult 5

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10
Q

Trombocite(/mm3)

A

valoare la nastere, 100-300.000
3luni-2 ani 150-450.000 la fel
5 ani 150-450.000
;adult150-450.000

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11
Q

Ht% patologice pt anemie

A
Prima zi de viata 44-47
2-6luni          32  42
6L-5ani          33
5-11ani          34
12-13 ani        36
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12
Q

VEM volum mediu eritr val normala

A

90 microni cubi

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13
Q

HEM

A

32 pg

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14
Q

CHEM cantit eritr medie pe hemogl

A

32-36g/dl

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15
Q

Calsificarea anemiilor
A anemii microcitate hipocrome
Cauze

A

A . CHEM<33%
VEM<80 fl
●cu deficit de sinteza a hemului
1 carenta nutritionala /pierderi cronice
2A hipocrome hiposideremice din boli inflam
3 A sideroblastice(ereditare -piridoxino sensibile/rezitente)(dobandite-medicam toxic,boli inflam neoplazice)
●cu decidit sinteza globinei
Srd talasemice
Homoglobinopatii de tip talasemic

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16
Q

B.A macrocitare

A

VEM>80-100fl
Cu megalobrastoza medulara(deficit acid folic,def B12)
Fara megalobrast med

17
Q

C. A normocrome normocitare

A
VEM=80fl
CHEM=33%
Care sunt 
regenerative!! Reticulocite>15-20%.la mie 
Hiporegenerative retic<15-20la mie
18
Q

Amenia feripriva
Capitalul total de fier=75mg/kgc
Cauze frecvente

A

Carentiale de aport
Insuf rezervelor
Pierderile(frecv hemoragii mici repetate ,cronice)
Consumul crescut(infectii cronice)-TBC boli infl hemosideroza
Necesitati crescute(prematur sugar prepubertate si postpubert
Insufivienta transportului rar

19
Q

Cauze a prin carenta de fier

A

•Aportul deficitar
Alim artificiala cu lapte de vaca
Diversificare tardiva si sua incorecta predom cu prep fainoase
Regim vegetarian

• insuficienta rezervelor la nastere
Prematuritate
Transfuzie feto fetala
Melena intrauterina
Ligatura precoce a cordonului ombilic
20
Q

Tulburari de absortie a feripriva

A
Globala..
Aclorhidie
Gastrita atrofica
 Celiakie
Mucoviscidoza
Intoleranta la dizaharide

Selectiva…
Malabsortie selectiva pt fier Riley

21
Q

Pierderi d fier

A

Sange
Exudatie proteica nfrotic
Descuamatie celulara:psoriazis
Fier pierd intest

22
Q

Necesar de Fe zilnic

A

8-10mg

23
Q

Examinari A feripriva

A

1 etapa:
Microcitoza adaptativa (<70fl 6L-12ani
<73fl 2-5ani
<80 >12ani ANEMIA SI HIPOC4OMIA ABSENTE

2 etapa:
scaderea concentr de Hb cu hipocromie concomitenta
HEM<27pg
CHEM<30%
Afectare nr de hematii lipseste
•uneori scade si nr eritrocite

SIDEREMIA N.=80-120gama% se renunta pt
FEP protoporfirina eritrocit libera si
Feritinei dg+si dif

24
Q

A feripriva clasif dupa Hb

A

Hb 9-10gr% usoara
Hb 8.9-7gr% medie
Hb<7gr% severa

25
Q
A.FER valoare normala
B.Coeficentul de saturare a siderofilinei(Transferinei)
C transferina
D.capacit totala de fixare a fierului
E.feritina serica
A

VN=15.5+-8.3mg% limita sup 40mg%
Penultimul stadiu in biositenta fierului
●FER creste cand– scad depozitele de Fe inainte de instalare A. Microcitare(indiciu pt terapia cu Fe)
Valori crescute ale FER: intox cu plumb,infectii cronice anemii sideroblastice

B. Normal30% in a feripr scazut<16%
C.VN 200-400mg%
D.VN 250-400gama% in A fer creste>400
E. Indica valoare de fe din depozit
VN=30-142ng/ml
In Af scade sub 10ng/ml
!!!!!!f importanta in dg dif normala talasemie
Crescuta inflam cr infevtii b maligne
Valoare de 15ng/ml CONFIRMA DG  DE DEFICIT DE FE!!
26
Q

Profilax antenatala

A

Daca Hb<11g/dl adm oral in ultimul trimestru de sarcina adm oral zilnic
Fe 60-100mg +acid folic

27
Q

Profilax postnatala

A

Legrea cordonului ombilicar tardiv dupa disparitia pulsatiilor .alim la san.alim diversifuc corsp

28
Q

Profilax medicam sulfat feros

A

Oral
Prematuri gemeni-vr 6-8sapt doza 1-2mg/kg/zi pana la 1 an
Sugar la termen nascut la vr 6Luni aceeasi doza cel putin 3 luni
Fe din laptele uman absorbit mai rapiddd fara de cel din lapt d vaca dat continut de calciu

29
Q

Trat medicamentos a feripr

A

Doza 5-6mg/kg/zi oral in 3 prize

Criza reticulocitara dupa 5..10 zile
Apoi Hb normala dupa 3 sapt
2..3 luni refacerea rezerv de fier

30
Q

Preparate de fier solubile

A

Sulfat feros Fereogradumet tb102mg fe
Fumarat deros Ferronat 50mg/5ml
Glutamat feros Glubifer 22mg fe tb
Gluconat feros Sirofer 25mg fe/5 ml

31
Q

Transfuzia cu masa eritrocitara izo grup izo rh indicatie

A

Cand Hb<7g/dl