Anemia Due To Underproduction

Question 1

How do we characterize anemia due to underproduction?

Answer 1

Decreased production of RBCs by the bone marrow and there is a corrected low reticulocyte count.

Question 2

3 major etiologies of underproduction?

Answer 2

Anything causing micro or macrocytic anemia
Renal failure because low EPO
Damage to bone marrow precursor cells

Question 3

How does Parvovirus b19 cause underproduction anemia?

Answer 3

Infects progenitor RBCs and temporarily stops productions of RBCs. This is especially intense anemia when you have a preexisting condition with no real reserve.

Question 4

What is going on with anaplastic anemia? What 3 things can cause it? What does biopsy show of the bone marrow?

Answer 4

Damage to the HSC resulting in pancytopenia.
Drugs/chemical, viral infections, and autoimmune
Empty fatty marrow

Question 5

How do we best define myelophthisic process?

Answer 5

Pathologic process, like metastatic cancer, that replaces bone marrow so blood production is impaired and there is pancytopenia.