Anemia Flashcards
Identify function of erythropoietin – what does it do, where is it produced & what stimulates its production
What:
Where:
How:
Identify the laboratory test that provides an index of the erythropoietic action of the bone marrow
Differentiate between adult and fetal hgb
Adult
Fetal
Define anemia and associated values
A megaloblastic anemia caused by gastritis with decreased production of intrinsic factor; accompanied by neurologic changes:
B-12
A megaloblastic anemia associated with malnutrition, for example, in elderly people or people with alcoholism; not accompanied by neurologic changes:
Folic Acid Deficiency
A cause of acute anemia with risk of hypovolemic shock; cells are of normal size and color:
Hemorrhagic anemia
Accompanies gastric irritation associated with chronic aspirin use for control of arthritis pain:
Iron deficiency
End-stage renal failure, AIDS, or cancer are most likely causes of:
Chronic disease anemia
RBCs are injured and destroyed, for example by transfusion reactions, toxins, venoms, malaria, or by mechanical injury with burns or heart valve defects; RBCs are normal size and color:
Hemolytic
Signs and symptoms include increased risk of bleeding, infections, and fatigue:
Aplastic
Hereditary anemia affecting blacks; hemoglobin HbS causes abnormally shaped RBCs, which lead to hypoxia:
Sickle Cell
Hereditary anemia in various racial and ethnic groups; errors occur in synthesis of hemoglobin chains; children with disorder may have severe growth retardation:
thalasemmia
An autosomal dominant disorder in which RBCs form tight spheres that are easily destroyed in vessels of the spleen; may be treated by splenectomy:
spherocytosis
Macrocytic-normochromic eteology
Vitamin B-12
Folic acid
Microcytic-hypochromic eteology
Iron deficiency
Decreased heme synthesis
Discuss the “common or classic “ clinical manifestations of anemia and the pathogenesis behind them
Discuss clinical manifestations seen with the hemolytic anemias
Discuss clinical manifestations seen with the aplastic anemias
B-12 deficiency:
Etiology
B-12 deficiency:
pathogenesis
B-12 deficiency:
Manifestations
Folic acid deficiency:
eteology
Folic acid deficiency:
pathogenesis
Folic acid deficiency:
Manifestations
Identify the major causes of hemolytic anemias
Identify the factors that can precipitate sickle cell crisis
Identify the hemolysis seen in G6PD anemia
Define polycythemia
What is relative polycythemia?
Give examples
What is Primary polycythemia?
Give examples
What is seconday polycythemia?
Give examples
Discuss the pathogenesis behind the clinical manifestations seen in primary polycythemia (polycythemia vera)
