Anemia Flashcards

1
Q

the major hemoglobin in post natal life is?

A

HbF (fetal hemoglobin which contains alpha2/gamma2 subunits)

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2
Q

beta thalassemia major symptoms occur when

A

around 6 months when fetal hemoglobin turns to adult hemoglobin (HbA , which has subnits of alpha2/beta2)

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3
Q

symptoms of b thalassemia

A

microcytic anemia, slowed growth, pallor, hepatomegaly, splenomegaly

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4
Q

B thalassemia minor vs. Beta thalassemia major : pathophysiology

A

minor: decreased production of B globin chain

major: absent B globin chain

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5
Q

B thalassemia minor vs. Beta thalassemia major : Symptoms

A

minor: asymptomatic microcytic anemia

severe: severe microcytic anemia after 6 months of life, bone marrow expansion with chipmunk facies, extra-medullary hematopoiesis and hepatosplenomegaly, increase risk of aplastic crisis with infection of parvovirus B19.

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6
Q

B thalassemia minor vs. Beta thalassemia major : diagnostic findings

A

minor: hemoglobin A2>3.5%

major: target cells, increased fetal hemoglobin, increased hemoglobin A2

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7
Q

iron deficiency anemia labs

mcv:
serum iron:
serum ferritin:
total iron binding capacity:

A

mcv: microcytic <80
serum iron: low
serum ferritin: low
total iron binding capacity: increased

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8
Q

B thalassemia intermedia
B thalassemia major

A

intermedia: decreased Hemoglobin A2 (alpha and beta subuinit) leading to increased hemoglobin F (alpha and gamma) with the presence of a microcytic anemia - treatment is supportive

major: both beta alleles are gone and leads to tranfusion dependent anemia, extramedullary hematopoiesis (frontal bossing)

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9
Q

sickle cell disease hemoglobin electrophoresis

A

increased hemoglobin F and hemoglobin S

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