Anemia Flashcards
the major hemoglobin in post natal life is?
HbF (fetal hemoglobin which contains alpha2/gamma2 subunits)
beta thalassemia major symptoms occur when
around 6 months when fetal hemoglobin turns to adult hemoglobin (HbA , which has subnits of alpha2/beta2)
symptoms of b thalassemia
microcytic anemia, slowed growth, pallor, hepatomegaly, splenomegaly
B thalassemia minor vs. Beta thalassemia major : pathophysiology
minor: decreased production of B globin chain
major: absent B globin chain
B thalassemia minor vs. Beta thalassemia major : Symptoms
minor: asymptomatic microcytic anemia
severe: severe microcytic anemia after 6 months of life, bone marrow expansion with chipmunk facies, extra-medullary hematopoiesis and hepatosplenomegaly, increase risk of aplastic crisis with infection of parvovirus B19.
B thalassemia minor vs. Beta thalassemia major : diagnostic findings
minor: hemoglobin A2>3.5%
major: target cells, increased fetal hemoglobin, increased hemoglobin A2
iron deficiency anemia labs
mcv:
serum iron:
serum ferritin:
total iron binding capacity:
mcv: microcytic <80
serum iron: low
serum ferritin: low
total iron binding capacity: increased
B thalassemia intermedia
B thalassemia major
intermedia: decreased Hemoglobin A2 (alpha and beta subuinit) leading to increased hemoglobin F (alpha and gamma) with the presence of a microcytic anemia - treatment is supportive
major: both beta alleles are gone and leads to tranfusion dependent anemia, extramedullary hematopoiesis (frontal bossing)
sickle cell disease hemoglobin electrophoresis
increased hemoglobin F and hemoglobin S