Anatomy & Physiology Flashcards
What changes are made to the following in Cushings Syndrome:
- BP
- fluid volume
- weight
- BGL
- Sodium
- Water
- Potassium
Elevated
- BP
- Fluid volume
- Weight
- BGL
- Sodium
- Water
Reduced
- Potassium
What changes are made to the following in Addison’s disease:
- BP
- Fluid volume
- weight
- BGL
- Sodium
- Water
- Potassium
Reduced
- BP
- Fluid volume
- weight
- BGL
- sodium
- water
Elevated
- Potassium
What is the normal range for sodium and its physiology?
Range
135 - 145
- Helps maintain blood volume and blood pressure
- Sodium causes the body to retain water
- Brain - imbalances can lead to neuro changes
Name the function and normal range of potassium K+
Normal range
3.5 - 5 mEq/L
- helps muscles to contract
- Think heart muscle - imbalances can cause cardiac dysrhythmias that can be life-threatening
What is the normal range and function of calcium Ca+?
Range
9 - 11 mg/dL
- helps with heart function, blood clotting and bone formation
- Think bones - imbalances can lead to an increase in fractures
What is the normal range and function of magnesium mg?
Range
1.5 - 2.5
- Helps muscles and nerves to stay healthy
- helps to regulate energy levels
- think calm and sedated - it acts like a sedative
What is the normal range and function of phosphorus P?
Range
2.5 - 4.5
- helps create and maintain teeth and bones
- helps to repair cells and body tissues
- think teeth - helps the body use vitamins to maintain tooth and bone health
Name the function and normal values of chloride Cl
Range
95 - 105 mEq/L
- helps maintain acid-base balance
- helps to control fluid levels in the cells
What is Hypernatremia, including:
- signs and symptoms
- possible causes
- treatment
Hypernatremia is an imbalance of sodium
Signs and symptoms
Na+ > 145 mEq/L
- flushed skin, restlessness, anxiety, confusion, irritability, increased BP, pitting oedema, reduced urine output, dry skin, agitation, low-grade fever, thirst
possible causes
- increased sodium intake
- loss of fluids ie. burns, fever
Treatment
- Restrict sodium intake
- administer isotonic or hypotonic solutions
What are the two types of hyponatremia and what are they caused by?
Na+ < 135 mEq/L
Hypovolemic
- reduced levels of fluid and sodium
- body loses too much fluid ie. blood or water
Hypervolemic
- increased levels of water in the body which dilutes sodium
- too much fluid in the body
Explain the following about Hyponatremia
- signs and symptoms
- possible causes
- treatment
Na+ < 135 mEq/L
Signs and symptoms
- Stupor/coma
- Anorexia
- nausea, vomiting
- lethargy
- tachycardia
- muscle weakness
- orthostatic hypotension
- seizures or headache
- stomach cramping
possible causes
- Loss of sodium from diaphoresis, vomiting, drains, diuretics
- Increased water and reduced sodium can lead to heart failure
Treatment
- IV hypotonic solutions
- fluid restrictions
Explain the following about Hyperkalemia
- Signs and symptoms
- possible causes
- treatment
Potassium K+ imbalance
> 5 mEq/L
Signs and symptoms
- Muscle cramps and weakness
- urine abnormalities
- Respiratory distress
- Reduced cardiac contractility
- Reduced HR and BP
- ECG changes (peaked T wave)
- Reduced reflexes
Possible causes
- Increased potassium intake
- Adrenal gland issues
- increased acid in the blood
- NSAIDs
- Potassium-sparing diuretics (spironolactone)
Treatment
- Stop potassium intake
- administer IV sodium bicarbonate
- IV calcium gluconate
- ECG
Explain the following about Hypokalemia
- Signs and symptoms
- possible causes
- treatment
Potassium K+ Imbalances
< 3.5 mEq/L
Signs and symptoms
- generalised weakness
- reduced reflexes
- shallow breathing
- slow GI system (constipation)
- reduced BP
- nausea and vomiting
- ECG Changes (flat T wave)
Possible causes
- Low potassium intake
- vomiting and diarrhea
- gastric suction
- alkalosis
- potassium-wasting diuretics (loop or thiazide)
Treatment
Replace the potassium
- oral supplements
- IV potassium (diluted) - infuse slowly
- ECG
Explain the following about Hypercalcemia
- Signs and symptoms
- possible causes
- treatment
Calcium Ca+ imbalances
> 11 mg/dL
Sign and symptoms
- bone pain
- arrhythmias
- cardiac arrest (bounding pulse)
- kidney stones
- muscle weakness
- excessive urination
Possible causes
- Increased calcium absorption
- Reduced calcium excretion
- kidney disease
- thiazide diuretics
- hyperparathyroidism
- hyperthyroidism
- bone breakdown from metastatic cancer
- Increased blood concentration
Treatment
- Stop Ca+ intake
- Administer Ca+ reducing meds (phosphorus and calcitonin)
Explain the following about Hypocalcemia
- Signs and symptoms
- possible causes
- treatment
Calcium Ca+ imbalances
< 9 mg/dL
Signs and symptoms
- Convulsions
- seizures
- cardiac arrhythmias
- tetany (involuntary muscle contractions)
- Spasms
- stridor
- numbness in fingers, face and limbs
Possible causes
- issues absorbing calcium from GI tract
- too much calcium leaving the body through excretion
- kidney disease
- diuretics
- diarrhea
- drains
Treatment
- increase calcium intake
- supplements (Vitamin D, Calcium gluconate)
- seizure precautions
Explain the following about Hypermagnesemia
- Signs and symptoms
- possible causes
- treatment
Magnesium Mg imbalance > 2.5 mg/dL
Signs and symptoms
- reduced deep tendon reflexes
- lethargy
- Reduced HR, BP, RR, bowel sounds
- Shallow breathing
Possible causes
- Increased magnesium intake
- antacids
- Excessive IV magnesium administration
- Renal insufficiency
- reduced excretion increasing levels in the blood
- diabetic ketoacidosis (DKA)
Treatment
- Administration of loop diuretics
- reduced magnesium in the diet
- IV calcium chloride or calcium gluconate
- avoid laxatives and antacids containing Mg
Explain the following about Hypomagnesemia
- Signs and symptoms
- possible causes
- treatment
Magnesium Mg Imbalances < 1.5 mg/dL
Signs and symptoms
- Increased deep tendon reflexes
- Increased HR, BP
- Shallow respirations
- Twitches
- seizures
- irritability
- confusion
Possible causes
- Insufficient Mg intake
- Malnutrition
- Vomiting, diarrhea
- malabsorption syndrome
- chrones or celiac
- Increased Mg excretion (diuretics)
- Alcoholism
- sepsis
- hyperglycemia
- Insulin administration
Treatment
- Administration of IV or PO magnesium sulfate
- Increased intake of Mg containing foods
- seizure precautions
Explain the following about Hypophosphatemia
- Signs and symptoms
- possible causes
- treatment
Phosphorus P imbalances < 2.5mg/dL
Signs and symptoms
- fatigue
- weakness
- delayed growth in kids
- poor bone density
- frequent fractures
- loss of appetite
- cardiac arrhythmias
Possible causes
- Chronic vomiting or diarrhea
- over-consumption of diuretics
- significant burns
- ETOH dependency
- Malnutrition
- Starvation refeeding syndrome
Treatment
- Increase phosphorus in diet
- administer IV or PO phosphorus
- reduce use of diuretics
- Reintroduce nutrients slowly
- proper care of burns
Explain the following about Hyperphosphatemia
- Signs and symptoms
- possible causes
- treatment
Phosphorus P imbalances > 4.5 mg/dL
Signs and symptoms
- directly leads to low Ca+ levels
- muscle spasms
- tetany
- cardiac arrhythmias
- seizures
- dry brittle skin and nails
Possible causes
- Kidney dysfunction
- consistent use of enemas or laxatives
- Vit D toxicity
- Hypoparathyroidism
- Acromegaly (pituitary gland produces too much growth hormone)
- Rhabdomyolysis (muscle breakdown)
Treatment
- Reduced phosphorus in diet
- dialysis
- control hypertension for kidney function
Explain the following about Hyperchloremia
- Signs and symptoms
- possible causes
- treatment
Chloride Cl imbalances > 105 mEq/dL
Signs and symptoms
- hypertension
- fluid retention
- generalised swelling
- peripheral oedema
- cardiac arrhythmias
Possible causes
- Hypernatremia (increased sodium)
- overuse of sodium chloride
- metabolic acidosis
- renal damage
- dehydration
- uncontrolled BGL
- Diabetic insipidus
Treatment
- Reduce sodium in diet
- increase fluid to flus out salt
- PO or IV fluids
- BGL and Insulin management
- Dialysis (renal disease)
Explain the following about Hypochloremia
- Signs and symptoms
- possible causes
- treatment
Chloride Cl Imbalance < 95 mEq/dL
Signs and symptoms
- Hypotension
- tachycardia
- mental status changes
- muscle weakness
- fatigue
Possible causes
- dehydration
- vomiting or diarrhea
- overuse of diuretics
- Addisons disease (adrenals don’t produce enough hormone cortisol)
- metabolic alkalosis
- potassium imbalance
Treatment
- Increase salt intake
- administration of IV potassium
- administration of IV sodium chloride
- rehydration
- limit/reduce diuretic use
Explain the following about IV therapy complications - Air Embolism
- Pathology
- Symptoms
- treatment
Pathology
- entry of air into the vein through IV tubing
Symptoms
- tachycardia
- chest pain
- decreased conscious state
- hypotension
- cyanosis
- dyspnea or couch
Treatment
- clamp tubing
- turn patient to left side
- Notify NUM and Doctor
Explain the following about IV therapy complications - Infiltration
- Pathology
- Symptoms
- treatment
Pathology
- Leaking of IV fluids into surrounding tissue
Symptoms
- at the site - pain, swelling, coolness, numbness
- No blood return
Treatment
- Remove the IV
- Elevate the extremity
- Apply warm or cool compress
- Avoid rubbing the area
Explain the following about IV therapy complications - Infection
- Pathology
- Symptoms
- treatment
Pathology
Entry of microorganism into the body via IV causing infection
Symptoms
- Tachycardia
- redness
- swelling
- chills or fever
- malaise (discomfort)
- nausea and vomiting
Treatment
- remove the IV
- obtain cultures
- notify Dr as may need antibiotics