anatomy of the cell Flashcards
eukaryotic cells
features: an outer membrane inner cytosol cytoskeleton membrane bound organelles within the cytosol
plasmalemma (cell membrane)
separates the cytoplasm from the outside environment
fluid
selectively permeable
a phospholipid bilayer with integral and peripheral proteins and cholesterol in it
organelles in the cytoplasm
mitochondria- energy production
rough ER- protein synthesis
smooth ER- cholesterol and lipid synthesis/detoxification)
Golgi Apparatus- modification and packaging of secretions
lysosomes- hydrolytic enzymes for intracellular digestion
nucleus- contains genetic code
inclusions
they are dispensable and represent components that have been synthesised by the cell itself
cytoskeleton proteins
several functions of a cell are maintained by a set of filamentous cytosolic proteins
microfilaments
composed of the protein actin
intermediate filaments
composed of 6 main proteins, which vary in cell types
the type of protein present can help to identify tumour origins
microtubules
composed of tubulin proteins
2 proteins dyneien and kinesin attach to microtubules and move along them
kinesin
an ATPase that moves towards the cell periphery
dynein
an ATPase that moves towards the call centre
nucleus
mRNA and tRNA are transcribed in the nucleus
rRNA is transcribed in the nucleolus, a small dense area within the nucleus
nucleus
the nucleus contains Euchromatin, and heterochromatin
euchromatin
DNA that is more dispersed and actively undergoing transcription
heterochromatin
DNA that is highly condensed and not actively undergoing transcription
ribosomes
each ribosome has a small subunit which binds RNA and a large subunit that catalyses the formation of peptide bonds
Rough ER
studded with ribosomes
synthesises proteins destined for insertion into membranes or for secretion
Smooth ER
continues the processing of proteins produced in the ER
the SER plays a vital role at the site of synthesis of lipids
golgi apparatus
transport vesicles arrive at the golgi from the SER/RER
they modify and package macromolecules that were synthesised in the ER
intercellular junctions
specialised membrane structures which link individual cells together into a functional unit.
there are three types: occluding, anchoring and communicating
occluding junctions
link cells to form a diffusion barrier
prevent diffusion
anchoring junctions
provide mechanical strength
link submembrane actin bundles of adjacent cells
transmembrane cadherin molecules bind to each other in the extracellular space and to actin of the cytoskeleton
allow the movement of molecules between cells
desmosomes link submembrane intermediate filaments of adjacent cells. very common in the skin where they provide mechanical stability
communicating
allow selective diffusion of molecules between adjacent cells
each junction is a circular patch studded wtih several hundred pores. these pores are produced by connexon proteins