Anatomy of the Brain Flashcards
Which cranial nerves originate from the midbrain?
Trochlear
Oculomotor
Which cranial nerves originate from the pons?
Trigeminal
Vestibulocochlear
Abducent
Facial
Which cranial nerves originate from the medulla?
Glossopharyngeal
Medulla
Accessory
Hypoglossal
Despina is experiencing a hoarse voice, which cranial nerve is likely affected?
Vagus (X)
The Vagus nerve gives rise to the recurrent laryngeal nerve which innervates the muscles of the larynx (voicebox).
Despina is experiencing vertigo, which cranial nerve is likely affected?
Vestibulocochlear (X)
The Vestibulocochlear nerve carries sensations of hearing and balance. A deficit in balance leads to feelings of vertigo.
How can the midbrain be identified?
This can be identified by the large cerebral peduncles anteriorly (inferior aspect of image) and small colliculi.
How can the medulla be identified?
This section is taken in the superior 1/3 of the medulla, which can be referred to as the open medulla, due to the posterior indent formed by the 4th ventricle.
How can the Pons be identified?
Anteriorly the pons bulges forwards, and posteriorly the beginning of the 4th ventricle can be seen.
How else can the medulla be identified?
This region of the medulla is referred to as the closed medulla, due to CSF being enclosed within the central canal of the medulla. This cross section is the most similar to a cross section of the spinal cord.
Which arteries supply the brainstem? (from base to top)
Anterior spinal artery Vertebral artery Posterior Inferior Cerebellar Artery (PICA) Anterior Inferior Cerebellar Artery (AICA) Pontine Branches Basilar Artery Superior Cerebellar Artery (SCA) Posterior Cerebral Artery (PCA)
Upon examination Despina showed decreased pinprick and temperature sensation across the distribution shown in blue.
Based on this information which spinal tract/s are involved?
Spinothalamic
Upon examination Despina showed decreased pinprick and temperature sensation across the distribution shown in blue.
Despina has a lesion to her brainstem. Given the information you have, which of the locations below is most likely?
Trauma to which artery is most likely to have caused this lesion?
Vagus and Vestibulocochlear nerve
This is the location of the Vagus nerve and the Vestibulocochlear nerve. The spinothalamic tract is found lateral to the pyramids within the medulla.
Trauma to the vertebral artery
The vertebral arteries supply the lateral aspect of the medulla, and trauma or thrombus of these vessels can lead to lateral medullary syndrome.
What is the retina and what does it do? Which nerves is it innervated by? What are its features?
This is the innermost layer of the eye (in yellow on the left) that contains photoreceptive cells including rods, cones and photosensitive ganglion cells. They detect light that passes through the cornea, lens and across the vitreous chamber of the eye.
On the right, a photo of the retina demonstrates the appearance of the full retina. The optic disc is where the optic nerve joins the retina. The macula is the location of maximal photoreceptor density (with therefore highest visual acuity, corresponding to the centre of the visual field). Note the blood vessels emerging from the optic disc, and avoiding obstructing light reception near the macula.
How can the retina be examined?
In the 3D model below, look at the left eye, which is illuminated as if being examined with an opthalmoscope. By looking through the pupil with a light, you can examine the retina. Because the apeture you are looking at is small, so you can only see a small portion of the retina, much the same as when examining in real life! In the same way, identify a blood vessel, and follow this to find the optic disc. Examining the appearance of the disc is an important component of a cranial nerve examination.
What is the optic nerve and where is it located?
Optic nerve fibres start at the optic disc at the back of the retina. They are special sensory fibres for sight, receiving visual information from retinal photoreceptors. They exit the eye ball and enter cranium through optic canal. The optic nerves are surrounded by extensions of the cranial meninges and subarachnoid space, which is filled with CSF. The nerve passes posteromedially in the orbit, and through a tendinous ring formed by the base of the four rectus muscles to reach the start of the optic canal. Find this by looking at the right eye of the model below, and after appreciating where the common tendinous ring would be, delete the rectus muscles to examine the base of the orbit and find the optic canal and superior orbital fissure.
What are the optic chiasm and tracts and what do they do?
After travelling through the canal the nerve enters the middle cranial fossa. Each nerve meets to form the optic chiasm. Fibres from the medial aspect of the eye cross over to the opposite side and then continue on via the optic tracts. As a result the optic tracts contain fibres from the lateral (temporal) retina of the eye on the same side and the nasal retina from the opposite site, thus carrying all information from the same half of the visual field.
What are the optic radiations? What do they do?
The paired optic tracts sweep posteriorly and send most axons to synapse in the thalamus, in the lateral geniculate nucleus of the thalamus. Axons of the thalamic neurons project through the internal capsule to form the optic radiations, which project to the primary visual cortex in the occipital lobe, where conscious perception of visual images occurs. Some nerve fibres in the optic tracts send branches to the midbrain, to the superior colliculus which allows a visual reflex centre controlling the extrinsic eye muscles. Some fibres project to the pretectal nuclei in the midbrain to mediate papillary light reflexes. Use the figure below to see how visual information from the left and right halves of the visual fields is conducted along the visual pathway. Note that irrespective of what eye the light comes through, visual information from the left half of the visual field is processed in the right occipital cortex and vica versa.
How can we represent optic pathway defects in visual field perception?
Lesions at any point in the optic pathway can cause defects in visual field perception. We can represent this by drawing two circles to represent each visual field, and shading in black the portion of field loss.
What are the types of defects in visual field perception?
Complete left/right monocular blindness (complete loss of sight in one eye)
Left/right temporal hemianopia (loss of lateral vision in one eye)
Left-right homonymous hemianopia (complete loss of sight in one side of each eye - same side in both eyes)
Bitemporal hemianopia (tunnel vision)
Which lesions cause which types of blindness?
See anatomy e-learning
Joseph can only see through the inner halves of his fields of vision.
What type of visual field defect does Joseph have?
Which bit of the optic pathway has been affected?
Bitemporal hemianopia
Decussating fibres at the optic chiasm
You are concerned about the intracranial pathology that may be causing this bitemporal hemianopia, and organise a CT scan of his head. Here is a saggital section of the scan: (mass shown in the brain)
Pituitary adenoma
What are pituitary adenomas and what do they cause? How may they be treated?
Pituitary adenomas that are non secretory can grow to large sizes and patients present due to compression effects on nearby structures. Jonathan underwent transphenoidal resection of the lesion and made a full recovery. Remind yourself of the relationship between the pituitary, hypothalamus and optic chiasm and how the pituitary might be approached via the nasal cavity and through the sphenoid bone in the 3D model below.
Which cranial nerves cause eye movements?
3rd, 4th and 6th
What 3 types of movements is the eye capable of?
The eye is capable of vertical, horizontal and rotary movement. The muscles responsible for this movement are known as the extra-ocular eye muscles.
When is rotation of the eyeball used?
Whilst you cannot rotate your eyes on demand, if you fix your gaze on one point and tilt your head the eyes rotate to keep your gaze.
Which muscles, and how many, control eye movement?
There are 6 extra-ocular muscles controlling eye movement. Four recti, and two obliques: Lateral rectus Medial rectus Superior rectus Inferior rectus Superior oblique Inferior oblique
Where do the four recti muscles originate from?
Four recti muscles arise from a common tendinous ring and insert into the sclera just posterior to the cornea.
What do the levator palpabrae superioris and the tarsal muscles do? How are they innervated?
These muscles do not act on the eye, but contract to raise the eyelid. Closing of the lids requires relaxation of the levator palpebral muscle (CN III). Orbicularus oculi (innervated by CN VII) is located in the eyelids and is used to close the eyelids.
What is important to remember about the external ocular muscles?
It is important to remember that the external ocular muscles rarely act in isolation. The action of the other muscles is complex, as their primary line of pull is oblique to the axis of the globe.
What does each extraocular muscle do?
Superior rectus: look upward and medially
Inferior rectus: look downward and medially
Lateral rectus: look laterally
Medial rectus: look medially
Inferior oblique: look upward and laterally
Superior oblique: look downward and laterally
What is the action of the medial and lateral recti?
The action of the medial and lateral recti is straightforward: medial rectus adducts the globe (eyeball) and lateral rectus abducts the globe, without elevation or depression.
What is the action of the superior and inferior recti?
The superior and inferior recti act to elevate and depress the globe respectively. However as the orientation of the muscle is not inline with the angle of the orbit, the recti muscles also create secondary actions.
Superior rectus: elevation, adduction and intorsion
Inferior rectus: depression, adduction and extorsion
What is the action of the superior and inferior oblique?
The superior and inferior oblique depress and elevate the globe respectively, and as with the recti muscles create secondary actions.
Superior oblique: Depression, abduction and intorsion
Inferior oblique: Elevation, abduction and extorsion
What clinical testing can be done to test the extraocular muscles?
So the extraocular muscles work in conjunction to cancel out the accessory movements of each other clinical testing is not straight forward.
The action of the medial and lateral recti is straightforward: medial rectus adducts the eye and can be tested by looking medially. Lateral rectus abducts the globe and can be tested by looking laterally
To test the remaining 4 muscles the eye is abducted or adducted so that only one set of muscles can act.
When the eye is ABDUCTED the superior and inferior recti act to elevate and depress the globe respectively.
When the eye is ADDUCTED the superior and inferior oblique depress and elevate the globe respectively.
Through which skull base foramina do the 3rd, 4th and 6th cranial nerves pass?
Superior orbital fissure