anatomy of lymph and spleen Flashcards
what are lymphatic channels
blind ended vessels that permit passive undirectional flow (valves) of lymphatic fluid
what do afferent lymphatic channels do
drain lymph through the capsule in to the peripheral sinus
how is lymph filtered
fluid percolates through the node
immune reactions can be triggered
cell can enter the node: immune cells or cancer cells
virchows node indicator
metastatic abdominal malignancy
what is virchows node
it is the thoracic duct end node
receives afferent lymphatic drainage from left head, neck, chest, abdomen, pelvis and bilateral lower extremities
what is troisier sign
enlargement of a left sided supraclavicular lymph node
what is sentinel lymph node
the first lymph node to which cancer cells are most likely to spread
where would metastatic cells first be found in a lymph node
the subcapsular sinus
origins of lymphoid cells
haematopoietic stem cells (foetal liver/postnatal bone marrow) > precursor lymphoid cells > bone marrow (B-cell maturation) and thymus (T-cell maturation) > secondary lymphoid organs
causes of lymphadenopathy
local inflammation
systemic inflammation
malignancy
other: sarcoidosis, kikuchi’s lymphadenitis, castlemans disease, IgG4 related disease
stimulation of predominantly B cell response in lymph node
auto-immune condition
infections
stimulation predominant phagocytic response in lymph node
non-specific
draining a tumour site
stimulation predominantly T-cell response in lymph node
viral infections
drugs- phenytoin
dermatopathic
vasculature of the spleen
supplied by splenic artery (branch of coeliac) and drained by splenic veni
what does white pulp of the spleen compromise of
periarteriolar lymphoid sheath
- CD4+ lymphoid cells
expanded by lymphoid follicles
