Anatomy of a cell Flashcards
What are the levels of structural organisation?
Cell
Tissue
Organs
Organ system
Organism
What are the contents of a typical cell?
plasma membrane
cytoplasm
cytoskeletal elements
nucleus
mitochondria
endoplasmic reticulum
ribosomes
golgi complex
What are three characteristics of the cell membrane?
- Fluid in nature
- Can change its shape easily
- Separated the cytoplasm from the outside environment
Under an electron microscope what is the structure of the cell membrane called?
trilaminar structure
What does the trilaminar structure consist of?
Phospholipid bilayer
Cholesterol
Proteins
What are the two different types of proteins in a cell membrane?
Integral and peripheral
What do integral and peripheral proteins act as (5)?
Receptors
Channels
Transporters
Enzymes
Cell attachment proteins
What does the cell membrane do?
Acts as a selective structural barrier between the cell and the outside environment
What is the cell membrane highly permeable to?
Water
Oxygen
Small hydrophobic molecules
What is the cell membrane virtually impermeable to?
Charged ions
How do larger molecules pass through the cell membrane?
By utilizing transport mechanisms like exocytosis and endocytosis
What does the cytoplasm consist of?
The cytosol and cytoskeleton
What is the cytosol?
A solution of proteins, electrolytes and carbohydrates
What is the size of microfilaments?
7nm
What are microfilaments composed of?
Fine strands of protein actin
What is the space inside the cell called?
Intracellular space
What is the space between the cells called?
Intercellular space
Where do you find microfilaments?
Under the cell membrane
What do microfilaments do?
Form a network which provides mechanical support, determines cell shape and allows movement of the cell surface.
What is the size of intermediate filaments?
10-15nm in diameter
What is the physical description of intermediate filaments?
They form a network throughout the cytoplasm, that can extend a ring surrounding the nucleus towards the plasma membrane.
What do the intermediate filaments do?
Bind intracellular elements together and to the cell membrane
What is the size of microtubules?
24nm
What are microtubules composed of?
Two types of tubulin subunits, alpha and beta in an alternating array
Where do microtubules originate from?
They originate from a special organising centre called the centrosome
What does it mean that microtubules are polar?
Polymerize in the central portion of the cell
What is Dynein when talking about microtubules?
Dynein is an ATPase that moves towards the cell centre
What is Kinesin when talking about microtubules?
Kinesin is an ATPase that moves toward the cell periphery?
Why are proteins Kinesin and Dynein important?
They are important in the movement of components in cells with long processes
What do dynein and kinesin do to microtubules?
They attach to the microtubules and move along them.
They associate with the membranes of organelles and vesicles and drag them along the microtubule
What is an example of microtubules and dynein and kinesin?
The long axonal process of many neurons
What best describes the purpose of microtubules?
They act as the motorway network of the cell.
What are intermediate filaments made of?
Keratin
What is a nucleus enclosed by?
A double layered nuclear envelope
What is a nucleus made up of?
Inner & outer nuclear membrane
Nuclear pores
What are the two types of DNA found in a nucleus?
Euchromatin and Heterochromatin
What is Euchromatin?
Dispersed DNA actively undergoing transcription
What is Heterochromatin?
Condensed DNA not undergoing transcription
What is the location of RNA synthesis?
The nucleus
Where is rRNA transcribed?
In the nucleolus
What is the nucleolus?
a 1-3um diameter dense area within the nucleus
Where is mRNA and tRNA transcribed?
In the nucleus
What are the nuclear pores doing?
They are in communication with Rough Endoplasmic Reticulum
How does the endoplasmic reticulum appear in micrographs?
As flattened membrane sheets or elongated tubular profiles
What does reticulum stand for?
Net like structure
What are the two types of endoplasmic reticulum?
Rough endoplasmic reticulum
Smooth endoplasmic reticulum
What is an endoplasmic reticulum?
Network of intercommunicating channels and sacs formed by a continuous membrane
What happens in the rough endoplasmic reticulum?
Synthesis of proteins destined for insertion into membranes or for secretion