Anatomy Midterm 1 Flashcards
Cellular level
Cells and their surroundings are made up of molecules. For example, a phospholipid molecule is a structural component of the plasma membrane
Phospholipid molecule –> phospholipid membrane –> forms most of the plasma membrane of a cell
Chemical level
Atoms combine to form molecules. Molecules combine to form the macromolecules (carbohydrates, lipids, proteins, and nucleic acids)
Atoms –> molecule –> hemoglobin, a protein
Tissue level
Tissues consist of similar types of cells and associated extra cellular material. Epithelial tissue forms the inner lining of blood vessels
Organ level
An organ is a discrete structure made up of multiple tissue types. Examples include blood vessels, the liver brain, and femur
Organ system level
An organ system is a unified group of organs and tissues that perform a specific function. The example shown here is the cardiovascular system, showing blood vessels, blood, and the heart
Organismal level
The whole person is the most complex level of organization, the Organismal level, resulting from the simpler levels working interdependently
Structural levels of complexity in order (6)
Chemical level Cellular level Tissue level Organ level Organ system level Organismal level
Describe body in anatomical position
Palms facing out, standing up straight and facing forward
Regional terms of the body in anatomical position
Cephalic (head) Cervical (neck) Thoracic (chest) Upper limb (arms and wrists) Abdominal Pelvic (groin) Manus (hand) Pubic (genital) Lower limb (hip, thigh, leg) Pedal (foot, ankle) Dorsum (back)
Superior (cranial)
Towards the head and or upper part of a structure of the body, above
The head is superior to the abdomen
Inferior (caudal)
Away from the head and or toward the lower part of a structure of the body, below
The intestines are inferior to the liver
Medial
Toward or at the midline of the body, on the inner side of
The heart is medial to the lungs
Lateral
Away from the midline of the body, on the outer side of
The thumb is lateral to the pinky
Proximal
Closer to the origin of the body part or the point of attachment of a limb to the body trunk
The elbow is proximal to the wrist
Distal
Farther from the origin of a body part or the point of attachment of a limb to the body trunk
The knee is distal to the thigh
Ipsilateral
On the same side
The right hand and the right foot are ipsilateral
Contralateral
On opposite sides
The right hand and left foot are contralateral
Anterior (ventral)
Toward or at the front of the body, in front of
The sternum is anterior to the heart
Posterior (dorsal)
Toward or at the back of the body, behind
The vertebra is posterior to the heart
Superficial (external)
Toward or at the body surface
The skin is superficial to the skeletal muscles
Deep (internal)
Away from the body surface, more internal
The lungs are deep to the skin
Frontal plane
Front view
Can see left and right lungs, liver, heart, stomach, arm
Median (midsagittal) plane
Side view
Can see rectum, vertebral column, intestines
Transverse plane
Cut body in half, top view
Can see liver, subcutaneous fat layer, spinal cord, aorta, body wall, pancreas, spleen
Cranial cavity
Skull
Vertebral cavity
Neck, spine
Thoracic cavity
Contains heart and lungs
Abdominal cavity
Contains digestive viscera
Pelvic cavity
Contains urinary bladder, reproductive organs, and rectum
Abdomino-pelvic cavity
Abdomen
Ventral body cavity
Thoracic and abdominopevlic cavities
All body cavities
Cranial cavity Vertebral cavity Thoracic cavity Abdominal cavity Pelvic cavity Abdominopelvic cavity Ventral body cavity
Body cavities and membranes
Visceral peritoneum Peritoneal cavity (with serous fluid) Stomach Kidney (retroperioneal) Wall of body trunk Parietal peritoneum Liver
What is the intersection point for the horizontal and vertical lines that divide the abdomen into 4 quadrants?
Navel
Right upper quadrant (RUQ)
Liver, gallbladder
Left upper quadrant (LUQ)
Diaphragm, spleen, stomach, transverse colon of large intestine
Right lower quadrant (RLQ)
Ascending colon of large intestine, small intestine, cecum, appendix
Left lower quadrant (LLQ)
Descending colon of large intestine, initial part of sigmoid colon, urinary bladder
The production of a protein
- Protein containing vesicles pinch off rough ER and migrate to fuse with membranes of Golgi apparatus
- Proteins are modified within the Golgi compartments
- Proteins are then packaged within different vesicles types, depending on their ultimate destination
3 main components of cells
Plasma membrane
Cytoplasm
Nucleus
Mitochondria
The site of oxidative phosphorylation and the aerobic production of ATP
Have their own circular ring shaped DNA that is separate from your nuclear DNA
Generate most of the cell’s energy, most complex organelle
More abundant in energy -requiring cells, like muscle cells and sperm
Simple diffusion
Fat-soluble molecules directly through the phospholipid bilayer down their concentration gradient
Osmosis
Diffusion of water through the lipid bilayer
Facilitated Diffusion
An integral protein that spans the plasma membrane enables the passage of a particular solute across the membrane
Active Transport
Some transport proteins use ATP as an energy source to actively pump substances across the plasma membrane against their concentration gradient
Exocytosis
A mechanism that moves substances out of the cell
Substance is enclosed in a vesicle
The vesicle migrates to the plasma membrane
Proteins from the vesicles (v-SNAREs) bind with membrane proteins (t-SNAREs)
The lipid layers from both membranes bind, and the vesicle releases its contents to the outside of the cell
Phagocytosis
The cell engulfs a large particle by forming projecting pseudopods (“false feet”) around it and enclosing it with a membrane sac called a phagosome. The phagosome then combines with a lysosome, and its contents are digested. Vesicle may or may not be protein-coated but has receptors capable of binding to microorganisms or solid particles
Receptor-mediated Endocytosis
Extracellular substances bind to specific receptor proteins in regions of protein-coated pits, enabling the cell to ingest and concentrate specific substances in protein-coated vesicles. The ingested substance may simply be released inside the cell, or combined with a lysosome to digest contents, Receptors are recycled to the plasma membrane in vesicles
Pinocytosis
The cell “gulps” drops of extracellular fluid containing solutes into tiny vesicles. No receptors are used, so the process is nonspecific. Most vesicles are protein-coated
Ribosomes
Dense particles consisting of two subunits, each composed of ribosomal RNA and protein; free or attached to rough ER
Function: the sites of protein synthesis
Rough endoplasmic reticulum
Membrane system of sacs and tubules externally studded with ribosomes
Function: makes proteins that are secreted from the cell; makes the cell’s membranes
Smooth endoplasmic reticulum
Membranous system of sacs and tubules; free of ribosomes
Function: site of lipid and steroid hormone synthesis, lipid metabolism, and drug detoxification
Golgi apparatus
A stack of smooth membrane sacs close to the nucleus
Function: packages, modifies, and segregates proteins for secretion from the cell, inclusion in lysosomes, and incorporation into the plasma membrane
Lysosomes
Membranous sacs containing acid hydrolyses
Function: sites of intracellular digestion
Mitochondria
Rodlike, double-membrane structures; inner membrane folded into projections called cristae
Function: site of ATP synthesis; powerhouse of the cell
Peroxisomes
Membranous sacs of oxidase enzymes
Function: the enzymes detoxify a number off toxic substances; the most important enzyme, catalase, breaks down hydrogen peroxide
Fluid Mosaic Model
Depicts the plasma membrane as a double layer, or bilayer, of lipid molecules with protein molecules embedded within it
Apoptosis
Programmed cell death
This process of controlled cellular suicide eliminates cells that are stressed, unneeded, excessive, or aged
Controlled cell death
Necrosis
Death of a cell or group of cells due to injury or disease
Acute injury causes the cells to swell and burst, and they induce an inflammatory response
Uncontrolled cell death
Hyperplasia
Excessive cell proliferation
Unlike cancer cells, hyper plastic cells retain their normal form and arrangement within tissues
Cells increase in number but not in size
Hypertrophy
Growth of an organ or tissue due to an increase in the size of its cells
A normal response of skeletal muscle cells to exercise
Cell Differentiation
When cells begin to specialize early in embryonic development
Some cells connect body parts or cover and line organs, some produce movement and move body parts, some store nutrients, some fight disease, some gather information and control body functions, and some reproduce
Tube-within-a-tube Body Plan
The inner tube extends from the mouth to the anus and includes the respiratory and digestive organs
The outer tube consists of the axial skeleton and associated axial muscles that make up the outer body wall, and nervous structures
Neurulation
As the notochord develops, it signals the overlying ectoderm to start forming the spinal cord and brain
3 Germ Layers in Embryological Development
Endoderm
Mesoderm
Ectoderm
Ectoderm
Epidermis, hair, nails, glands of skin
Brain and spinal cord
Neural crest and derivatives (sensory nerve cells and other nervous system structures, pigment cells, bones and blood vessels of the head)
Formed from epiblast cells that stay on dorsal surface
Endoderm
Epithelial lining and glands of digestive and respiratory tracts
Formed from migrating cells that replace the hypoblast
Mesoderm
Notochord: nucleus pulpous of intervertebral discs
Somite: vertebrae and ribs, dermis of dorsal body region, trunk and limb musculature
Intermediate mesoderm: kidneys, gonads
Lateral plate mesoderm –> Somatic mesoderm: parietal serosa, dermis of ventral body region, connective tissues of limbs (bones, joints, and ligaments), Spanchnic mesoderm: wall of digestive and respiratory tracts (except epithelial lining), visceral serosa, heart, blood vessels
Formed between epiblast and endoderm
Identify 1 adult tissue derivative from each germ layer
Ectoderm: brain, spinal cord, epidermis of skin
Endoderm: respiratory tubes, digestive organs, urinary bladder
Mesoderm: kidneys, gonads, heart, blood vessels
Basic functions of the epithelial surfaces that separate the internal you from the external environment
Protect, sensory reception, diffusion, secretion, absorption, ion transport, filtration and lubrication
3 basic shapes of epithelial cells
Squamous, cuboidal and columnar
Squamous
One layer: diffusion and filtration
More than one layer: protection
Cuboidal Columnar
One layer: secretion and absorption; ciliated types propel mucus or reproductive cells
More than one layer: protection; these tissue types are rare in humans
Transitional
More than one layer: protection; stretching to accommodate dissension of urinary structures
What are epithelial layers distinguished as
Simple and stratified
Simple squamous epithelium
Description: single layer of flattened cells with disc-shaped central nuclei and sparse cytoplasm; the simplest of the epithelia
Function: allows passage of materials by diffusion and filtration in sites where protection is not important; produces lubricating fluid in serosae
Location: kidney glomeruli; air sacs of lungs; lining of heart, blood vessels, and lymphatic vessels; lining of ventral body cavity (serosae)
Simple cuboidal epithelium
Description: single layer of cube like cells with large, spherical central nuclei
Function: secretion and absorption
Location: kidney tubules; ducts and secretory portions of small glands; ovary surface
Simple columnar epithelium
Description: single layer of tall cells with round to oval nuclei; some cells bear cilia; layer may contain mucus-secreting unicellular glands (goblet cells)
Function: absorption; secretion of mucus, enzymes, and other substances; ciliated type propels mucus (or reproductive cells) by ciliary action
Location: nonciliated type lines most of the digestive tract (stomach to anal canal), gallbladder, and excretory ducts of some glands; ciliated variety lines small bronchi, uterine tubes, and some regions of the uterus
Pseudostratified columnar epithelium
Description: single layer of cells of differing heights, some not reaching the free surface; nuclei seen at different levels; may contain mucus-secreting goblet cells and bear cilia
Function: secretion, particularly of mucus; propulsion of mucus by ciliary action
Location: nonciliated type in male’s sperm-carrying ducts and ducts of large glands; ciliated variety lines the trachea, most of the upper respiratory tract
Stratified squamous epithelium
Description: thick membrane composed of several cell layers; basal cells are cubical or columnar and metabolically active; surface cells are flattened (squamous); in the keratinized type, the surface cells are full of keratin and dead; basal cells are active in mitosis and produce the cells of the more superficial layers
Function: protects underlying tissues in areas subjected to abrasion
Location: nonkeratinized type forms the moist linings of the esophagus, mouth, and vagina; keratinized variety forms the epidermis of the skin, a dry membrane
Transitional epithelium
Description: resembles both stratified squamous and stratified cuboidal; basal cells cuboidal or columnar; surface cells dome shaped or squamous-like, depending on degree of organ stretch
Function: stretches readily and permits dissension of urinary organ by contained urine
Location: lines the ureters, bladder, and part of the urethra
3 types of cell junctions
Tight junctions
Desmosomes
Gap junctions
Tight junctions
Impermeable junctions prevent molecules from passing through the intercellular space
Desmosomes
Anchoring junctions bind adjacent cells together and help form an internal tension-reducing network of fibers
Gap junctions
Communicating junctions allow ions and small molecules to pass from one cell to the next for intercellular communication
Microvilli
Fingerlike extensions of the plasma membrane of apical epithelial cells
Most abundant on epithelia that absorb nutrients or transport ions
Maximize the surface area across which small molecules enter or leave cells
Most common locations: small intestine and kidney tubules
Cilia
Whiplike, highly motile extensions of the apical surface membranes of certain epithelial cells
Membrane
Epithelia + underlying connective tissue
4 Body Membranes
Mucous, serous, cutaneous, and synovial
Where do connective tissue cell lines come from
Mesenchyme (mesoderm)
3 types of dense connective tissue
Regular, irregular, and elastic
Dense irregular tissue
Description: primarily irregularly arranged collagen fibers; some elastic fibers; major cell type is the fibroblast; defense cells and fat cells are also present
Function: able to withstand tension exerted in many directions; provides structural strength
Location: fibrous capsules of organs and of joints; dermis of the skin; submucosa of digestive tract
Dense regular tissue
Description: primarily parallel collagen fibers; a few elastic; major cell type is the fibroblast
Function: attaches muscles to bones or to muscles; attaches bones to bones; withstands great tensile stress when pulling force is applied in one direction
Location: tendons, most ligaments, aponeuroses
Elastic tissue
Description: dense regular connective tissue containing a high proportion of elastic fibers
Function: allows recoil of tissue following stretching; maintains pulsatile flow of blood through arteries; aids passive recoil of lungs following inspiration
Location: walls of large arteries; within certain ligaments associated with the vertebral column; within the walls of the bronchial tubes
3 types of cartilage
Hyaline, fibrocartilage, and elastic
Hyaline Cartilage
Chondrocytes, no visible fibers
Description: amorphous but firm matrix; collagen fibers form an imperceptible network; chondroblasts produce the matrix and, when mature (chondrocytes), lie in lacunae
Location: forms most of the embryonic skeleton; covers the ends of long bones in joint cavities; forms costal cartilages of the ribs; cartilages of the nose, trachea, and larynx
Fibrocartilage
Chondrocytes, fibers
Description: matrix similar to but less firm than that in hyaline cartilage; thick collagen fibers predominate
Location: intervertebral discs; pubic symphysis; discs of knee joint
Elastic Cartilage
Chondrocytes, elastic fibers
Description: Matrix similar to but less firm than that in hyaline cartilage; thick collagen fibers predominate
Location: intervertebral discs; pubic symphysis; discs of knee joint