Anatomy & Branchial Arches Flashcards
BRANCHIAL ARCHES Definitions - epidemiology
Defintion A congenital anomaly of the neck due to disturbances in the complex development of the branchial apparatus of the foetus
Btwn weeks 4-7 of development
Epidemiology 17% paediatric neck masses
Definitions:
Arch- mesoderm
Cleft- ectoderm
Pouch- endoderm
Branchial membrane- cleft and pouch in contact. Only preserved in 1st arch (i.e. TM)
BRANCHIAL ARCHES Theories
Theories of development:
- Branchial remnant
- Salivary gland inclusion in a lymph node
- Squamous metaplasia of a LN
- Thymopharyngeal theory (persistent connection between thymus and its pharyngeal origin)
BRANCHIAL ARCHES Embryology
Embryology:
4/40- 4 arches arise at lateral pharynx and grow forward to meet in midline - V and VI are rudimentary
5/40- development of cervical sinus (2nd arch grows over 2, 3, 4, clefts)
6/40- 6 Hillocks of His develop to form pinna (1, 2, 3- 1st arch, 4, 5, 6- 2nd arch)
7/40- skin smooth over anterior neck
BRANCHIAL ARCHES Pathology
Pathology:
Thin-walled cystic structures. 90% contain squamous epithelial lining. 10% contain respiratory epithelium (ciliated columnar)
Nodular or diffuse lymphoid infiltrate often with germinal centres
Cyst fluid contains cholesterol crystals
BRANCHIAL ARCHES Syndromes associated
Syndromic associations:
- Treacher-Collins Syndrome
- Goldenhar
- Di George
- Pierre-Robin Sequence
- Branchio-Oto-Renal
1st BRANCHIAL ARCH CYSTS Work type 1
Work Type 1:
Ectodermal - Doesn’t communicate with EAC - Presents as mass around lower ear - Runs parallel to EAC. Involves parotid tissue, superior to VII
1st BRANCHIAL ARCH CYSTS Work Type 2
Work Type 2:
Ectoderm and mesoderm - Cartilage + skin adnexa (hair follicles, sebaceous glands, sweat glands) - Present as mass around ear, AoM / SCM / otorrhoea - Duplication anomaly of membranous and cartilagenous EAC - More intimately assoc with VII (may run through main trunk) - Myringeal band- floor of hypotympanum to umbo - Pathognomonic - MRI will demonstrate its tract - High recurrence rate - ave 2.4 procedures/pt
8-10% of all branchial arch anomalies
Cysts twice as common as sinuses/fistulae
1st BRANCHIAL ARCH CYSTS Clinical & radiological findings Recurrence rate % of all BA anoms
- Myringeal band- floor of hypotympanum to umbo
- Pathognomonic
- MRI will demonstrate its tract - High recurrence rate - ave 2.4 procedures/pt
8-10% of all branchial arch anomalies
Cysts twice as common as sinuses/fistulae
2nd ARCH FISTULA TRACT AND CYSTS Classification
Classification of 2nd arch cysts:
Type 1- superficial at border of SCM
Type 2- between SCM and IJV
Type 3- in the carotid bifurcation
Type 4- in the pharyngeal wall
2nd ARCH FISTULA TRACT AND CYSTS Describe
External: lower 1/3 of neck, anterior border SCM
Fistula tract: - caudal to platysma, through deep fascia to carotid sheath - below stylohyoid and above (superficial) IX and XII - between ICA, ECA
Enters pharynx- anterior aspect of posterior faucial pillar
2nd ARCH FISTULA TRACT AND CYSTS Recurrence
Recurrence rates in 2nd arch surgery (Mayo clinic, n=208):
- Prior surgery = 21%
- Prior infection = 14%
- No infection/surgery = 3%
3rd ARCH FISTULA TRACT Describe & course
Fistula tract:
External: as for 2nd arch fistula - lower 1/3 of neck, anterior border SCM
Course: inferior to CN IX, superior to CN XII, posterior to ICA
Internal: pierces thyrohyoid membrane to open in upper piriform fossa
4th ARCH FISTULA TRACT Describe & course
Fistula tract:
External: as for 2nd/3rd arch fistulae - lower 1/3 of neck, anterior border SCM
Course: deep to platysma, loops over CN XII, turns caudally in carotid sheath, loops around 4th arch artery (R SCA, L arch of aorta)
Internal: pierces cricothyroid membrane, opens to piriform apex
PARAPHARYNGEAL SPACE Boundaries
An inverted pyramid shape
Potential space lateral to upper pharynx, filled with fat and areolar tissue
Boundaries
Superior (base) - base of skull (temporal/sphenoid) Inferior (apex) - junction of digastric tendon with lesser horn of hyoid
Anterior - Pterygomandibular raphe and medial pterygoid fascia
Posterior - Pre-vertebral fascia
Medial - Buccopharyngeal fascia overlying sup constrictor and pharyngobasilar fascia. Fascia from TVP to medial pterygoid
Lateral - Fascia overlying medial pterygoid, mandibular ramus, PBD and deep lobe of parotid
PARAPHARYNGEAL SPACE Divisions
Division is by the Styloid process tensor-vascular-styloid fascia
- Prestyloid - Fat, deep lobe parotid, LNs, Styloglossus, Stylopharyngeus, V3 branches, TVP, LVP, IMA, asc palatine a, asc pharyngeal a
- Post-styloid - Cartoid sheath (ICA, IJV, X), SNS trunk, IX, XI, XII, IMA, paraganglionic tissue
PARAPHARYNGEAL SPACE Communcations xxxx x
Communications
Medial - peritonsillar space
Anterolateral - Masticator space
Posteromedial - Retropharyngeal space
Inferomedial - Submandibular space
Lateral - Parotid space
Posterior - Carotid sheath contents
Superior - ITF
Pathology: 80% benign, 20% malignant (mostly salivary)
TEMPORAL FOSSA Boundries
Boundaries:
Superiorly - by the superior temporal line.
Inferiorly - zygomatic arch (arbitrary designation)
Floor - bones of the lateral aspect of the skull, including a portion of the frontal, GW sphenoid, the temporal, and the parietal bones
Separated inferior from infratemporal fossa by the infratemporal crest of the greater wing of sphenoid
TEMPORAL FOSSA Contents
Contents: Temporalis muscle - attaches superiorly to inferior temporal line
TEMPORAL FOSSA Superior Temporal Line
Superior temporal line:
Anteriorly - Zygomatic process of the frontal bone
Arches posteriorly over the parietal bone before descending to the temporal bone, where it blends into the zygomatic process
Attachment of temporalis fascia
Vertical groove on squamous temporal bone = superficial temporal vessels
INFRATEMPORAL FOSSA Boundaries
A space lying beneath the base of skull between side wall of pharynx and ramus of mandible
Boundaries
Superior - IT surface of greater wing of sphenoid, Squamous temporal bone - Continous with temporal fossa laterally (infratemporal crest marks this transition)
Inferior - Opens into the neck
Anterior - Posterior surface of maxilla and IOF
Posterior - Upper carotid sheath
Medial - Lateral surface of lateral pterygoid plate, TVP/LVP/superior constrictor, pterygomaxillary fissure (connects to PPF)
Lateral - Ramus of mandible and its coronoid process
INFRATEMPORAL FOSSA Contents xxxx
Contents: Medial pterygoid Lateral pterygoid Insertion of temporalis into coronoid process Internal maxillary artery Pterygoid venous plexus V3 and branches (+ otic ganglion, chorda tympani) PSAN (of V2)
MUSCLES OF MASTICATION xxxxxx x
1. Medial pterygoid
- Origin - Deep head: Medial surface LPP, fossa between MPP/LPP - Superficial head: maxillary tuberosity and pyramidal process of palatine bone
- Insertion - Angle of mandible (broad insertion)
2. Lateral pterygoid
- Origin - Upper head - Infratemporal surface of skull (GW sphenoid) - Lower head - Lateral surface of LPP - Insertion - Pterygoid fovea (beneath medial end of mandibular head) - Articular disc and capsule of TMJ 3. Temporalis - Origin - Temporal fossa
- Insertion - Coronoid process and down ramus to buccinator insertion
4. Masseter
- Origin - Zygomatic arch
- Insertion - 3 heads of masseter fuse anteriorly - Posteriorly they diverge from one another - Superficial - broad attachment - body, angle, ramus - Intermediate - ramus - Deep - ramus - Between the heads: sup / intermed = masseteric artery, intermed / deep = masseteric nerve
PTERYGOPALATINE FOSSA Def & boundries
Lies between back of maxilla and pterygoid process of sphenoid
Boundaries:
- Posterior - sphenoid bone - a. root of pterygoid process (incl Vidian Canal), b. greater wing (incl Foramen Rotundum)
- Medial - palatine bone (incl notch for SP foramen)
- Anterior - posterior wall of maxilla - leads to IOF
- Roof - a. body of sphenoid, b. orbital process of palatine bone
- Lateral - pterygomaxillary fissure (leads to ITF)
PTERYGOPALATINE FOSSA Contents
Contents:
1. V2 - Meningeal branch (to MCF) - Zygomatic Nerve (arises in PPF and runs to IOF above V2), takes the secretomotor fibres from the ganglion (pass to lacrimal gland via Lacrimal branch of V1) - Post Sup Alveolar N - Exits via Pterygomaxillary Fissure to posterior surface of maxilla - V2 exits through IOF to become ION - Ganglionic branch
2. Pterygopalatine Ganglion - Connected to V2 by short trunk (inf/med to V2) - Only cell bodies are PSNS (SNS and sensory fibres ‘relay station’) - Autonomic root is Vidian N (PSNS- GSPN, SNS- ICA plexus via DPN) - Fibres arise in Superior Salivary Nucleus 3. Maxillary Artery 5 branches accompany the 5 nerves of the PPG - Vessels lie in front of nerves
PTERYGOPALATINE Ganglion Branches
Branches of the Pterygopalatine Ganglion:
1. Nasopalatine N - SP foramen - Septum + incisive gum of hard palate (descends down incisive foramen)
2. Lat Post Sup Nasal Ns - SP foramen - Postersup quadrant of LNW
3. Greater Palatine N - GP foramen/canal (junction of maxilla and palatine bone) - Mucosa of hard palate - Nasal branches - posteroinf quadrant LNW + med wall max sinus
- Lesser Palatine Ns - Lesser palatine foramina (behind GPN) - Soft palate and tonsil mucosa
- Pharyngeal N - Palatovaginal canal - Nasopharynx mucous membrane
- Orbital branches - IOF - Orbital periosteum, orbitalis muscle - Sphenoid/ethmoid sinuses
TONGUE xxxx
Mass of skeletal muscle with midline fibrous septum covered by mucous membrane - Keratinising stratified squamous epithelium Parts of the tongue: - Dorsum, tip, ventral surface, base (BOT is oropharynx not oral cavity)
Papillae:
- Filiform- velvety appearance
- Fungiform- discrete pink pinheads (bears the taste buds)
- Circumvallate- 12, form a V in front of sulcus terminalis (marks division of oral cavity and oropharynx
Folds: Median glossoepiglottic, lateral glossoepiglottic
Muscles:
- Intrinsic x4 shape no bony attachments - longitudinal (sup/inf), vertical, transverse
- Extrinsic x 4 position - Genioglossus - bulk of tongue. Genial tub to mucous memb + hyoid (i.e. geniohyoglossus) - Hyoglossus - length of greater horn/body of hyoid (free ant + post borders) - Styloglossus - low/ant styloid to interdig with hyoglossus - Palatoglossus - undersurface of palate to interdig with styloglossus
TONGUE Parts
Mass of skeletal muscle with midline fibrous septum covered by mucous membrane - Keratinising stratified squamous epithelium Parts of the tongue:
- Dorsum, tip, ventral surface, base (BOT is oropharynx not oral cavity)
TONGUE Papillae
Papillae:
- Filiform- velvety appearance
- Fungiform- discrete pink pinheads (bears the taste buds)
- Circumvallate- 12, form a V in front of sulcus terminalis (marks division of oral cavity and oropharynx
TONGUE Folds & Muscles
Folds:
Median glossoepiglottic, lateral glossoepiglottic
Muscles:
- Intrinsic x4 shape no bony attachments - longitudinal (sup/inf), vertical, transverse
- Extrinsic x 4 position - Genioglossus - bulk of tongue. Genial tub to mucous memb + hyoid (i.e. geniohyoglossus) - Hyoglossus - length of greater horn/body of hyoid (free ant + post borders) - Styloglossus - low/ant styloid to interdig with hyoglossus - Palatoglossus - undersurface of palate to interdig with styloglossus
TONGUE Blood & nerve supply
Blood supply: Lingual A. - above greater horn of hyoid - Dorsal lingual branches to posterior tongue Asc Pharyngeal, tonsil branches of Facial- small contributions Lingual v. - tributaries run with Lingual a. Deep Lingual v. (visible in FOM) + sublingual v. — vena comitants of XII
Nerve supply: Anterior 2/3 - sensation- Lingual N., Taste- chorda tympani Posterior 1/3 - IX (sensation + taste), X (internal branch of SLN- ant valleculla) Motor - all CN XII except palatoglossus (pharyngeal plexus)
** taste travels to nucleus tractus solitarius
TONGUE Embryology
Embryology:
Appears during Week 4 - as the tuberculum impar.
2 lateral swellings appear either side of the tuberculum —> fuse to form the midline fibrous septum (Arch I)
Base of tongue is formed from the hypobranchial eminence (Arch III). This joins with the lateral swellings at the sulcus terminalis to form the tongue
Tongue muscles derived from suboccipital myotomes (ie not supplied by branchial arch nerves - XII instead)
Migrate forward into the sac of mucous membrane derived from arches I, III, IV
PHARYNX Def Layers
BOS to C6 (12cm), open anteriorly
Divided to Naso-, Oro-, Hypo- - Free edge of soft palate - Tip of epiglottis (level of hyoid)
Layers of Pharynx
- Mucosa
- Submucosa- thickened superiorly as the Pharyngobasilar Fascia
- Muscle - 3 constrictors, 3 other
- Buccopharyngeal Fascia (thickening of the epimysium of the muscle layer)
PHARYNX Attachments
Attachments of the Pharyngobasilar Fascia
- Pharyngeal tubercle (occipital bone) - Laterally across longus colli, anterior to carotid canal/foramen lacerum, drapes off ET - Medial Pterygoid plate down to hamulus
PHARYNX Constrictors
Constrictor muscles insert to the pharyngeal raphe (midline posteriorly) and fan out from there to the following attachments:
- Superior - Hamulus, pterygomandibular raphe, mandible
- Middle - Angle between Stylohyoid (at lesser horn) and hyoid bone
- Inferior - 2 parts: - Thyropharyngeus - Oblique line of thyroid and fibres spanning CT muscle - Cricopharyngeus - Cricoid cartilage (full ring of muscle) - Killian’s dehiscence between TP and CP
PHARYNX Structures entering & relationship to constrictors
Structures enter pharynx from outside:
Above SC - Eustachian tube
Between SC/MC - IX, Lingual N, Stylopharyngeus
Between MC/IC - IBSLN, SL vessels (thyrohyoid membrane)
Under IC - RLN
PHARYNX Innervation
Innervation - All pharyngeal plexus (IX, X, SNS fibres) - SNS fibres are vasoconstrictor - Arise in Nucleus Ambiguus - Except Stylopharyngeus - IX
TONSIL ANATOMY Def and parts
Paired lymphoid aggregates in the lateral oropharyngeal wall forming part of Waldeyer’s Ring
- Specialized lymphoid aggregates with external lining of stratified squamous epithelium
2 borders - Anterior - Palatoglossal arch - Posterior - Palatopharyngeal arch
2 poles - Upper - Soft palate - Lower - Tongue base
2 surfaces - Medial - Pharyngeal mucosa (stratified squamous epithelium) with crypts (up to 20 in number) - Lateral - Covered by capsule ( a thickening of the submucosa/extension of PB fascia) - Connective tissue septae extend to tonsil from capsule (not easily separated)
TONSIL ANATOMY Relations
Relations of the tonsil
- SC
- Stylopharyngeus, Styloglossus, Stylohyoid lig, Styloid process
- ICA (2cm posterolateral to tonsil bed)
- IX
TONSIL ANATOMY Blood sup
Blood supply:
5 arterial sources, tonsillar branches of
- Ascending pharyngeal a.
- Lesser palatine a. (3rd part IMA)
- Ascending palatine a. (branch of Facial a.)
- Facial a.
- Lingual a.
Venous drainage
- Venous plexus forms around capsule then drain to tonsil branch of Lingual v.
- Accessory Tonsil v. (drains to pharyngeal plexus)
- External palatine v. (superior pole)
TONSIL ANATOMY Embrology
Embryology:
Begins 12 weeks
Derived from 2nd pharyngeal pouch endoderm
Lymphocytes migrate into the area (mesoderm)
8-10 buds of pharyngeal squamous epithelium grow into the pharyngeal walls —> crypts formed
TONSIL ANATOMY Histo & epithelium
Embryology:
Begins 12 weeks
Derived from 2nd pharyngeal pouch endoderm
Lymphocytes migrate into the area (mesoderm)
8-10 buds of pharyngeal squamous epithelium grow into the pharyngeal walls —> crypts formed
TONSIL ANATOMY Zones
Zones:
- Specialised squamous epithelium (epithelium invaginates as the crypts- increase surface area to compensate for lack of afferents) - Lymphoepithelium = epithelium + lymphocytes + macrophages + dendritic cells (APC) - Captures foreign material from the epithelial surfaces
- Parafollicular (T-cell rich) - Dendritic cells present antigens on their cell surface via MHC-II molecules, interacting with CD4+ T cells (assisted by co-stimulatory molecules e.g. CD80)
- Mantle zone = lymphocytic cap around the germinal centre (B-cell predominant) - Primed T cells interact with naive B cells with co-stimulatory CD-40 —> B cell proliferation and differentiation - B cells migrate to the lymphoid follicle (forming germinal centres)
- Germinal centres (B-cell rich) - B cell proliferation, high affinity mutation, isotype switching and maturation - Produces Plasma cells and memory B cells
TONSIL ANATOMY Difference from lymph node
Differences from lymph nodes:
- Non-encapsulated
- No afferent lymphatic channels
Front-line defense at mucosal site
- Secretory Ig regulation
SOFT PALATE Innervation
Innervation
- All pharyngeal plexus (IX, X, SNS fibres)
- SNS fibres are vasoconstrictor
- Arise in Nucleus Ambiguus
- Except TVP - Nerve to Medial Pterygoid (V3)
Palatopharyngeal sphincter:
Level of hard palate (C1)
Forms Passavant’s ridge
SOFT PALATE Muscles
Made up of 5 paired muscles:
- Tensor Veli Palatini Arises outside pharynx - 2 triangles converge on the pterygoid hamulus - Vertical (muscular) - arises from scaphoid fossa (med pterygoid plate), lateral cartilagenous ET, spine of sphenoid - Horizontal (aponeurotic) - attaches to other side, hard palate. Posterior edge is free
- Levator Veli Palatini Arises inside pharynx - Arises from petrous apex (ant. to ICA) and medial cartilagenous ET - Inserts to nasal surface of aponeurosis (interdigitates with other side to form a V-shaped sling)
- Palatopharyngeus (Palatolaryngeus) post faucial pillar - Arises from 1. nasal surface of aponeurosis and 2. hard palate - Inserts to superior horn of thyroid cartilage and thyroid lamina
- Palatoglossus Ant faucial pillar - Arises from under surface of aponeurosis - Interdigitates with Styloglossus
- Musculus uvulae - unimportant
SOFT PALATE Histology
Histology: Oral surface = stratified squamous epithelium Nasal surface = respiratory epithelium
SOFT PALATE What form’s passavant’s ridge?
Palatopharyngeal sphincter:
Level of hard palate (C1)
Forms Passavant’s ridge
OESOPHAGUS Def Parts Relations in thorax
Cricoid cartilage to cardiac orifice of stomach (C6-T10), 25cm long
2 portions
Cervical - Slightly to L of midline, then enters thorax in midline
Thoracic - Slightly to L of midline against vertebral bodies, behind L main bronchus, passes in front of descending aorta (i.e. off vertebrae) in contact with pericardium (L atrium)
Relations in thorax
Crossed by aortic arch on left and azygos vein on right
Crossed anteriorly by L main bronchus and R pulmonary artery
Thoracic duct crosses behind oesophagus (R to L) L atrium
OESOPHAGUS Constrictions
Constrictions
15cm - Cricopharyngeus
22cm - Aortic arch
27cm - Left main bronchus
38cm - Diaphragm
OESOPHAGUS Structure
Structure
Epithelium- stratified squamous
Muscularis mucosae- thick
Submucosa- sparse mucous glands
Muscular wall- inner circular, outer longitudinal - Skeletal in upper 1/3, visceral in lower 2/3
No serosa (except the short intra-abdominal course)
OESOPHAGUS Blood supply
Arterial supply
Upper- Inferior thyroid artery
Middle- Oesophgeal branches of aorta
Lower- Oesophageal branches of L gastric artery Venous drainage
Upper - Brachiocephalic veins
Middle - Azygos veins
Lower - L gastric vein (to Portal vein)
OESOPHAGUS Nerve supply Lymph drainage
Nerve supply
Upper - RLN
Middle - Unnamed CN X branches
Lower - Oesophageal plexus (CN X branches Lymph Follows arteries
BRONCHIAL BRANCHING Overall structure Blood supply
Trachea — Mainstem Bronchi (Primary) — Lobar Bronchi (Secondary) — Segmental bronchi (Tertiary) — Bronchioles — Alveolar duct
Lobar bronchi:
- 3 on right
- 2 on left (upper includes lingula segmental bronchi)
Segmental bronchi: Each segmental bronchus enters a pyramid shaped bronchopulmonary segment with its apex pointing towards the hilum
Blood supply:
Artery - bronchial a. from aorta
Venous - Right —> Azygos, Left —> Hemiazygos
BRONCHIAL BRANCHING Left segmental brochi
Left side: ASIA ALPS (or ASIA SAMPL)
- Upper - Apical - Sup Lingula - Inf Lingula - Anterior
- Lower - Anterior - Lateral - Posterior - Superior