Anatomy

Question 1

What transporters are on RBCs?

Answer 1

Cl-/HCO3- antiporters

Question 2

Function of Cl-/HCO3- antiporters?

Answer 2

Export HCO3- and transport CO2 from tissues to lungs

Question 3

Varying sizes of RBCs

Answer 3

Anisocytosis

Question 4

Varying shapes of RBCs

Answer 4

Poikilocytosis

Question 5

Immature RBC

Answer 5

Reticulocyte

Question 6

Bluish color on Wright-Giemsa stain of reticulocyte

Answer 6

Residual ribosomal RNA

Question 7

What do dense granules of platelets contain?

Answer 7

ADP and calcium

Question 8

What do a-granules of platelets contain?

Answer 8

vWF, fibrinogen, and fibronectin

Question 9

Where is 1/3 of platelet pool stored?

Answer 9

Spleen

Question 10

vWF receptor

Answer 10

GpIb

Question 11

Fibrinogen receptor

Answer 11

GpIIb/IIIa

Question 12

Hypersegmented neutrophils are seen in what condition?

Answer 12

Vitamin B12 or folate deficiency

Question 13

Immature neutrophil

Answer 13

Band cell

Question 14

Increased band cells are seen in what conditions?

Answer 14

Infections or CML

Question 15

What do increased band cells reflect?

Answer 15

Myeloid proliferation

Question 16

What are neutrophil chemotactic agents?

Answer 16

C5a, IL-8, LTB4, kallikrein, platelet-activating factor

Question 17

Organelle within neutrophil that has azurophilic granules

Answer 17

Lysosome

Question 18

Activates macrophages

Answer 18

IFN-y

Question 19

Which MHC molecule is used by macrophages?

Answer 19

MHC-II

Question 20

Where are histiocytes found?

Answer 20

In connective tissue

Question 21

Where are Kupffer cells found?

Answer 21

In liver

Question 22

How do bacterial interact with macrophages to cause septic shock

Answer 22

Lipid a binds CD14 on macrophage

Question 23

Type of nucleus in eosinophil

Answer 23

Bilobate nucleus

Question 24

What are some causes of eosinophilia?

Answer 24

NAACP:
Neoplasia
Asthma
Allergic process
Chronic adrenal insufficiency
Parasites (invasive)

Question 25

What is basophilia an indication of?

Answer 25

Myeloproliferative disease like CML

Question 26

Cell types that mediate allergic reactions?

Answer 26

Basophils and Mast cells

Question 27

What is contained in granules of basophils

Answer 27

Histamine and heparin

Question 28

Cell type that originates from same precursor as basophils

Answer 28

Mast cell

Question 29

Cell type that can bind Fc portion of IgE to membrane causing IgE to cross-link and degranulation

Answer 29

Mast cell

Question 30

What hypersensitivity reaction is a mast cell involved in?

Answer 30

Type I

Question 31

Asthma prophylaxis used to prevent mast cell degranulation

Answer 31

Cromolyn sodium

Question 32

Highly phagocytic antigen presenting cell that functions as a link between innate and adaptive immune system

Answer 32

Dendritic cell

Question 33

What are dendritic cells called in the skin?

Answer 33

Langerhans cells

Question 34

What type of receptors are expressed on dendritic cells?

Answer 34

MHC-II and Fc receptors

Question 35

Cells that are round with densely stained nucleus and small amount of cytoplasm

Answer 35

Lymphocytes

Question 36

What are the different types of lymphocytes?

Answer 36

B-cells, T-cells, NK cells

Question 37

Which lymphocytes mediate the adaptive immune system?

Answer 37

B and T-cells

Question 38

Which lymphocyte is part of the innate immune system?

Answer 38

NK cells

Question 39

Lymphocyte that is part of the humoral immune response?

Answer 39

B cell

Question 40

What MHC class molecule is expressed on B cells?

Answer 40

MHC-II

Question 41

Where in the lymph node to B-cells migrate to?

Answer 41

Follicles

Question 42

Where in the spleen are B-cells located?

Answer 42

White pulp

Question 43

Unencapsulated lymphoid tissue has what type of lymphocytes?

Answer 43

B-cells

Question 44

Lymphocyte that mediates cellular immune response

Answer 44

T-cells

Question 45

What CD marker to helper T-cells express?

Answer 45

CD28

Question 46

What signal is needed for T-cell activation?

Answer 46

Costimulatory signal (B7 on APC binds CD28 on T cell)

Question 47

Which cells are the primary target of HIV?

Answer 47

CD4+ helper T-cells

Question 48

MHC molecule recognized by CD8+ T-cells

Answer 48

MHC-I

Question 49

MHC molecule recognized by CD4+ T-cells

Answer 49

MHC-II

Question 50

Where are plasma cells normally found?

Answer 50

In bone marrow

Question 51

What malignancy is a plasma cell cancer?

Answer 51

Multiple myeloma

Question 52

Type of cell with "clock-face" chromatin and eccentric nucleus, abundant RER, and well-developed Golgi apparatus

Answer 52

Plasma cell

Question 53

What receptors are found on CD4+ T-cells?

Answer 53

CD3 and CD4

Question 54

What receptors are found on CD8+ T-cells?

Answer 54

CD3 and CD8