Anatomy 2 Final Flashcards
how many liters of blood are in an adult?
4 to 6 liters
what is blood considered to be?
connective tissue
what are the components of blood?
erythrocytes, plasma, buffy coat
what are the formed elements of blood?
erythrocytes and buffy coat, these formed elements and liquid plasma compose whole blood
erythrocytes
red blood cells
- form the lower layer of centrifuged blood
- about 44% of the blood sample
buffy coat
the middle layer of centrifuged blood
- thin, slightly grey white layer composed of leukocytes (white blood cells) and cell fragments (platelets)
- 1% of blood sample
plasma
top layer of centrifuged blood
- straw colored liquid
- 55% of blood
functions of blood
- transportation (rbc carry oxygen from lungs to cells and CO2 from cells back to lungs; plasma transports nutrients from gi tract and hormones secreted by glands to target cells; plasma carries waste from cells to kidneys to be removed)
- regulation of body temp (plasma absorbs & distributes heat, vessels dilate to cool and constrict to conserve heat)
- maintenance of fluid levels (maintains fluid level in cardiovascular system)
- maintenance of pH levels (keeps pH at 7.4 for normal cell functioning)
- protection (wbc guard against infection, plasma transports antiobodies, platelets & proteins protect against blood loss by forming blood clots)
components of plasma
- extracellular fluid matrix of blood
- mixture of water, proteins and other solutes (enzymes, nutrients, wastes, hormones)
- 92 % water (facilitates transportation)
- w/o proteins call serum
- 7% proteins
albumins
smallest and most abundant plasma protein
- regulate water movement between blood and interstitial fluid
- transport proteins that carry ions, hormones and some liquids in blood
globulins
second largest group (37%)
alpha- smaller and primarily bind, support and protect water insoluble or hydrophobic molecules, hormones and ions
gamma- immunoglobulins, produced by defense cells to protect body against pathogens
fibrinogen
4% of plasma proteins, responsible for blood clot formation
regulatory proteins
very minor class of plasma protein, include enzymes to accelerate chemical reactions in blood and hormones transported to target cells
hematocrit
% of erythrocytes in the blood, vary upon age and gender
males 42%-56%
females 38%-46%
childrens also vary
also dependent upon altitude, body produces more rbc at higher altitudes because they carry the oxygen to cells
erythrocytes
mature rbc lack nuclei-allows to carry gasses more efficiently
transport oxygen and carbon dioxide to and from cells and lungs
hemoglobin
280 million molecules of red pigment hemoglobin per rbc
all have 4 protein building blocks
4 ions allow for 4 oxygen molecules to bind to each molecule
oxygen binding is weak (get from lungs and this allows them to easily detach in tissues where oxygen is needed)
life cycle of erythrocyte
no organells, so they can't sustain themselves life span 120 days daily: about 1% of oldest rbc's removed -phagocyted by sp and lv via macrophages some components saved some discarded
what components of old rbc cells are saved and why?
heme group- converted to biliverdin (green pigment), then to bilirubin in bile to help emulsify fat and then removed
iron- transferrin transports it to liver, turns to ferritin for storage and transported to red bone marrow
leukocytes
white blood cells, true cells with nuclei and organells
no hemoglobin.
5 types devided into 2 categories. granulocytes and agranulocytes
agranulocytes
lymphocytes
-tcell manage and direct immune response
-bcell stimulated to become plasma cells and produce antiobodies
-natural killer cells attack abnormal and infected tissue cells
monocytes
-phagocytize bacteria, cell fragments, dead cells, debris
endocrine system
works with the nervous system to maintain homeostasis
- endocrine glands produce hormones
- hormones are chemicals secreted into blood stream to stimulate a response from another tissue or organ
- target cells have the receptors for hormones
major endocrine organs
hypothalamus, pituitary gland, pineal gland, parathyroid glad, brain, heart, small intestines, adreanal gland, pancrease, kidney, thymus, thyroid gland, ovary, testis
difference between endocrine and exocrine glands
endocrine-no ducts, intracellular effects (metabolism), secrete directly to bloodstream, located in highly vascularized areas
exocrine- ducts, carry secretion to body surface or organ cavity extracellular affect (digetion)
classification of hormones
peptide (hydrophyllic-polar)- chains of amino acids ex. growth hormone
steroid (hydrophobic-nonpolar)- lipid derived from cholesterol ex. testosterone
biogenic amines (hydrophobic-nonpolar) small molecule produced by altering a structure of an amino acid ex. thyroid hormone
endocrine function of the heart
decrease blood volume and blood pressure and increase sodium and water loss by kidneys
endocrine function of kidneys
increase absorption of calcitrol and decrease its loss from bone deposition
erythropoietin- stimulates bonemarrow to produce rbc’s