Anatomy Flashcards
What do bones attach to?
Other bones (direct, indirect via tendon, fascia, ligament, cartilage), organs (eyes), mucous membranes (tongue), skin (fascia)
Major blood supply to UE vs LE
Subclavian arteries vs external iliac arteries
How are muscles divided in the limbs?
Compartmentalized by deep fascia; arteries w/in compartments give blood supply to nearby muscle
Anastomoses
Connections b/w vessels that provide collateral circ; more in veins and lymphatics, less in arteries (it’ll inc d/t demand or dz)
purposes of skeleton
support, protection, movement, storage, blood cell formation
muscle shapes: flat vs pennate vs fusiform vs convergent vs quadrate vs circular/sphincteral vs multiheaded/bellied
parallel fibers w/ aponeurosis vs featherlike, uni/multi vs spindle shaped w/ tapered ends vs from broad area and converge to single tendon vs 4 sides b/w attachments vs surrounds body opening, constricts when contracted vs >1 attachment or contractile belly
vein comitantes/accompanying veins
when veins surround artery –> artery pulsates –> surrounding veins do too –> improve blood/nutrient flow. veins nmlly don’t pulsate
varicose veins
veins lose elasticity –> weaken and dilate –> valves become incompetent –> incompetent fascia –> can’t ctx muscles
can blood flow reverse? hat happens if no anastomoses?
yes thru anastomoses. ischemia
3 fxns of lymphatics
immune, cardiovasc (bring fluid to heart), digestive
spinal nerves vs cranial nerves
31 pairs, exit spinal cord thru intervertebral foramina vs 12 pairs, exit CNS thru openings of cranium
plexus
where fibers from several spinal levels join and form branching network
radioopaque vs radiolucent
more dense structures –> bright vs less dense structures –> dark
angiography vs barium study
shows distribution of arteries vs ingest barium contrast to study GI tract
CT. advantages vs disadvantages?
compilations of spiral XR that make cross-sectional views of body; includes iodine contrast to identify vasc structures (don’t use iodine for bad kidney fxn). quicker, cheaper, more readily available –> best for trauma case vs can’t distinguish soft tissue like MRI, metal can interfere, less sensitive for brain imging
MRI. advantages vs disadvantages?
uses strong magnetic field and pulses body w/ radiowaves –> diff tissue produce diff signals produced by free H (water imging). no radiation, high res –> distinguish soft tissues, imgs can be reconstructed in any plane regardless of pt position vs strong magnetic field interferes w/ pacemakers, cochlear implants, surgical clips; don’t do if pt = claustrophobic
US. advantages vs disadvantages?
more common in ER for MSK dx and procedures; high freq waves reflect off diff structures. quick and safest vs not good for structures filled w/ gas, high res only for tissue close to skin, bone and dense structures cause shadowing
nuclear imging and examples
find trace amounts of radioactive substances in body. ex: PET scan finds gamma rays from ca cells; bone scan finds radiolabeled markers taken up by bone; SPECT imging uses single p+ emission + CT for better res
paraxial vs intermediate vs lateral mesoderm
become somite vs become urinary and reproductive system vs parietal/somatic –> muscles of body wall, bones of limbs OR visceral/splanchnic –> muscles of gut/GI tract
somites can become: sclerotome vs myotome vs dermatome
become vertebrae vs muscles of body wall/trunk, limbs, back; each myotome = innervated by one spinal nerve vs become dermis of body wall, back; represents area of skin innervated by one spinal nerve
neural crest vs neurons
differentiates into nerve cells innervating dermatome vs from neural tube innervating myotome
why and how does sclerotome split?
to allow passage of spinal nerves. caudal part of one sclerotome fuses w/ cranial part of next sclerotome
describe muscle formation
mesoderm and neural crest –> mesenchyme –> myoblasts –> mature muscle cells –> inc # of myofilaments for muscle growth (muscle cells don’t divide even tho they have SOME muscle stem cells)
skel vs cardiac vs smooth muscle
striated, voluntary; from myotomes in head and trunk, and from parietal lateral mesoderm vs unstriated, involuntary, visceral; from visceral lateral mesoderm surrounding heart tube –> heart vs unstriated, involuntary, visceral; from parietal lateral mesoderm –> sm muscle in blood vessel wall, from visceral lateral mesoderm surrounding gut tube –> sm muscle in gut, from ectoderm –> sm muscle in sweat and mammary glands
2 clusters of myotome: dorsomedial vs ventrolateral to dermatome
both contiguous but remain distinct. becomes epimere; epimere = innervated by dorsal ramus vs hypomere –> mixes w/ muscle fibers of parietal lateral mesoderm –> muscles of anterior body wall; hypomere = innervated by ventral ramus
epimere vs hypomere
from dorsomedial myotome cluster; innervated by dorsal ramus; become epaxial muscles (above transverse process –> TRUNK); form extensors of head, neck, back => erector spinae group vs from ventrolateral myotome cluster; innervated by ventral ramus; become hypaxial muscles (below transverse process –> LIMBS); form flexors of erector spinae group + intercostal, abd, serratus, quadratus, pelvic floor, limbs
Prune Belly Syndrome
from absent or poorly formed abd wall muscles –> fluid accumulate in abd –> distended abd –> wrinkly appearance –> urinary and reproductive malformations
describe eye muscle formation
not from somites; from preotic myotome in cranial paraxial mesoderm
describe face muscle formation
from cranial mesoderm derived mesenchyme (facial muscles) and neural crest derived mesenchyme (tendons and fascia of facial muscles) in pharyngeal arches; each arch has associated cranial nerve innervating the muscle from that arch
describe limb bud formation
appear on sides of embryo in cervical and sacral regions in 4/5th wk –> 1) myotome & dermatome mesenchyme migrate to limb buds –> myotome makes ant/post condensation –> muscles of limb; 2) parietal lateral mesoderm migrate to limb buds –> central core –> skel and vasc components of limbs
apical ectodermal ridge
leading edge of limb bud forming a ridge of epithelium (ectoderm); secretes growth factors –> development and differentiation of limb
describe upper limb formation
formed by day 26-27. lateral mesoderm migrate to limb bud in 4th wk and paraxial mesoderm/myotome migrate to limb bud in 5th wk –> ant condensation –> flexor and pronator muscles; post condensation –> extensor and supinator muscles; ventral rami of spinal nerves C5-T1 combine then divide to ant division –> innervate ant condensation; post division –> innervate post condensation. dermatome also migrates an creates segmented pattern on skin
describe lower limb formation
formed by day 30-31. lateral mesoderm and paraxial mesoderm/myotome migrate to limb bud –> ant condensation –> flexor and adductor muscles; post condensation –> extensor and abductor muscles; ventral rami of spinal nerves L2-S3 divide into ant division –> innervate ant condensation; post division –> innervate post condensation; dermatome also migrates and creates segmented pattern on skin
Describe hand and feet formation
Hand plates develop in upper limb buds in wk6, foot plates develop in lower limb buds in wk 7; digits rays form in hand/foot plates in wk 6/7 respectively
Describe nail formation
Nail beds form wk 11, nails form wk 12; nail growth = consistent —> can determine degree of prematurity
Describe epidermal friction ridge formation (fingerprints/footprints)
Form at jxn of epi/dermis in wk 11 —> ridges = pronounced in wk 16 —> “fingerprints”
Describe bone limb formation
Mesenchyme/central core —> primordial bones —> chondrification centers form in primordial bones in wk 6 —> IZ mesenchyme form b/w cartilage models —> ossification centers form in cartilage models in wk 7
What do HOX genes vs Tbox genes vs BMP do w/ limbs?
Create somite identity, limb differentiation along its length vs differentially expressed in UE & LE (determines location) vs for chondrification and ossification
Zone of polarizing activity (ZPA)
Secretes sonic hedgehog and retinoic acid —> differentiate limbs like radius/ulna, tibia/fibula, thumb (low conc)/pinky (high conc)
What’s the most critical period for limb development?
24-36d post fertilization
bone and muscle malformation: amelia vs meromelia vs talipes/club foot
Absence of limb; caused by genetic and environ factors (best known thalidomide) vs absence of part of limb, presence of limb stump; caused by genetic and environ factors (best known thalidomide) vs actually a deformation; foot fixed at abnml position, can occur independently or w/ syndrome
Muscle malformation: arthrogryposis
Absence of muscle, muscle hypoplasia —> stiffness and ctx across joints